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Cardiac Troponin I in Isoproterenol-Induced Cardiac Injury in the Hanover Wistar Rat: Studies on Low Dose Levels and Routes of Administration
Toxicologic Pathology, Volume: 38, Issue: 2, Pages: 287 - 291
Swansea University Author: William Griffiths
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DOI (Published version): 10.1177/0192623309357948
Abstract
The current studies demonstrate the effect of low-dose intraperitoneal (IP) administration of isoprotenerol (ISO) and subcutaneous (SC) versus IP routes of administration of ISO on serum cardiac troponin I (cTnI) levels in female Hanover Wistar rats, providing additional evidence to support acceptan...
Published in: | Toxicologic Pathology |
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ISSN: | 0192-6233 1533-1601 |
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2010
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URI: | https://cronfa.swan.ac.uk/Record/cronfa10939 |
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2011-10-01T00:00:00.0000000 v2 10939 2012-06-05 Cardiac Troponin I in Isoproterenol-Induced Cardiac Injury in the Hanover Wistar Rat: Studies on Low Dose Levels and Routes of Administration 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2012-06-05 BMS The current studies demonstrate the effect of low-dose intraperitoneal (IP) administration of isoprotenerol (ISO) and subcutaneous (SC) versus IP routes of administration of ISO on serum cardiac troponin I (cTnI) levels in female Hanover Wistar rats, providing additional evidence to support acceptance of cTnI as a cardiac biomarker. At 2 hr postdosing with 0-500 μg/kg ISO, mean serum cTnI levels were increased in a dose-related fashion at ≥10 μg/kg with no evidence of cardiac pathology. At 24 h, cTnI concentrations were generally at control levels, but histologic cardiomyocyte injury was evident in a proportion of the animals given ≥10 μg/kg. In a second experiment, rats given SC ISO at 5,000 μg/kg and necropsied at 0, 1, 2, and 4 hr postdosing had higher levels of serum cTnI than animals given the same dose IP. Journal Article Toxicologic Pathology 38 2 287 291 0192-6233 1533-1601 31 12 2010 2010-12-31 10.1177/0192623309357948 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2011-10-01T00:00:00.0000000 2012-06-05T15:31:37.4368320 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine S Brady 1 M York 2 C Scudamore 3 T Williams 4 W Griffiths 5 J Turton 6 William Griffiths 0000-0002-4129-6616 7 |
title |
Cardiac Troponin I in Isoproterenol-Induced Cardiac Injury in the Hanover Wistar Rat: Studies on Low Dose Levels and Routes of Administration |
spellingShingle |
Cardiac Troponin I in Isoproterenol-Induced Cardiac Injury in the Hanover Wistar Rat: Studies on Low Dose Levels and Routes of Administration William Griffiths |
title_short |
Cardiac Troponin I in Isoproterenol-Induced Cardiac Injury in the Hanover Wistar Rat: Studies on Low Dose Levels and Routes of Administration |
title_full |
Cardiac Troponin I in Isoproterenol-Induced Cardiac Injury in the Hanover Wistar Rat: Studies on Low Dose Levels and Routes of Administration |
title_fullStr |
Cardiac Troponin I in Isoproterenol-Induced Cardiac Injury in the Hanover Wistar Rat: Studies on Low Dose Levels and Routes of Administration |
title_full_unstemmed |
Cardiac Troponin I in Isoproterenol-Induced Cardiac Injury in the Hanover Wistar Rat: Studies on Low Dose Levels and Routes of Administration |
title_sort |
Cardiac Troponin I in Isoproterenol-Induced Cardiac Injury in the Hanover Wistar Rat: Studies on Low Dose Levels and Routes of Administration |
author_id_str_mv |
3316b1d1b524be1831790933eed1c26e |
author_id_fullname_str_mv |
3316b1d1b524be1831790933eed1c26e_***_William Griffiths |
author |
William Griffiths |
author2 |
S Brady M York C Scudamore T Williams W Griffiths J Turton William Griffiths |
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Journal article |
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Toxicologic Pathology |
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38 |
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2 |
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287 |
publishDate |
2010 |
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Swansea University |
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0192-6233 1533-1601 |
doi_str_mv |
10.1177/0192623309357948 |
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Faculty of Medicine, Health and Life Sciences |
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facultyofmedicinehealthandlifesciences |
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Faculty of Medicine, Health and Life Sciences |
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facultyofmedicinehealthandlifesciences |
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Faculty of Medicine, Health and Life Sciences |
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Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
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description |
The current studies demonstrate the effect of low-dose intraperitoneal (IP) administration of isoprotenerol (ISO) and subcutaneous (SC) versus IP routes of administration of ISO on serum cardiac troponin I (cTnI) levels in female Hanover Wistar rats, providing additional evidence to support acceptance of cTnI as a cardiac biomarker. At 2 hr postdosing with 0-500 μg/kg ISO, mean serum cTnI levels were increased in a dose-related fashion at ≥10 μg/kg with no evidence of cardiac pathology. At 24 h, cTnI concentrations were generally at control levels, but histologic cardiomyocyte injury was evident in a proportion of the animals given ≥10 μg/kg. In a second experiment, rats given SC ISO at 5,000 μg/kg and necropsied at 0, 1, 2, and 4 hr postdosing had higher levels of serum cTnI than animals given the same dose IP. |
published_date |
2010-12-31T03:12:29Z |
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1763750077708369920 |
score |
11.028886 |