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Neuronal Activity in the Human Subthalamic Nucleus Encodes Decision Conflict during Action Selection / K. A Zaghloul; C. T Weidemann; B. C Lega; J. L Jaggi; G. H Baltuch; M. J Kahana

Journal of Neuroscience, Volume: 32, Issue: 7, Pages: 2453 - 2460

Swansea University Author: Weidemann, Christoph

Abstract

The subthalamic nucleus (STN), which receives excitatory inputs from the cortex and has direct connections with the inhibitory pathways of the basal ganglia, is well positioned to efficiently mediate action selection. Here, we use microelectrode recordings captured during deep brain stimulation surg...

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Published in: Journal of Neuroscience
ISSN: 0270-6474 1529-2401
Published: 2012
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa8382
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Abstract: The subthalamic nucleus (STN), which receives excitatory inputs from the cortex and has direct connections with the inhibitory pathways of the basal ganglia, is well positioned to efficiently mediate action selection. Here, we use microelectrode recordings captured during deep brain stimulation surgery as participants engage in a decision task to examine the role of the human STN in action selection. We demonstrate that spiking activity in the STN increases when participants engage in a decision and that the level of spiking activity increases with the degree of decision conflict. These data implicate the STN as an important mediator of action selection during decision processes.
College: College of Human and Health Sciences
Issue: 7
Start Page: 2453
End Page: 2460