Journal article 940 views
Triclosan anatagonizes fluconazole activity against candida albicans
Journal of Dental Research, Volume: 91, Issue: 1, Pages: 65 - 70
Swansea University Authors:
Steven Kelly , Claire Hull
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DOI (Published version): 10.1177/0022034511425046
Abstract
Triclosan is a broad-spectrum antimicrobial compound commonly used in oral hygiene products. Investigation of its activity against Candida albicans showed that triclosan was fungicidal at concentrations of 16 mg/L. However, at subinhibitory concentrations (0.5-2 mg/L), triclosan antagonized the acti...
Published in: | Journal of Dental Research |
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2012
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URI: | https://cronfa.swan.ac.uk/Record/cronfa10166 |
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2021-10-26T17:00:59.9613887 v2 10166 2012-03-21 Triclosan anatagonizes fluconazole activity against candida albicans b17cebaf09b4d737b9378a3581e3de93 0000-0001-7991-5040 Steven Kelly Steven Kelly true false 6c495cb489b67bc9bb3f746975c4ff19 Claire Hull Claire Hull true false 2012-03-21 BMS Triclosan is a broad-spectrum antimicrobial compound commonly used in oral hygiene products. Investigation of its activity against Candida albicans showed that triclosan was fungicidal at concentrations of 16 mg/L. However, at subinhibitory concentrations (0.5-2 mg/L), triclosan antagonized the activity of fluconazole. Although triclosan induced CDR1 expression in C. albicans, antagonism was still observed in cdr1 Delta and cdr2 Delta strains. Triclosan did not affect fluconazole uptake or alter total membrane sterol content, but did induce the expression of FAS1 and FAS2, indicating that its mode of action may involve inhibition of fatty acid synthesis, as it does in prokaryotes. However, FAS2 mutants did not exhibit increased susceptibility to triclosan, and overexpression of both FAS1 and FAS2 alleles did not alter triclosan susceptibility. Unexpectedly, the antagonistic effect was specific for C. albicans under hypha-inducing conditions and was absent in the non-filamentous efg1 Delta strain. This antagonism may be due to the membranotropic activity of triclosan and the unique composition of hyphal membranes. Journal Article Journal of Dental Research 91 1 65 70 triclosan; fluconazole; antagonism; Candida albicans; EFG1; hyphae 31 12 2012 2012-12-31 10.1177/0022034511425046 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2021-10-26T17:00:59.9613887 2012-03-21T16:17:17.0000000 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine J Higgins 1 E Pinjon 2 HN Oltean 3 TC White 4 Steven Kelly 0000-0001-7991-5040 5 CM Martel 6 DJ Sulivan 7 DC Coleman 8 GP Moran 9 Claire Hull 10 |
title |
Triclosan anatagonizes fluconazole activity against candida albicans |
spellingShingle |
Triclosan anatagonizes fluconazole activity against candida albicans Steven Kelly Claire Hull |
title_short |
Triclosan anatagonizes fluconazole activity against candida albicans |
title_full |
Triclosan anatagonizes fluconazole activity against candida albicans |
title_fullStr |
Triclosan anatagonizes fluconazole activity against candida albicans |
title_full_unstemmed |
Triclosan anatagonizes fluconazole activity against candida albicans |
title_sort |
Triclosan anatagonizes fluconazole activity against candida albicans |
author_id_str_mv |
b17cebaf09b4d737b9378a3581e3de93 6c495cb489b67bc9bb3f746975c4ff19 |
author_id_fullname_str_mv |
b17cebaf09b4d737b9378a3581e3de93_***_Steven Kelly 6c495cb489b67bc9bb3f746975c4ff19_***_Claire Hull |
author |
Steven Kelly Claire Hull |
author2 |
J Higgins E Pinjon HN Oltean TC White Steven Kelly CM Martel DJ Sulivan DC Coleman GP Moran Claire Hull |
format |
Journal article |
container_title |
Journal of Dental Research |
container_volume |
91 |
container_issue |
1 |
container_start_page |
65 |
publishDate |
2012 |
institution |
Swansea University |
doi_str_mv |
10.1177/0022034511425046 |
college_str |
Faculty of Medicine, Health and Life Sciences |
hierarchytype |
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facultyofmedicinehealthandlifesciences |
hierarchy_top_title |
Faculty of Medicine, Health and Life Sciences |
hierarchy_parent_id |
facultyofmedicinehealthandlifesciences |
hierarchy_parent_title |
Faculty of Medicine, Health and Life Sciences |
department_str |
Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
document_store_str |
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active_str |
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description |
Triclosan is a broad-spectrum antimicrobial compound commonly used in oral hygiene products. Investigation of its activity against Candida albicans showed that triclosan was fungicidal at concentrations of 16 mg/L. However, at subinhibitory concentrations (0.5-2 mg/L), triclosan antagonized the activity of fluconazole. Although triclosan induced CDR1 expression in C. albicans, antagonism was still observed in cdr1 Delta and cdr2 Delta strains. Triclosan did not affect fluconazole uptake or alter total membrane sterol content, but did induce the expression of FAS1 and FAS2, indicating that its mode of action may involve inhibition of fatty acid synthesis, as it does in prokaryotes. However, FAS2 mutants did not exhibit increased susceptibility to triclosan, and overexpression of both FAS1 and FAS2 alleles did not alter triclosan susceptibility. Unexpectedly, the antagonistic effect was specific for C. albicans under hypha-inducing conditions and was absent in the non-filamentous efg1 Delta strain. This antagonism may be due to the membranotropic activity of triclosan and the unique composition of hyphal membranes. |
published_date |
2012-12-31T03:11:32Z |
_version_ |
1763750018264596480 |
score |
11.021648 |