No Cover Image

Journal article 103 views 12 downloads

In Silico Simulation of Porous Geometry-Guided Diffusion for Drug-Coated Tissue Engineering Scaffold Design

EYAD AWAD, Matt Bedding Orcid Logo, Alberto Coccarelli Orcid Logo, Feihu Zhao Orcid Logo

Organoids, Volume: 4, Issue: 2, Start page: 8

Swansea University Authors: EYAD AWAD, Matt Bedding Orcid Logo, Alberto Coccarelli Orcid Logo, Feihu Zhao Orcid Logo

  • organoids-04-00008.pdf

    PDF | Version of Record

    © 2025 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.

    Download (2.55MB)

Check full text

DOI (Published version): 10.3390/organoids4020008

Abstract

Recent research works have shown the effect of nutrient concentration on cell activity, such as proliferation and differentiation. In 3D cell culture, the impact of scaffold geometry, including pore size, strut diameter, and pore shape, on the concentration gradient within scaffolds under two differ...

Full description

Published in: Organoids
ISSN: 2674-1172
Published: MDPI AG 2025
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa69482
first_indexed 2025-05-09T12:19:28Z
last_indexed 2025-05-10T08:17:57Z
id cronfa69482
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2025-05-09T13:20:41.0913241</datestamp><bib-version>v2</bib-version><id>69482</id><entry>2025-05-09</entry><title>In Silico Simulation of Porous Geometry-Guided Diffusion for Drug-Coated Tissue Engineering Scaffold Design</title><swanseaauthors><author><sid>03f321f7bbad7a80e2d7f04b2a97255f</sid><firstname>EYAD</firstname><surname>AWAD</surname><name>EYAD AWAD</name><active>true</active><ethesisStudent>true</ethesisStudent></author><author><sid>d44c21114186f602f81db0dd1280b99d</sid><ORCID>0000-0003-0620-2773</ORCID><firstname>Matt</firstname><surname>Bedding</surname><name>Matt Bedding</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>06fd3332e5eb3cf4bb4e75a24f49149d</sid><ORCID>0000-0003-1511-9015</ORCID><firstname>Alberto</firstname><surname>Coccarelli</surname><name>Alberto Coccarelli</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>1c6e79b6edd08c88a8d17a241cd78630</sid><ORCID>0000-0003-0515-6808</ORCID><firstname>Feihu</firstname><surname>Zhao</surname><name>Feihu Zhao</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2025-05-09</date><abstract>Recent research works have shown the effect of nutrient concentration on cell activity, such as proliferation and differentiation. In 3D cell culture, the impact of scaffold geometry, including pore size, strut diameter, and pore shape, on the concentration gradient within scaffolds under two different loading conditions&#x2014;constant fluid perfusion and non-fluid perfusion&#x2014;in a perfusion bioreactor is investigated by developing an in silico model of scaffolds. In this study, both triply periodic minimal surface (TPMS) (with gyroid struts) and non-TPMS (with cubic and spherical pores) scaffolds were investigated. Two types of criteria are applied to the scaffolds: static and perfusion culture conditions. In a static environment, the scaffold in a perfusion bioreactor is loaded with a fluid velocity of 0 mm/s, whereas in a dynamic environment, perfusion flow with a velocity of 1 mm/s is applied. The results of in silico simulation indicate that the concentration gradient within the scaffold is significantly influenced by pore size, strut diameter, pore shape, and fluid flow, which in turn affects the diffusion rate during drug delivery.</abstract><type>Journal Article</type><journal>Organoids</journal><volume>4</volume><journalNumber>2</journalNumber><paginationStart>8</paginationStart><paginationEnd/><publisher>MDPI AG</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>2674-1172</issnElectronic><keywords>tissue engineering; drug-coated scaffold; diffusion&#x2013;convection simulation; perfusion bioreactor</keywords><publishedDay>27</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2025</publishedYear><publishedDate>2025-04-27</publishedDate><doi>10.3390/organoids4020008</doi><url/><notes>Communication</notes><college>COLLEGE NANME</college><CollegeCode>COLLEGE CODE</CollegeCode><institution>Swansea University</institution><apcterm>Other</apcterm><funders/><projectreference/><lastEdited>2025-05-09T13:20:41.0913241</lastEdited><Created>2025-05-09T11:29:33.4669100</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering</level></path><authors><author><firstname>EYAD</firstname><surname>AWAD</surname><order>1</order></author><author><firstname>Matt</firstname><surname>Bedding</surname><orcid>0000-0003-0620-2773</orcid><order>2</order></author><author><firstname>Alberto</firstname><surname>Coccarelli</surname><orcid>0000-0003-1511-9015</orcid><order>3</order></author><author><firstname>Feihu</firstname><surname>Zhao</surname><orcid>0000-0003-0515-6808</orcid><order>4</order></author></authors><documents><document><filename>69482__34219__2d32fd7f42bb4c019b28f57b5b40857c.pdf</filename><originalFilename>organoids-04-00008.pdf</originalFilename><uploaded>2025-05-09T11:29:33.4492527</uploaded><type>Output</type><contentLength>2674635</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>&#xA9; 2025 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>https://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2025-05-09T13:20:41.0913241 v2 69482 2025-05-09 In Silico Simulation of Porous Geometry-Guided Diffusion for Drug-Coated Tissue Engineering Scaffold Design 03f321f7bbad7a80e2d7f04b2a97255f EYAD AWAD EYAD AWAD true true d44c21114186f602f81db0dd1280b99d 0000-0003-0620-2773 Matt Bedding Matt Bedding true false 06fd3332e5eb3cf4bb4e75a24f49149d 0000-0003-1511-9015 Alberto Coccarelli Alberto Coccarelli true false 1c6e79b6edd08c88a8d17a241cd78630 0000-0003-0515-6808 Feihu Zhao Feihu Zhao true false 2025-05-09 Recent research works have shown the effect of nutrient concentration on cell activity, such as proliferation and differentiation. In 3D cell culture, the impact of scaffold geometry, including pore size, strut diameter, and pore shape, on the concentration gradient within scaffolds under two different loading conditions—constant fluid perfusion and non-fluid perfusion—in a perfusion bioreactor is investigated by developing an in silico model of scaffolds. In this study, both triply periodic minimal surface (TPMS) (with gyroid struts) and non-TPMS (with cubic and spherical pores) scaffolds were investigated. Two types of criteria are applied to the scaffolds: static and perfusion culture conditions. In a static environment, the scaffold in a perfusion bioreactor is loaded with a fluid velocity of 0 mm/s, whereas in a dynamic environment, perfusion flow with a velocity of 1 mm/s is applied. The results of in silico simulation indicate that the concentration gradient within the scaffold is significantly influenced by pore size, strut diameter, pore shape, and fluid flow, which in turn affects the diffusion rate during drug delivery. Journal Article Organoids 4 2 8 MDPI AG 2674-1172 tissue engineering; drug-coated scaffold; diffusion–convection simulation; perfusion bioreactor 27 4 2025 2025-04-27 10.3390/organoids4020008 Communication COLLEGE NANME COLLEGE CODE Swansea University Other 2025-05-09T13:20:41.0913241 2025-05-09T11:29:33.4669100 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering EYAD AWAD 1 Matt Bedding 0000-0003-0620-2773 2 Alberto Coccarelli 0000-0003-1511-9015 3 Feihu Zhao 0000-0003-0515-6808 4 69482__34219__2d32fd7f42bb4c019b28f57b5b40857c.pdf organoids-04-00008.pdf 2025-05-09T11:29:33.4492527 Output 2674635 application/pdf Version of Record true © 2025 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. true eng https://creativecommons.org/licenses/by/4.0/
title In Silico Simulation of Porous Geometry-Guided Diffusion for Drug-Coated Tissue Engineering Scaffold Design
spellingShingle In Silico Simulation of Porous Geometry-Guided Diffusion for Drug-Coated Tissue Engineering Scaffold Design
EYAD AWAD
Matt Bedding
Alberto Coccarelli
Feihu Zhao
title_short In Silico Simulation of Porous Geometry-Guided Diffusion for Drug-Coated Tissue Engineering Scaffold Design
title_full In Silico Simulation of Porous Geometry-Guided Diffusion for Drug-Coated Tissue Engineering Scaffold Design
title_fullStr In Silico Simulation of Porous Geometry-Guided Diffusion for Drug-Coated Tissue Engineering Scaffold Design
title_full_unstemmed In Silico Simulation of Porous Geometry-Guided Diffusion for Drug-Coated Tissue Engineering Scaffold Design
title_sort In Silico Simulation of Porous Geometry-Guided Diffusion for Drug-Coated Tissue Engineering Scaffold Design
author_id_str_mv 03f321f7bbad7a80e2d7f04b2a97255f
d44c21114186f602f81db0dd1280b99d
06fd3332e5eb3cf4bb4e75a24f49149d
1c6e79b6edd08c88a8d17a241cd78630
author_id_fullname_str_mv 03f321f7bbad7a80e2d7f04b2a97255f_***_EYAD AWAD
d44c21114186f602f81db0dd1280b99d_***_Matt Bedding
06fd3332e5eb3cf4bb4e75a24f49149d_***_Alberto Coccarelli
1c6e79b6edd08c88a8d17a241cd78630_***_Feihu Zhao
author EYAD AWAD
Matt Bedding
Alberto Coccarelli
Feihu Zhao
author2 EYAD AWAD
Matt Bedding
Alberto Coccarelli
Feihu Zhao
format Journal article
container_title Organoids
container_volume 4
container_issue 2
container_start_page 8
publishDate 2025
institution Swansea University
issn 2674-1172
doi_str_mv 10.3390/organoids4020008
publisher MDPI AG
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering
document_store_str 1
active_str 0
description Recent research works have shown the effect of nutrient concentration on cell activity, such as proliferation and differentiation. In 3D cell culture, the impact of scaffold geometry, including pore size, strut diameter, and pore shape, on the concentration gradient within scaffolds under two different loading conditions—constant fluid perfusion and non-fluid perfusion—in a perfusion bioreactor is investigated by developing an in silico model of scaffolds. In this study, both triply periodic minimal surface (TPMS) (with gyroid struts) and non-TPMS (with cubic and spherical pores) scaffolds were investigated. Two types of criteria are applied to the scaffolds: static and perfusion culture conditions. In a static environment, the scaffold in a perfusion bioreactor is loaded with a fluid velocity of 0 mm/s, whereas in a dynamic environment, perfusion flow with a velocity of 1 mm/s is applied. The results of in silico simulation indicate that the concentration gradient within the scaffold is significantly influenced by pore size, strut diameter, pore shape, and fluid flow, which in turn affects the diffusion rate during drug delivery.
published_date 2025-04-27T05:56:32Z
_version_ 1835241405510844416
score 11.063819

Similar Items