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Heavy Metal Resistance Genes Are Associated with blaNDM-1- and blaCTX-M-15-Carrying Enterobacteriaceae

Qiu E. Yang, Siham Rajab Agouri, Jon Tyrrell Orcid Logo, Timothy Rutland Walsh

Antimicrobial Agents and Chemotherapy, Volume: 62, Issue: 5

Swansea University Author: Jon Tyrrell Orcid Logo

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DOI (Published version): 10.1128/aac.02642-17

Abstract

The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing blaNDM-1 or blaCTX-M-15 genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes o...

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Published in: Antimicrobial Agents and Chemotherapy
ISSN: 0066-4804 1098-6596
Published: American Society for Microbiology 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa70425
first_indexed 2025-09-21T22:01:41Z
last_indexed 2025-10-17T09:30:55Z
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spelling 2025-10-16T17:04:56.6780607 v2 70425 2025-09-21 Heavy Metal Resistance Genes Are Associated with blaNDM-1- and blaCTX-M-15-Carrying Enterobacteriaceae ad510c73555adf718387af219e235a6e 0000-0001-8565-2590 Jon Tyrrell Jon Tyrrell true false 2025-09-21 MEDS The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing blaNDM-1 or blaCTX-M-15 genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes occurred with higher frequencies in blaNDM-1-positive (48.8% to 71.8%) and blaCTX-M-15-positive (19.4% to 52.8%) isolates, and they were mostly located on plasmids. Given the high association of metal resistance genes with multidrug-resistant Enterobacteriaceae, increased vigilance needs to be taken with the use of heavy metals in hospitals and the environment. Journal Article Antimicrobial Agents and Chemotherapy 62 5 American Society for Microbiology 0066-4804 1098-6596 heavy metal resistance, blaNDM-1 , blaCTX-M-15 , plasmids, coresistance 1 5 2018 2018-05-01 10.1128/aac.02642-17 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University Another institution paid the OA fee Q.E.Y. was funded by a CSC scholarship, and T.R.W. was funded by HEFC. T.R.W. and Q.E.Y. were also supported by MRC grant DETER-XDR-China (MR/P007295/1). 2025-10-16T17:04:56.6780607 2025-09-21T18:12:56.0970718 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Qiu E. Yang 1 Siham Rajab Agouri 2 Jon Tyrrell 0000-0001-8565-2590 3 Timothy Rutland Walsh 4 70425__35375__6d4962821dcf49fc84b878b84e43a06f.pdf 70425.VoR.pdf 2025-10-16T17:02:08.9132480 Output 616067 application/pdf Version of Record true Copyright © 2018 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International license. true eng https://creativecommons.org/licenses/by/4.0/
title Heavy Metal Resistance Genes Are Associated with blaNDM-1- and blaCTX-M-15-Carrying Enterobacteriaceae
spellingShingle Heavy Metal Resistance Genes Are Associated with blaNDM-1- and blaCTX-M-15-Carrying Enterobacteriaceae
Jon Tyrrell
title_short Heavy Metal Resistance Genes Are Associated with blaNDM-1- and blaCTX-M-15-Carrying Enterobacteriaceae
title_full Heavy Metal Resistance Genes Are Associated with blaNDM-1- and blaCTX-M-15-Carrying Enterobacteriaceae
title_fullStr Heavy Metal Resistance Genes Are Associated with blaNDM-1- and blaCTX-M-15-Carrying Enterobacteriaceae
title_full_unstemmed Heavy Metal Resistance Genes Are Associated with blaNDM-1- and blaCTX-M-15-Carrying Enterobacteriaceae
title_sort Heavy Metal Resistance Genes Are Associated with blaNDM-1- and blaCTX-M-15-Carrying Enterobacteriaceae
author_id_str_mv ad510c73555adf718387af219e235a6e
author_id_fullname_str_mv ad510c73555adf718387af219e235a6e_***_Jon Tyrrell
author Jon Tyrrell
author2 Qiu E. Yang
Siham Rajab Agouri
Jon Tyrrell
Timothy Rutland Walsh
format Journal article
container_title Antimicrobial Agents and Chemotherapy
container_volume 62
container_issue 5
publishDate 2018
institution Swansea University
issn 0066-4804
1098-6596
doi_str_mv 10.1128/aac.02642-17
publisher American Society for Microbiology
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
document_store_str 1
active_str 0
description The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing blaNDM-1 or blaCTX-M-15 genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes occurred with higher frequencies in blaNDM-1-positive (48.8% to 71.8%) and blaCTX-M-15-positive (19.4% to 52.8%) isolates, and they were mostly located on plasmids. Given the high association of metal resistance genes with multidrug-resistant Enterobacteriaceae, increased vigilance needs to be taken with the use of heavy metals in hospitals and the environment.
published_date 2018-05-01T05:26:06Z
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score 11.089572

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