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Lipopolysaccharide Initiates Inflammation in Bovine Granulosa Cells via the TLR4 Pathway and Perturbs Oocyte Meiotic Progression in Vitro / J. J Bromfield; I. M Sheldon

Endocrinology, Volume: 152, Issue: 12, Pages: 5029 - 5040

Swansea University Author: Sheldon, Martin

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DOI (Published version): 10.1210/en.2011-1124

Abstract

Uncovers the mechanism of how ovarian follicles can respond to bacterial infections at a distant site.Granulosa cells of ovarian follicles have innate immune capabilities.First report in any species of LPS toxin of Gram-negative bacteria causing direct damage to oocytes.

Published in: Endocrinology
ISSN: 0013-7227
Published: 2011
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URI: https://cronfa.swan.ac.uk/Record/cronfa10278
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Abstract: Uncovers the mechanism of how ovarian follicles can respond to bacterial infections at a distant site.Granulosa cells of ovarian follicles have innate immune capabilities.First report in any species of LPS toxin of Gram-negative bacteria causing direct damage to oocytes.
Item Description: Sheldon designed and led the research; did some of experiments; did analysis and wrote the paper with Dr Bromfield
Keywords: Innate immunity; ovary; oocyte
College: Swansea University Medical School
Issue: 12
Start Page: 5029
End Page: 5040