Journal article 107 views
Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis
Frédéric Pendino,
Eric Nguyen,
Inge Jonassen,
Bjarte Dysvik,
Abdulkader Azouz,
Michel Lanotte,
Evelyne Ségal-Bendirdjian,
Johan R. Lillehaug
Blood, Volume: 113, Issue: 14, Pages: 3172 - 3181
Swansea University Author: Abdulkader Azouz
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DOI (Published version): 10.1182/blood-2008-07-170035
Abstract
Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), tha...
| Published in: | Blood |
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| ISSN: | 0006-4971 1528-0020 |
| Published: |
American Society of Hematology
2009
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa12649 |
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| Abstract: |
Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), that contains a CXXC-type zinc-finger motif. RINF expression correlates with retinoid-induced differentiation of leukemic cells and with cytokine-induced myelopoiesis of normal CD34+ progenitors. Furthermore, short hairpin RNA (shRNA) interference suggests for this gene a regulatory function in both normal and tumoral myelopoiesis. Interestingly, RINF localizes to 5q31.3, a small region often deleted in myeloid leukemia (acute myeloid leukemia [AML]/myelodysplasia [MDS]) and suspected to harbor one or several tumor suppressor gene. |
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| Keywords: |
genes, myelopoiesis, retinoids, tretinoin, cytokine, cd34 antigens, rna, acute promyelocytic leukemia |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
14 |
| Start Page: |
3172 |
| End Page: |
3181 |