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Mammalian Cell HPRT Gene Mutation Assay: Test Methods

George Johnson Orcid Logo

Methods in Molecular Biology, Volume: 817, Pages: 55 - 67

Swansea University Author: George Johnson Orcid Logo

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Published in: Methods in Molecular Biology
ISBN: 978-1-61779-420-9 978-1-61779-421-6
ISSN: 1064-3745 1940-6029
Published: New York Springer 2012
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Item Description: This chapter has become the standard operating procedure for EU laboratories to carry our the HPRT assay for submission to the European Chemicals Agency under REACH. This is leading to citations (2 since January 2012), and 125 chapter sales in the last 90 days at 40 Euro each. It will have high impact for REACH and laboratories to carry out this necessary experiment when carrying out hazard and risk assessment on the 40,000 or so chemicals submitted to REACH.
Keywords: HPRT gene mutation; Human cells; Mammalian cell mutation; Mutation testing
College: Faculty of Medicine, Health and Life Sciences
Start Page: 55
End Page: 67