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Deconditioning in quiescent Crohn’s disease patients with heightened fatigue perception

Jordan J McGing Orcid Logo, Sébastien Serres, Rosemary Nicholas, Ayushman Gupta, Shellie J Radford, Aline V Nixon, Joanne Mallinson, Christopher Bradley, Stephen Bawden, Susan T Francis, Paul L Greenhaff, Gordon W Moran

Journal of Crohn's and Colitis, Volume: 19, Issue: 1

Swansea University Author: Stephen Bawden

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DOI (Published version): 10.1093/ecco-jcc/jjae194

Abstract

Background and ObjectiveInflammatory bowel disease (IBD) fatigue aetiology is poorly understood. This study quantified body composition and physical function alongside proton magnetic resonance imaging (1H MRI) and spectroscopy (31P MRS) measures of organ structure and function in quiescent Crohn’s...

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Published in: Journal of Crohn's and Colitis
ISSN: 1873-9946 1876-4479
Published: Oxford University Press (OUP) 2025
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URI: https://cronfa.swan.ac.uk/Record/cronfa70207
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This study quantified body composition and physical function alongside proton magnetic resonance imaging (1H MRI) and spectroscopy (31P MRS) measures of organ structure and function in quiescent Crohn&#x2019;s disease patients (CD) and healthy volunteers (HVs), to identify a physiological basis for IBD fatigue.MethodsBody composition was determined using dual-energy X-ray absorptiometry and 1H MRI. Knee extensor isometric strength and isokinetic fatigue were measured using dynamometry. 1H MRI was used to quantify cardiac output, cerebral blood flow (gmCBF), and brain oxygen extraction fraction (OEF) at rest, and during supine, steady-state exercise, and recovery. 31P MRS was used to quantify post-exercise muscle phosphocreatine (PCr) resynthesis.ResultsSixteen CD and 12 HV (age, sex, and BMI matched) were recruited. Fatigue perception was greater (13.9&#x2005;&#xB1;&#x2005;1 vs 8.3&#x2005;&#xB1;&#x2005;0.9, P&#x2005;=&#x2005;.001), and daily step count was less (5482&#x2005;&#xB1;&#x2005;684 vs 8168&#x2005;&#xB1;&#x2005;1123, P&#x2005;=&#x2005;.04) in CD. During steady-state exercise, gmCBF was less in CD (653&#x2005;&#xB1;&#x2005;30 vs 823&#x2005;&#xB1;&#x2005;40 mL/min, P&#x2005;=&#x2005;.003). Cardiac output and brain OEF were no different. Post-exercise PCr resynthesis was less in CD (17.2&#x2005;&#xB1;&#x2005;2.0 vs 25.3&#x2005;&#xB1;&#x2005;2.4 mM&#xB7;min&#x2212;1, P&#x2005;=&#x2005;.02). Body composition, isometric strength, and isokinetic fatigability were no different.ConclusionsCD self-reported increased fatigue perception and exhibited a slower rate of post-exercise PCr resynthesis compared to HV. This occurred independently of changes in body composition, muscle strength, and fatigability. 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spelling 2025-09-24T15:26:37.7631851 v2 70207 2025-08-21 Deconditioning in quiescent Crohn’s disease patients with heightened fatigue perception 592eebfd572257940e8ed8b2bf94be72 Stephen Bawden Stephen Bawden true false 2025-08-21 Background and ObjectiveInflammatory bowel disease (IBD) fatigue aetiology is poorly understood. This study quantified body composition and physical function alongside proton magnetic resonance imaging (1H MRI) and spectroscopy (31P MRS) measures of organ structure and function in quiescent Crohn’s disease patients (CD) and healthy volunteers (HVs), to identify a physiological basis for IBD fatigue.MethodsBody composition was determined using dual-energy X-ray absorptiometry and 1H MRI. Knee extensor isometric strength and isokinetic fatigue were measured using dynamometry. 1H MRI was used to quantify cardiac output, cerebral blood flow (gmCBF), and brain oxygen extraction fraction (OEF) at rest, and during supine, steady-state exercise, and recovery. 31P MRS was used to quantify post-exercise muscle phosphocreatine (PCr) resynthesis.ResultsSixteen CD and 12 HV (age, sex, and BMI matched) were recruited. Fatigue perception was greater (13.9 ± 1 vs 8.3 ± 0.9, P = .001), and daily step count was less (5482 ± 684 vs 8168 ± 1123, P = .04) in CD. During steady-state exercise, gmCBF was less in CD (653 ± 30 vs 823 ± 40 mL/min, P = .003). Cardiac output and brain OEF were no different. Post-exercise PCr resynthesis was less in CD (17.2 ± 2.0 vs 25.3 ± 2.4 mM·min−1, P = .02). Body composition, isometric strength, and isokinetic fatigability were no different.ConclusionsCD self-reported increased fatigue perception and exhibited a slower rate of post-exercise PCr resynthesis compared to HV. This occurred independently of changes in body composition, muscle strength, and fatigability. IBD fatigue may be linked to peripheral muscle deconditioning and lower gmCBF during submaximal exercise. Journal Article Journal of Crohn's and Colitis 19 1 Oxford University Press (OUP) 1873-9946 1876-4479 9 1 2025 2025-01-09 10.1093/ecco-jcc/jjae194 COLLEGE NANME COLLEGE CODE Swansea University Another institution paid the OA fee This work was supported by the Crohn’s and Colitis UK Medical Research Award (M2017/6 to G.W.M) and by the Joan Browne Legacy at the University of Nottingham (PhD scholarship to J.J.M). 2025-09-24T15:26:37.7631851 2025-08-21T09:27:23.7615215 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Jordan J McGing 0000-0002-1238-0472 1 Sébastien Serres 2 Rosemary Nicholas 3 Ayushman Gupta 4 Shellie J Radford 5 Aline V Nixon 6 Joanne Mallinson 7 Christopher Bradley 8 Stephen Bawden 9 Susan T Francis 10 Paul L Greenhaff 11 Gordon W Moran 12 70207__35169__21bc9d67436f45b3af2d2521596b8f85.pdf 70207.VoR.pdf 2025-09-24T15:22:02.3783223 Output 1069645 application/pdf Version of Record true © The Author(s) 2025. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. true eng https://creativecommons.org/licenses/by/4.0/
title Deconditioning in quiescent Crohn’s disease patients with heightened fatigue perception
spellingShingle Deconditioning in quiescent Crohn’s disease patients with heightened fatigue perception
Stephen Bawden
title_short Deconditioning in quiescent Crohn’s disease patients with heightened fatigue perception
title_full Deconditioning in quiescent Crohn’s disease patients with heightened fatigue perception
title_fullStr Deconditioning in quiescent Crohn’s disease patients with heightened fatigue perception
title_full_unstemmed Deconditioning in quiescent Crohn’s disease patients with heightened fatigue perception
title_sort Deconditioning in quiescent Crohn’s disease patients with heightened fatigue perception
author_id_str_mv 592eebfd572257940e8ed8b2bf94be72
author_id_fullname_str_mv 592eebfd572257940e8ed8b2bf94be72_***_Stephen Bawden
author Stephen Bawden
author2 Jordan J McGing
Sébastien Serres
Rosemary Nicholas
Ayushman Gupta
Shellie J Radford
Aline V Nixon
Joanne Mallinson
Christopher Bradley
Stephen Bawden
Susan T Francis
Paul L Greenhaff
Gordon W Moran
format Journal article
container_title Journal of Crohn's and Colitis
container_volume 19
container_issue 1
publishDate 2025
institution Swansea University
issn 1873-9946
1876-4479
doi_str_mv 10.1093/ecco-jcc/jjae194
publisher Oxford University Press (OUP)
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
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description Background and ObjectiveInflammatory bowel disease (IBD) fatigue aetiology is poorly understood. This study quantified body composition and physical function alongside proton magnetic resonance imaging (1H MRI) and spectroscopy (31P MRS) measures of organ structure and function in quiescent Crohn’s disease patients (CD) and healthy volunteers (HVs), to identify a physiological basis for IBD fatigue.MethodsBody composition was determined using dual-energy X-ray absorptiometry and 1H MRI. Knee extensor isometric strength and isokinetic fatigue were measured using dynamometry. 1H MRI was used to quantify cardiac output, cerebral blood flow (gmCBF), and brain oxygen extraction fraction (OEF) at rest, and during supine, steady-state exercise, and recovery. 31P MRS was used to quantify post-exercise muscle phosphocreatine (PCr) resynthesis.ResultsSixteen CD and 12 HV (age, sex, and BMI matched) were recruited. Fatigue perception was greater (13.9 ± 1 vs 8.3 ± 0.9, P = .001), and daily step count was less (5482 ± 684 vs 8168 ± 1123, P = .04) in CD. During steady-state exercise, gmCBF was less in CD (653 ± 30 vs 823 ± 40 mL/min, P = .003). Cardiac output and brain OEF were no different. Post-exercise PCr resynthesis was less in CD (17.2 ± 2.0 vs 25.3 ± 2.4 mM·min−1, P = .02). Body composition, isometric strength, and isokinetic fatigability were no different.ConclusionsCD self-reported increased fatigue perception and exhibited a slower rate of post-exercise PCr resynthesis compared to HV. This occurred independently of changes in body composition, muscle strength, and fatigability. IBD fatigue may be linked to peripheral muscle deconditioning and lower gmCBF during submaximal exercise.
published_date 2025-01-09T05:30:15Z
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