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Lipopolysaccharide Initiates Inflammation in Bovine Granulosa Cells via the TLR4 Pathway and Perturbs Oocyte Meiotic Progression in Vitro

J. J Bromfield, I. M Sheldon, Martin Sheldon Orcid Logo, John Bromfield

Endocrinology, Volume: 152, Issue: 12, Pages: 5029 - 5040

Swansea University Authors: Martin Sheldon Orcid Logo, John Bromfield

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DOI (Published version): 10.1210/en.2011-1124

Abstract

Uncovers the mechanism of how ovarian follicles can respond to bacterial infections at a distant site.Granulosa cells of ovarian follicles have innate immune capabilities.First report in any species of LPS toxin of Gram-negative bacteria causing direct damage to oocytes.

Published in: Endocrinology
ISSN: 0013-7227
Published: 2011
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa10278
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first_indexed 2013-07-23T12:03:08Z
last_indexed 2018-02-09T04:38:55Z
id cronfa10278
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spelling 2015-02-11T15:21:24.5464880 v2 10278 2012-03-21 Lipopolysaccharide Initiates Inflammation in Bovine Granulosa Cells via the TLR4 Pathway and Perturbs Oocyte Meiotic Progression in Vitro ab0f74b794e59cc270c69e63ee1d9748 0000-0001-7902-5558 Martin Sheldon Martin Sheldon true false 441f976bd4e213e7e51be16c301fb67b John Bromfield John Bromfield true false 2012-03-21 BMS Uncovers the mechanism of how ovarian follicles can respond to bacterial infections at a distant site.Granulosa cells of ovarian follicles have innate immune capabilities.First report in any species of LPS toxin of Gram-negative bacteria causing direct damage to oocytes. Journal Article Endocrinology 152 12 5029 5040 0013-7227 Innate immunity; ovary; oocyte 31 12 2011 2011-12-31 10.1210/en.2011-1124 Sheldon designed and led the research; did some of experiments; did analysis and wrote the paper with Dr Bromfield COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2015-02-11T15:21:24.5464880 2012-03-21T16:17:25.0000000 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine J. J Bromfield 1 I. M Sheldon 2 Martin Sheldon 0000-0001-7902-5558 3 John Bromfield 4
title Lipopolysaccharide Initiates Inflammation in Bovine Granulosa Cells via the TLR4 Pathway and Perturbs Oocyte Meiotic Progression in Vitro
spellingShingle Lipopolysaccharide Initiates Inflammation in Bovine Granulosa Cells via the TLR4 Pathway and Perturbs Oocyte Meiotic Progression in Vitro
Martin Sheldon
John Bromfield
title_short Lipopolysaccharide Initiates Inflammation in Bovine Granulosa Cells via the TLR4 Pathway and Perturbs Oocyte Meiotic Progression in Vitro
title_full Lipopolysaccharide Initiates Inflammation in Bovine Granulosa Cells via the TLR4 Pathway and Perturbs Oocyte Meiotic Progression in Vitro
title_fullStr Lipopolysaccharide Initiates Inflammation in Bovine Granulosa Cells via the TLR4 Pathway and Perturbs Oocyte Meiotic Progression in Vitro
title_full_unstemmed Lipopolysaccharide Initiates Inflammation in Bovine Granulosa Cells via the TLR4 Pathway and Perturbs Oocyte Meiotic Progression in Vitro
title_sort Lipopolysaccharide Initiates Inflammation in Bovine Granulosa Cells via the TLR4 Pathway and Perturbs Oocyte Meiotic Progression in Vitro
author_id_str_mv ab0f74b794e59cc270c69e63ee1d9748
441f976bd4e213e7e51be16c301fb67b
author_id_fullname_str_mv ab0f74b794e59cc270c69e63ee1d9748_***_Martin Sheldon
441f976bd4e213e7e51be16c301fb67b_***_John Bromfield
author Martin Sheldon
John Bromfield
author2 J. J Bromfield
I. M Sheldon
Martin Sheldon
John Bromfield
format Journal article
container_title Endocrinology
container_volume 152
container_issue 12
container_start_page 5029
publishDate 2011
institution Swansea University
issn 0013-7227
doi_str_mv 10.1210/en.2011-1124
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
active_str 0
description Uncovers the mechanism of how ovarian follicles can respond to bacterial infections at a distant site.Granulosa cells of ovarian follicles have innate immune capabilities.First report in any species of LPS toxin of Gram-negative bacteria causing direct damage to oocytes.
published_date 2011-12-31T03:11:38Z
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score 11.017797

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