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The incidence of unpleasant dreams after sub-anaesthetic ketamine

Mark Blagrove Orcid Logo, Celia J. A Morgan, H. Valerie Curran, Leslie Bromley, Brigitte Brandner

Psychopharmacology, Volume: 203, Issue: 1, Pages: 109 - 120

Swansea University Author: Mark Blagrove Orcid Logo

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DOI (Published version): 10.1007/s00213-008-1377-3

Abstract

Ketamine is an N-methyl-D-aspartate (NMDA)receptor antagonist with psychotogenic effects and for whichthere are diverse reports of whether pleasant or unpleasantdreams result during anaesthesia, post-operatively or aftersub-anaesthetic use. The aim was to assess in healthy volunteers the incidence o...

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Published in: Psychopharmacology
ISSN: 0033-3158 1432-2072
Published: 2009
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URI: https://cronfa.swan.ac.uk/Record/cronfa9003
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spelling 2019-06-13T15:43:37.8158114 v2 9003 2012-03-05 The incidence of unpleasant dreams after sub-anaesthetic ketamine 8c78ee008e650b9f0a463bae56a5636c 0000-0002-9854-1854 Mark Blagrove Mark Blagrove true false 2012-03-05 HPS Ketamine is an N-methyl-D-aspartate (NMDA)receptor antagonist with psychotogenic effects and for whichthere are diverse reports of whether pleasant or unpleasantdreams result during anaesthesia, post-operatively or aftersub-anaesthetic use. The aim was to assess in healthy volunteers the incidence ofunpleasant dreams over the three nights after receiving asub-anaesthetic dose of ketamine, in comparison to placebo,and with retrospective home nightmare frequency as acovariate.Thirty healthy volunteers completed questionnairesabout retrospective home dream recall and were then giveneither ketamine or placebo. Ketamine resulted in significantly more meandream unpleasantness relative to placebo and caused athreefold increase in the odds ratio for the incidence of anunpleasant dream. The number of dreams reported over thethree nights did not differ between the groups. Theincidence of unpleasant dreams after ketamine use waspredicted by retrospectively assessed nightmare frequencyat home.Ketamine causes unpleasant dreams over thethree post-administration nights. This may be evidence of aresidual psychotogenic effect that is not found on standardself-report symptomatology measures or a result of disturbedsleep electrophysiology. The results have theoretical implications for the relationship between nightmares and schizotypy. Journal Article Psychopharmacology 203 1 109 120 0033-3158 1432-2072 31 3 2009 2009-03-31 10.1007/s00213-008-1377-3 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University 2019-06-13T15:43:37.8158114 2012-03-05T11:42:36.1905676 Faculty of Medicine, Health and Life Sciences School of Psychology Mark Blagrove 0000-0002-9854-1854 1 Celia J. A Morgan 2 H. Valerie Curran 3 Leslie Bromley 4 Brigitte Brandner 5
title The incidence of unpleasant dreams after sub-anaesthetic ketamine
spellingShingle The incidence of unpleasant dreams after sub-anaesthetic ketamine
Mark Blagrove
title_short The incidence of unpleasant dreams after sub-anaesthetic ketamine
title_full The incidence of unpleasant dreams after sub-anaesthetic ketamine
title_fullStr The incidence of unpleasant dreams after sub-anaesthetic ketamine
title_full_unstemmed The incidence of unpleasant dreams after sub-anaesthetic ketamine
title_sort The incidence of unpleasant dreams after sub-anaesthetic ketamine
author_id_str_mv 8c78ee008e650b9f0a463bae56a5636c
author_id_fullname_str_mv 8c78ee008e650b9f0a463bae56a5636c_***_Mark Blagrove
author Mark Blagrove
author2 Mark Blagrove
Celia J. A Morgan
H. Valerie Curran
Leslie Bromley
Brigitte Brandner
format Journal article
container_title Psychopharmacology
container_volume 203
container_issue 1
container_start_page 109
publishDate 2009
institution Swansea University
issn 0033-3158
1432-2072
doi_str_mv 10.1007/s00213-008-1377-3
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 0
active_str 0
description Ketamine is an N-methyl-D-aspartate (NMDA)receptor antagonist with psychotogenic effects and for whichthere are diverse reports of whether pleasant or unpleasantdreams result during anaesthesia, post-operatively or aftersub-anaesthetic use. The aim was to assess in healthy volunteers the incidence ofunpleasant dreams over the three nights after receiving asub-anaesthetic dose of ketamine, in comparison to placebo,and with retrospective home nightmare frequency as acovariate.Thirty healthy volunteers completed questionnairesabout retrospective home dream recall and were then giveneither ketamine or placebo. Ketamine resulted in significantly more meandream unpleasantness relative to placebo and caused athreefold increase in the odds ratio for the incidence of anunpleasant dream. The number of dreams reported over thethree nights did not differ between the groups. Theincidence of unpleasant dreams after ketamine use waspredicted by retrospectively assessed nightmare frequencyat home.Ketamine causes unpleasant dreams over thethree post-administration nights. This may be evidence of aresidual psychotogenic effect that is not found on standardself-report symptomatology measures or a result of disturbedsleep electrophysiology. The results have theoretical implications for the relationship between nightmares and schizotypy.
published_date 2009-03-31T03:10:51Z
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score 11.03559

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