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Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives

Jie Zhong Orcid Logo, Juan Mareque-Rivas Orcid Logo, Xinmiao Lan Orcid Logo, Yu‐Xiong Su Orcid Logo

Aggregate, Start page: e70081

Swansea University Author: Juan Mareque-Rivas Orcid Logo

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DOI (Published version): 10.1002/agt2.70081

Abstract

Triterpenoids exhibit remarkable pharmacological characteristics and have garnered significant research attention, owing to their unique backbone structures and numerous modification sites. Recent advancements in supramolecular chemistry have highlighted the potential of triterpenoids to form organi...

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Published in: Aggregate
ISSN: 2692-4560 2692-4560
Published: Wiley 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa69830
Abstract: Triterpenoids exhibit remarkable pharmacological characteristics and have garnered significant research attention, owing to their unique backbone structures and numerous modification sites. Recent advancements in supramolecular chemistry have highlighted the potential of triterpenoids to form organized assemblies through noncovalent interactions, affording versatile functional properties. By leveraging their unique structural characteristics and biological activities, innovative strategies can be developed to enhance the efficacy and safety of biomedical therapies. This review describes the recent advances in triterpenoids serving as (i) functional groups for aggregation‐induced emission, (ii) building blocks for self‐transportation and drug delivery, (iii) potential gelators for rational hydrogel design, and (iv) cholesterol alternatives for optimizing lipid‐based nanoparticles. The biomedical perspectives of triterpenoid‐based supramolecular assemblies and potential bottlenecks in clinical translation are also discussed, with the hope of offering insights into future research and biomedical applications.
Item Description: Review
Keywords: hydrogels, nanotheranostics, natural products, supramolecular assembly, triterpenoids
College: Faculty of Science and Engineering
Funders: This study was supported by the National Natural Science Foundation of China (NSFC) project (32301133), the University of Hong Kong Seed Fund for Basic Research (104006533), and the R&D Program of Beijing Municipal Education Commission (KM202310025022).
Start Page: e70081

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