No Cover Image

Other 365 views

Targeted Metabolomics for Biomarker Discovery / William J Griffiths; Therese Koal; Yuqin Wang; Matthias Kohl; David P Enot; Hans-Peter Deigner; William Griffiths

Angewandte Chemie International Edition, Volume: 49, Issue: 32, Pages: 5426 - 5445

Swansea University Author: William, Griffiths

Full text not available from this repository: check for access using links below.

Check full text

DOI (Published version): 10.1002/anie.200905579

Abstract

Metabolomics is a truly interdisciplinary field of science, which combines analytical chemistry, platform technology, mass spectrometry, and NMR spectroscopy with sophisticated data analysis. Applied to biomarker discovery, it includes aspects of pathobiochemistry, systems biology/medicine, and mole...

Full description

Published in: Angewandte Chemie International Edition
ISSN: 1433-7851
Published: 2010
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa10764
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: Metabolomics is a truly interdisciplinary field of science, which combines analytical chemistry, platform technology, mass spectrometry, and NMR spectroscopy with sophisticated data analysis. Applied to biomarker discovery, it includes aspects of pathobiochemistry, systems biology/medicine, and molecular diagnostics and requires bioinformatics and multivariate statistics. While successfully established in the screening of inborn errors in neonates, metabolomics is now widely used in the characterization and diagnostic research of an ever increasing number of diseases. In this Review we highlight important technical prerequisites as well as recent developments in metabolomics and metabolomics data analysis with special emphasis on their utility in biomarker identification and qualification, as well as targeted metabolomics by employing high-throughput mass spectrometry.
College: Swansea University Medical School
Issue: 32
Start Page: 5426
End Page: 5445