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Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis
Frédéric Pendino,
Eric Nguyen,
Inge Jonassen,
Bjarte Dysvik,
Abdulkader Azouz,
Michel Lanotte,
Evelyne Ségal-Bendirdjian,
Johan R. Lillehaug
Blood, Volume: 113, Issue: 14, Pages: 3172 - 3181
Swansea University Author: Abdulkader Azouz
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DOI (Published version): 10.1182/blood-2008-07-170035
Abstract
Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), tha...
Published in: | Blood |
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ISSN: | 0006-4971 1528-0020 |
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American Society of Hematology
2009
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URI: | https://cronfa.swan.ac.uk/Record/cronfa12649 |
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2022-11-02T13:55:21.3615123 v2 12649 2012-09-11 Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis e94d1fcbea6b2f7761bd64ec02dfc8cb Abdulkader Azouz Abdulkader Azouz true false 2012-09-11 PMSC Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), that contains a CXXC-type zinc-finger motif. RINF expression correlates with retinoid-induced differentiation of leukemic cells and with cytokine-induced myelopoiesis of normal CD34+ progenitors. Furthermore, short hairpin RNA (shRNA) interference suggests for this gene a regulatory function in both normal and tumoral myelopoiesis. Interestingly, RINF localizes to 5q31.3, a small region often deleted in myeloid leukemia (acute myeloid leukemia [AML]/myelodysplasia [MDS]) and suspected to harbor one or several tumor suppressor gene. Journal Article Blood 113 14 3172 3181 American Society of Hematology 0006-4971 1528-0020 genes, myelopoiesis, retinoids, tretinoin, cytokine, cd34 antigens, rna, acute promyelocytic leukemia 2 4 2009 2009-04-02 10.1182/blood-2008-07-170035 COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2022-11-02T13:55:21.3615123 2012-09-11T12:11:04.1105559 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Frédéric Pendino 1 Eric Nguyen 2 Inge Jonassen 3 Bjarte Dysvik 4 Abdulkader Azouz 5 Michel Lanotte 6 Evelyne Ségal-Bendirdjian 7 Johan R. Lillehaug 8 |
title |
Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis |
spellingShingle |
Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis Abdulkader Azouz |
title_short |
Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis |
title_full |
Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis |
title_fullStr |
Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis |
title_full_unstemmed |
Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis |
title_sort |
Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis |
author_id_str_mv |
e94d1fcbea6b2f7761bd64ec02dfc8cb |
author_id_fullname_str_mv |
e94d1fcbea6b2f7761bd64ec02dfc8cb_***_Abdulkader Azouz |
author |
Abdulkader Azouz |
author2 |
Frédéric Pendino Eric Nguyen Inge Jonassen Bjarte Dysvik Abdulkader Azouz Michel Lanotte Evelyne Ségal-Bendirdjian Johan R. Lillehaug |
format |
Journal article |
container_title |
Blood |
container_volume |
113 |
container_issue |
14 |
container_start_page |
3172 |
publishDate |
2009 |
institution |
Swansea University |
issn |
0006-4971 1528-0020 |
doi_str_mv |
10.1182/blood-2008-07-170035 |
publisher |
American Society of Hematology |
college_str |
Faculty of Medicine, Health and Life Sciences |
hierarchytype |
|
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facultyofmedicinehealthandlifesciences |
hierarchy_top_title |
Faculty of Medicine, Health and Life Sciences |
hierarchy_parent_id |
facultyofmedicinehealthandlifesciences |
hierarchy_parent_title |
Faculty of Medicine, Health and Life Sciences |
department_str |
Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
document_store_str |
0 |
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description |
Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), that contains a CXXC-type zinc-finger motif. RINF expression correlates with retinoid-induced differentiation of leukemic cells and with cytokine-induced myelopoiesis of normal CD34+ progenitors. Furthermore, short hairpin RNA (shRNA) interference suggests for this gene a regulatory function in both normal and tumoral myelopoiesis. Interestingly, RINF localizes to 5q31.3, a small region often deleted in myeloid leukemia (acute myeloid leukemia [AML]/myelodysplasia [MDS]) and suspected to harbor one or several tumor suppressor gene. |
published_date |
2009-04-02T03:14:34Z |
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1763750208271810560 |
score |
11.0241995 |