Journal article 1265 views
Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus
,
K Li,
H Ireland,
Steve Bain,
Steve Hurel,
J Cooper,
Steve Humphries,
Jeffrey Stephens
Nutrition, Metabolism & Cardiovascular Diseases, Volume: 22, Issue: 5, Pages: 417 - 425
Swansea University Authors:
Sarah Prior , Jeffrey Stephens
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DOI (Published version): 10.1016/j.numecd.2010.08.001
Abstract
Glutathione peroxidase-1 (GPx-1) is an endogenous anti-oxidant enzyme. The T allele of the GPx-1 rs1050450 (C > T) gene variant is associated with reduced enzyme activity. Our aim was to examine the association between this gene variant and peripheral neuropathy in two cross-sectional sample...
| Published in: | Nutrition, Metabolism & Cardiovascular Diseases |
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| Published: |
2010
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| Online Access: |
http://www.nmcd-journal.com/article/S0939-4753(10)00188-2/abstract |
| URI: | https://cronfa.swan.ac.uk/Record/cronfa10734 |
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| Abstract: |
Glutathione peroxidase-1 (GPx-1) is an endogenous anti-oxidant enzyme. The T allele of the GPx-1 rs1050450 (C > T) gene variant is associated with reduced enzyme activity. Our aim was to examine the association between this gene variant and peripheral neuropathy in two cross-sectional samples of subjects with diabetes: (i) 773 Caucasian subjects were genotyped from the UCL Diabetes and Cardiovascular disease Study (UDACS) and (ii) 382 Caucasian subjects from the Ealing Diabetes Study (EDS). Peripheral neuropathy status (and oxidised-LDL [Ox-LDL:LDL] and plasma Total Ant-ioxidant Status [TAOS] in UDACS), were analysed in relation to genotype. We observed that: (i) In UDACS, the odds ratio (OR) for peripheral neuropathy in the T allele carriers compared to the CC genotype was 1.61 [1.10–2.28], p = 0.01. This remained significant after adjustment for other risk factors. Ox-LDL:LDL ratio was significantly elevated in T allele carriers (CC vs. CT/TT: 16.3 ± 2.4 v 18.0 ± 2.9 U/mmol LDL, p = 0.02). (ii) In EDS, the OR for peripheral neuropathy in the T allele carriers compared to the CC genotype was 1.95 [1.11–3.42], p = 0.02. This remained significant after adjustment for other risk factors. In conclusion, we observed a significant association between the T allele and peripheral neuropathy and LDL oxidation. This is the first paper to examine the rs1050450 variant in two samples of Caucasian subjects with diabetes. Prospective analysis of the gene variant is required in diabetic and healthy cohorts with measured plasma markers of oxidative stress to investigate the described association further. |
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| Keywords: |
Glutathione peroxidase; Oxidative stress; Diabetes; Peripheral neuropathy; Total anti-oxidant status |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
5 |
| Start Page: |
417 |
| End Page: |
425 |