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The use of Oscillatory Positive Expiratory Pressure (OPEP) for airways clearance in chronic respiratory conditions / CARWYN BRIDGES

Swansea University Author: CARWYN BRIDGES

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DOI (Published version): 10.23889/SUthesis.69796

Abstract

This thesis consists of three intrinsically linked but distinct studies examining the role of airways clearance in chronic lung disease. Study 1: Analysis of UK data collected multicentre prospective cohort study (Bronch-UK) on airways clearance techniques used in routine hospital care 2015-2022 and...

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Published: Swansea, Wales, UK 2025
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
Supervisor: Lewis, Keir E.
URI: https://cronfa.swan.ac.uk/Record/cronfa69796
first_indexed 2025-06-23T14:09:46Z
last_indexed 2025-06-24T04:56:14Z
id cronfa69796
recordtype RisThesis
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spelling 2025-06-23T15:34:06.9083858 v2 69796 2025-06-23 The use of Oscillatory Positive Expiratory Pressure (OPEP) for airways clearance in chronic respiratory conditions 87001e649baa4c81a458e4aff92116c0 CARWYN BRIDGES CARWYN BRIDGES true false 2025-06-23 This thesis consists of three intrinsically linked but distinct studies examining the role of airways clearance in chronic lung disease. Study 1: Analysis of UK data collected multicentre prospective cohort study (Bronch-UK) on airways clearance techniques used in routine hospital care 2015-2022 and factors associated with airway’s clearance choice. Data from 1579 patients showed 70% routinely using airways clearance techniques, which is higher than previously reported. Active cycle of breathing technique (ACBT) (77%) and OPEP (38%) being the most common used techniques with 24% using both. No differences in demographics or clinical parameters between those prescribed ACBT versus OPEP. Disease severity was associated with increased use of airways clearance techniques. Study 2: expecToratIon of sPutum Techniques real wOrld data in coPd (TIPTOP): A pilot randomised control trial study comparing two airways clearance techniques, ACBT versus OPEP (Aerobika). Recruiting patients that were experiencing an acute exacerbation of chronic obstructive pulmonary disease (COPD) within 3 days from hospital wards or emergency clinics. 19 received OPEP 23 received ACBT, the study struggled to recruit to target and retain data. Although both groups improved significantly and clinically importantly from baseline (during exacerbation), we found no difference in the primary outcome of Leicester cough questionnaire at three months between groups. Study 3: Three online focus groups explored views on OPEP and what improvements could be made, especially remote monitoring. The 1st group consisted of respiratory physiotherapists working in the NHS with experience prescribing airways clearance techniques in the real word; the 2nd and 3rd focus group was 5 and 2 participants respectively with COPD or bronchiectasis. The main findings were that OPEP was well-tolerated by patients and is valued by healthcare professionals. Smart enabled monitoring of OPEP would be beneficial, depending on cost, data security and technical complexity. E-Thesis Swansea, Wales, UK Airways Clearance, Oscillatory Positive expiratory pressure, OPEP, Physiotherapy, Respiratory 12 6 2025 2025-06-12 10.23889/SUthesis.69796 ORCiD identifier: https://orcid.org/0000-0002-4181-1913 COLLEGE NANME COLLEGE CODE Swansea University Lewis, Keir E. Doctoral Ph.D Respiratory innovation Wales /TriTech Respiratory innovation Wales /TriTech 2025-06-23T15:34:06.9083858 2025-06-23T15:06:46.2621533 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science CARWYN BRIDGES 1 69796__34549__1eb3cb72a3d24b47bca863cef4afa936.pdf Bridges_Carwyn_G_PhD_Thesis_Final_Cronfa.pdf 2025-06-23T15:25:29.7560556 Output 7466280 application/pdf E-Thesis – open access true Copyright: The Author, Carwyn G. Bridges, 2025. true eng
title The use of Oscillatory Positive Expiratory Pressure (OPEP) for airways clearance in chronic respiratory conditions
spellingShingle The use of Oscillatory Positive Expiratory Pressure (OPEP) for airways clearance in chronic respiratory conditions
CARWYN BRIDGES
title_short The use of Oscillatory Positive Expiratory Pressure (OPEP) for airways clearance in chronic respiratory conditions
title_full The use of Oscillatory Positive Expiratory Pressure (OPEP) for airways clearance in chronic respiratory conditions
title_fullStr The use of Oscillatory Positive Expiratory Pressure (OPEP) for airways clearance in chronic respiratory conditions
title_full_unstemmed The use of Oscillatory Positive Expiratory Pressure (OPEP) for airways clearance in chronic respiratory conditions
title_sort The use of Oscillatory Positive Expiratory Pressure (OPEP) for airways clearance in chronic respiratory conditions
author_id_str_mv 87001e649baa4c81a458e4aff92116c0
author_id_fullname_str_mv 87001e649baa4c81a458e4aff92116c0_***_CARWYN BRIDGES
author CARWYN BRIDGES
author2 CARWYN BRIDGES
format E-Thesis
publishDate 2025
institution Swansea University
doi_str_mv 10.23889/SUthesis.69796
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
document_store_str 1
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description This thesis consists of three intrinsically linked but distinct studies examining the role of airways clearance in chronic lung disease. Study 1: Analysis of UK data collected multicentre prospective cohort study (Bronch-UK) on airways clearance techniques used in routine hospital care 2015-2022 and factors associated with airway’s clearance choice. Data from 1579 patients showed 70% routinely using airways clearance techniques, which is higher than previously reported. Active cycle of breathing technique (ACBT) (77%) and OPEP (38%) being the most common used techniques with 24% using both. No differences in demographics or clinical parameters between those prescribed ACBT versus OPEP. Disease severity was associated with increased use of airways clearance techniques. Study 2: expecToratIon of sPutum Techniques real wOrld data in coPd (TIPTOP): A pilot randomised control trial study comparing two airways clearance techniques, ACBT versus OPEP (Aerobika). Recruiting patients that were experiencing an acute exacerbation of chronic obstructive pulmonary disease (COPD) within 3 days from hospital wards or emergency clinics. 19 received OPEP 23 received ACBT, the study struggled to recruit to target and retain data. Although both groups improved significantly and clinically importantly from baseline (during exacerbation), we found no difference in the primary outcome of Leicester cough questionnaire at three months between groups. Study 3: Three online focus groups explored views on OPEP and what improvements could be made, especially remote monitoring. The 1st group consisted of respiratory physiotherapists working in the NHS with experience prescribing airways clearance techniques in the real word; the 2nd and 3rd focus group was 5 and 2 participants respectively with COPD or bronchiectasis. The main findings were that OPEP was well-tolerated by patients and is valued by healthcare professionals. Smart enabled monitoring of OPEP would be beneficial, depending on cost, data security and technical complexity.
published_date 2025-06-12T07:43:44Z
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score 11.08895

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