No Cover Image

Journal article 397 views

Cardiac Troponin I in Isoproterenol-Induced Cardiac Injury in the Hanover Wistar Rat: Studies on Low Dose Levels and Routes of Administration / William, Griffiths

Toxicologic Pathology, Volume: 38, Issue: 2, Pages: 287 - 291

Swansea University Author: William, Griffiths

Full text not available from this repository: check for access using links below.

Abstract

The current studies demonstrate the effect of low-dose intraperitoneal (IP) administration of isoprotenerol (ISO) and subcutaneous (SC) versus IP routes of administration of ISO on serum cardiac troponin I (cTnI) levels in female Hanover Wistar rats, providing additional evidence to support acceptan...

Full description

Published in: Toxicologic Pathology
ISSN: 0192-6233 1533-1601
Published: 2010
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa10939
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: The current studies demonstrate the effect of low-dose intraperitoneal (IP) administration of isoprotenerol (ISO) and subcutaneous (SC) versus IP routes of administration of ISO on serum cardiac troponin I (cTnI) levels in female Hanover Wistar rats, providing additional evidence to support acceptance of cTnI as a cardiac biomarker. At 2 hr postdosing with 0-500 μg/kg ISO, mean serum cTnI levels were increased in a dose-related fashion at ≥10 μg/kg with no evidence of cardiac pathology. At 24 h, cTnI concentrations were generally at control levels, but histologic cardiomyocyte injury was evident in a proportion of the animals given ≥10 μg/kg. In a second experiment, rats given SC ISO at 5,000 μg/kg and necropsied at 0, 1, 2, and 4 hr postdosing had higher levels of serum cTnI than animals given the same dose IP.
College: Swansea University Medical School
Issue: 2
Start Page: 287
End Page: 291