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Targeted Metabolomics for Biomarker Discovery
Angewandte Chemie International Edition, Volume: 49, Issue: 32, Pages: 5426 - 5445
Swansea University Author:
William Griffiths
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1002/anie.200905579
Abstract
Metabolomics is a truly interdisciplinary field of science, which combines analytical chemistry, platform technology, mass spectrometry, and NMR spectroscopy with sophisticated data analysis. Applied to biomarker discovery, it includes aspects of pathobiochemistry, systems biology/medicine, and mole...
| Published in: | Angewandte Chemie International Edition |
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| ISSN: | 1433-7851 |
| Published: |
2010
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa10764 |
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| Abstract: |
Metabolomics is a truly interdisciplinary field of science, which combines analytical chemistry, platform technology, mass spectrometry, and NMR spectroscopy with sophisticated data analysis. Applied to biomarker discovery, it includes aspects of pathobiochemistry, systems biology/medicine, and molecular diagnostics and requires bioinformatics and multivariate statistics. While successfully established in the screening of inborn errors in neonates, metabolomics is now widely used in the characterization and diagnostic research of an ever increasing number of diseases. In this Review we highlight important technical prerequisites as well as recent developments in metabolomics and metabolomics data analysis with special emphasis on their utility in biomarker identification and qualification, as well as targeted metabolomics by employing high-throughput mass spectrometry. |
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| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
32 |
| Start Page: |
5426 |
| End Page: |
5445 |