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Meta-Analysis of Short-Term Outcomes After Robotic Pancreaticoduodenectomy in Octogenarians

Ahmed Hassan, Martyn Charles Stott, Sarthak Jain Orcid Logo, Vasileios Kotsarinis, Hadiyat A. Ogunlayi, Lydia Loutzidou, Dimitrios Vouros, Amr Ebrahim, Shahin Hajibandeh Orcid Logo, SHAHAB HAJIBANDEH, Jacob Kadamapuzha, Thomas Satyadas

Geriatrics, Volume: 11, Issue: 1, Pages: 19 - 19

Swansea University Author: SHAHAB HAJIBANDEH

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DOI (Published version): 10.3390/geriatrics11010019

Abstract

Background/Objectives: To evaluate short-term postoperative outcomes in octogenarians undergoing robotic pancreaticoduodenectomy. Methods: In compliance with the PRISMA statement standards, a systematic review and random-effects meta-analysis was conducted. All studies reporting short-term postopera...

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Published in: Geriatrics
ISSN: 2308-3417
Published: MDPI AG 2026
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URI: https://cronfa.swan.ac.uk/Record/cronfa71484
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Results: A total of 321 octogenarians from five studies were included. The mean operative time was 459.7 min (95% CI 398.6&#x2013;520.8) and the estimated intraoperative blood loss was 216.1 mL (95% CI 147.4&#x2013;284.8). Conversion to open occurred in 3.8% (95% CI 0.0&#x2013;7.7). The risk of postoperative mortality was 4.5% (95% CI 1.7&#x2013;7.2) and Clavien-Dindo grade &#x2265; III (major) complications occurred in 28.0% (95% CI 22.9&#x2013;33.1). The risk of grade B or C postoperative pancreatic fistula was 10% (95% CI 6.5&#x2013;13.5). The hospital stay was 14.9 days (95% CI 10.2&#x2013;19.5). The risk of reoperation and readmission were 8.0% (95% CI 4.4&#x2013;11.7) and 25.6% (95% CI 16.9&#x2013;34.3), respectively. Compared to patients aged &lt;80, the risk of major complications was higher (OR: 1.81, p = 0.010) and hospital stay was longer (MD: 5.19 days, p = 0.030) in octogenarians. Compared to the open approach, robotic approach was associated with longer operative time (MD: 137.08 min, p = 0.0009), less intraoperative blood loss (MD: &#x2212;246.00 mL, p = 0.010), and lower major complications (OR: 0.62, p = 0.020). Conclusions: Subject to selection and confounding bias, robotic pancreaticoduodenectomy may be safe with acceptable postoperative mortality and morbidity in highly selected octogenarians with good performance status. 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spelling 2026-02-23T14:54:53.3423562 v2 71484 2026-02-23 Meta-Analysis of Short-Term Outcomes After Robotic Pancreaticoduodenectomy in Octogenarians b95fa4fe8ce5515ba689c728410200bd SHAHAB HAJIBANDEH SHAHAB HAJIBANDEH true false 2026-02-23 Background/Objectives: To evaluate short-term postoperative outcomes in octogenarians undergoing robotic pancreaticoduodenectomy. Methods: In compliance with the PRISMA statement standards, a systematic review and random-effects meta-analysis was conducted. All studies reporting short-term postoperative outcomes in patients aged ≥ 80 undergoing robotic pancreaticoduodenectomy were included and analyzed. Results: A total of 321 octogenarians from five studies were included. The mean operative time was 459.7 min (95% CI 398.6–520.8) and the estimated intraoperative blood loss was 216.1 mL (95% CI 147.4–284.8). Conversion to open occurred in 3.8% (95% CI 0.0–7.7). The risk of postoperative mortality was 4.5% (95% CI 1.7–7.2) and Clavien-Dindo grade ≥ III (major) complications occurred in 28.0% (95% CI 22.9–33.1). The risk of grade B or C postoperative pancreatic fistula was 10% (95% CI 6.5–13.5). The hospital stay was 14.9 days (95% CI 10.2–19.5). The risk of reoperation and readmission were 8.0% (95% CI 4.4–11.7) and 25.6% (95% CI 16.9–34.3), respectively. Compared to patients aged <80, the risk of major complications was higher (OR: 1.81, p = 0.010) and hospital stay was longer (MD: 5.19 days, p = 0.030) in octogenarians. Compared to the open approach, robotic approach was associated with longer operative time (MD: 137.08 min, p = 0.0009), less intraoperative blood loss (MD: −246.00 mL, p = 0.010), and lower major complications (OR: 0.62, p = 0.020). Conclusions: Subject to selection and confounding bias, robotic pancreaticoduodenectomy may be safe with acceptable postoperative mortality and morbidity in highly selected octogenarians with good performance status. The results of the current study can be used for hypothesis synthesis and power analysis in future comparative studies. Journal Article Geriatrics 11 1 19 19 MDPI AG 2308-3417 robotic; pancreaticoduodenectomy; octogenarian 13 2 2026 2026-02-13 10.3390/geriatrics11010019 Systematic Review COLLEGE NANME COLLEGE CODE Swansea University Another institution paid the OA fee This research received no external funding. 2026-02-23T14:54:53.3423562 2026-02-23T14:46:12.5484167 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Biomedical Science Ahmed Hassan 1 Martyn Charles Stott 2 Sarthak Jain 0009-0006-1289-0348 3 Vasileios Kotsarinis 4 Hadiyat A. Ogunlayi 5 Lydia Loutzidou 6 Dimitrios Vouros 7 Amr Ebrahim 8 Shahin Hajibandeh 0000-0001-6159-1068 9 SHAHAB HAJIBANDEH 10 Jacob Kadamapuzha 11 Thomas Satyadas 12 71484__36284__bbd3523efce94faf99b3a2f2f037fbeb.pdf 71484.VoR.pdf 2026-02-23T14:52:31.8965509 Output 3970135 application/pdf Version of Record true © 2026 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. true Eng https://creativecommons.org/licenses/by/4.0/
title Meta-Analysis of Short-Term Outcomes After Robotic Pancreaticoduodenectomy in Octogenarians
spellingShingle Meta-Analysis of Short-Term Outcomes After Robotic Pancreaticoduodenectomy in Octogenarians
SHAHAB HAJIBANDEH
title_short Meta-Analysis of Short-Term Outcomes After Robotic Pancreaticoduodenectomy in Octogenarians
title_full Meta-Analysis of Short-Term Outcomes After Robotic Pancreaticoduodenectomy in Octogenarians
title_fullStr Meta-Analysis of Short-Term Outcomes After Robotic Pancreaticoduodenectomy in Octogenarians
title_full_unstemmed Meta-Analysis of Short-Term Outcomes After Robotic Pancreaticoduodenectomy in Octogenarians
title_sort Meta-Analysis of Short-Term Outcomes After Robotic Pancreaticoduodenectomy in Octogenarians
author_id_str_mv b95fa4fe8ce5515ba689c728410200bd
author_id_fullname_str_mv b95fa4fe8ce5515ba689c728410200bd_***_SHAHAB HAJIBANDEH
author SHAHAB HAJIBANDEH
author2 Ahmed Hassan
Martyn Charles Stott
Sarthak Jain
Vasileios Kotsarinis
Hadiyat A. Ogunlayi
Lydia Loutzidou
Dimitrios Vouros
Amr Ebrahim
Shahin Hajibandeh
SHAHAB HAJIBANDEH
Jacob Kadamapuzha
Thomas Satyadas
format Journal article
container_title Geriatrics
container_volume 11
container_issue 1
container_start_page 19
publishDate 2026
institution Swansea University
issn 2308-3417
doi_str_mv 10.3390/geriatrics11010019
publisher MDPI AG
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Biomedical Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Biomedical Science
document_store_str 1
active_str 0
description Background/Objectives: To evaluate short-term postoperative outcomes in octogenarians undergoing robotic pancreaticoduodenectomy. Methods: In compliance with the PRISMA statement standards, a systematic review and random-effects meta-analysis was conducted. All studies reporting short-term postoperative outcomes in patients aged ≥ 80 undergoing robotic pancreaticoduodenectomy were included and analyzed. Results: A total of 321 octogenarians from five studies were included. The mean operative time was 459.7 min (95% CI 398.6–520.8) and the estimated intraoperative blood loss was 216.1 mL (95% CI 147.4–284.8). Conversion to open occurred in 3.8% (95% CI 0.0–7.7). The risk of postoperative mortality was 4.5% (95% CI 1.7–7.2) and Clavien-Dindo grade ≥ III (major) complications occurred in 28.0% (95% CI 22.9–33.1). The risk of grade B or C postoperative pancreatic fistula was 10% (95% CI 6.5–13.5). The hospital stay was 14.9 days (95% CI 10.2–19.5). The risk of reoperation and readmission were 8.0% (95% CI 4.4–11.7) and 25.6% (95% CI 16.9–34.3), respectively. Compared to patients aged <80, the risk of major complications was higher (OR: 1.81, p = 0.010) and hospital stay was longer (MD: 5.19 days, p = 0.030) in octogenarians. Compared to the open approach, robotic approach was associated with longer operative time (MD: 137.08 min, p = 0.0009), less intraoperative blood loss (MD: −246.00 mL, p = 0.010), and lower major complications (OR: 0.62, p = 0.020). Conclusions: Subject to selection and confounding bias, robotic pancreaticoduodenectomy may be safe with acceptable postoperative mortality and morbidity in highly selected octogenarians with good performance status. The results of the current study can be used for hypothesis synthesis and power analysis in future comparative studies.
published_date 2026-02-13T05:32:49Z
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