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Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis

Frédéric Pendino, Eric Nguyen, Inge Jonassen, Bjarte Dysvik, Abdulkader Azouz, Michel Lanotte, Evelyne Ségal-Bendirdjian, Johan R. Lillehaug

Blood, Volume: 113, Issue: 14, Pages: 3172 - 3181

Swansea University Author: Abdulkader Azouz

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DOI (Published version): 10.1182/blood-2008-07-170035

Abstract

Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), tha...

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Published in: Blood
ISSN: 0006-4971 1528-0020
Published: American Society of Hematology 2009
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URI: https://cronfa.swan.ac.uk/Record/cronfa12649
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first_indexed 2022-11-02T13:55:19Z
last_indexed 2023-01-11T13:42:33Z
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spelling 2022-11-02T13:55:21.3615123 v2 12649 2012-09-11 Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis e94d1fcbea6b2f7761bd64ec02dfc8cb Abdulkader Azouz Abdulkader Azouz true false 2012-09-11 PMSC Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), that contains a CXXC-type zinc-finger motif. RINF expression correlates with retinoid-induced differentiation of leukemic cells and with cytokine-induced myelopoiesis of normal CD34+ progenitors. Furthermore, short hairpin RNA (shRNA) interference suggests for this gene a regulatory function in both normal and tumoral myelopoiesis. Interestingly, RINF localizes to 5q31.3, a small region often deleted in myeloid leukemia (acute myeloid leukemia [AML]/myelodysplasia [MDS]) and suspected to harbor one or several tumor suppressor gene. Journal Article Blood 113 14 3172 3181 American Society of Hematology 0006-4971 1528-0020 genes, myelopoiesis, retinoids, tretinoin, cytokine, cd34 antigens, rna, acute promyelocytic leukemia 2 4 2009 2009-04-02 10.1182/blood-2008-07-170035 COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2022-11-02T13:55:21.3615123 2012-09-11T12:11:04.1105559 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Frédéric Pendino 1 Eric Nguyen 2 Inge Jonassen 3 Bjarte Dysvik 4 Abdulkader Azouz 5 Michel Lanotte 6 Evelyne Ségal-Bendirdjian 7 Johan R. Lillehaug 8
title Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis
spellingShingle Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis
Abdulkader Azouz
title_short Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis
title_full Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis
title_fullStr Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis
title_full_unstemmed Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis
title_sort Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis
author_id_str_mv e94d1fcbea6b2f7761bd64ec02dfc8cb
author_id_fullname_str_mv e94d1fcbea6b2f7761bd64ec02dfc8cb_***_Abdulkader Azouz
author Abdulkader Azouz
author2 Frédéric Pendino
Eric Nguyen
Inge Jonassen
Bjarte Dysvik
Abdulkader Azouz
Michel Lanotte
Evelyne Ségal-Bendirdjian
Johan R. Lillehaug
format Journal article
container_title Blood
container_volume 113
container_issue 14
container_start_page 3172
publishDate 2009
institution Swansea University
issn 0006-4971
1528-0020
doi_str_mv 10.1182/blood-2008-07-170035
publisher American Society of Hematology
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
active_str 0
description Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), that contains a CXXC-type zinc-finger motif. RINF expression correlates with retinoid-induced differentiation of leukemic cells and with cytokine-induced myelopoiesis of normal CD34+ progenitors. Furthermore, short hairpin RNA (shRNA) interference suggests for this gene a regulatory function in both normal and tumoral myelopoiesis. Interestingly, RINF localizes to 5q31.3, a small region often deleted in myeloid leukemia (acute myeloid leukemia [AML]/myelodysplasia [MDS]) and suspected to harbor one or several tumor suppressor gene.
published_date 2009-04-02T03:14:34Z
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score 11.0241995

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