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E-Thesis 552 views 115 downloads

Clinically Actionable Biomarker Identification in Solid Tumour Diagnostic Cellular Pathology / ALISON FINALL

Swansea University Author: ALISON FINALL

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DOI (Published version): 10.23889/SUThesis.71426

Abstract

The landscape of tumour testing for genomic alterations is developing at an exceptionally fast pace and applies to all solid tumours now that tumour agnostic testing is required in patients who have failed standard oncology treatments with evidence of clinical and radiological progression (1-5) .The...

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Published: Swansea University
Institution: Swansea University
Degree level: Doctoral
Degree name: M.D
Supervisor: Morgan, C.
URI: https://cronfa.swan.ac.uk/Record/cronfa71426
Abstract: The landscape of tumour testing for genomic alterations is developing at an exceptionally fast pace and applies to all solid tumours now that tumour agnostic testing is required in patients who have failed standard oncology treatments with evidence of clinical and radiological progression (1-5) .The focus of the collection of the published works for presentation in this thesis examines how we might do things differently within histopathology laboratories to improve patient experiences, efficiency of workflows and clinical pathways for patients with non-squamous, non-small cell lung carcinoma (NSCLC) and metastatic malignant melanoma.The following papers form the submission for a Medical Doctorate degree. The research and literature reviews investigate, evidence and improve biomarker identification commenced following discovery of rapid, near patient, fully automated technology at the Royal Brompton Hospital, Thoracic Pathology Update Course in London May 2016
Keywords: Biomarkers, solid tumour, somatic gene testing
College: Faculty of Medicine, Health and Life Sciences

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