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Central Carbon Metabolic Pathways in Streptomyces

Geertje Van keulen, Jeroen Siebring, Lubbert Dijkhuizen, Geertje Van Keulen Orcid Logo

Streptomyces: Molecular Biology and Biotechnology, Pages: 105 - 123

Swansea University Author: Geertje Van Keulen Orcid Logo

Abstract

Streptomyces and other actinomycetes are fascinating soil bacteria of major economic importance. They produce 70% of antibiotics known to man and numerous other pharmaceuticals for treatment of, for example, cancer, a range of infections, high cholesterol, or have immunosuppressive activity. It is n...

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Published in: Streptomyces: Molecular Biology and Biotechnology
Published: Wymondham, Norfolk, UK Caister Academic Press 2011
Online Access: http://www.horizonpress.com/streptomyces
URI: https://cronfa.swan.ac.uk/Record/cronfa12932
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spelling 2011-10-01T00:00:00.0000000 v2 12932 2012-09-28 Central Carbon Metabolic Pathways in Streptomyces 6b2c798924ac19de63e2168d50b99425 0000-0002-6044-1575 Geertje Van Keulen Geertje Van Keulen true false 2012-09-28 BMS Streptomyces and other actinomycetes are fascinating soil bacteria of major economic importance. They produce 70% of antibiotics known to man and numerous other pharmaceuticals for treatment of, for example, cancer, a range of infections, high cholesterol, or have immunosuppressive activity. It is not surprising that the multitude of gene clusters encoding for the biosynthesis of known and unknown secondary metabolites in genome sequences of a wide range of actinomycetes have received much attention in the last few years. In contrast, there is much less understanding of primary metabolism and its control in actinomycetes, despite its importance as supply pathways of precursors for secondary metabolite production. This review describes current information on the central carbon metabolic pathways in streptomycetes, focussing on glycolysis, pentose phosphate pathway, Entner-Doudoroff pathway, gluconeogenesis, and the source of phosphate for phosphorylation reactions. In addition, recent developments providing a greater insight into links with secondary metabolism in Streptomyces are reviewed. Book chapter Streptomyces: Molecular Biology and Biotechnology 105 123 Caister Academic Press Wymondham, Norfolk, UK antibiotics, streptomyces, primary carbon metabolism, secondary carbon metabolism, bacteriology, microbiology, molecular microbiology, genomics 1 3 2011 2011-03-01 http://www.horizonpress.com/streptomyces COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2011-10-01T00:00:00.0000000 2012-09-28T14:52:45.1420788 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Geertje Van keulen 1 Jeroen Siebring 2 Lubbert Dijkhuizen 3 Geertje Van Keulen 0000-0002-6044-1575 4
title Central Carbon Metabolic Pathways in Streptomyces
spellingShingle Central Carbon Metabolic Pathways in Streptomyces
Geertje Van Keulen
title_short Central Carbon Metabolic Pathways in Streptomyces
title_full Central Carbon Metabolic Pathways in Streptomyces
title_fullStr Central Carbon Metabolic Pathways in Streptomyces
title_full_unstemmed Central Carbon Metabolic Pathways in Streptomyces
title_sort Central Carbon Metabolic Pathways in Streptomyces
author_id_str_mv 6b2c798924ac19de63e2168d50b99425
author_id_fullname_str_mv 6b2c798924ac19de63e2168d50b99425_***_Geertje Van Keulen
author Geertje Van Keulen
author2 Geertje Van keulen
Jeroen Siebring
Lubbert Dijkhuizen
Geertje Van Keulen
format Book chapter
container_title Streptomyces: Molecular Biology and Biotechnology
container_start_page 105
publishDate 2011
institution Swansea University
publisher Caister Academic Press
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://www.horizonpress.com/streptomyces
document_store_str 0
active_str 0
description Streptomyces and other actinomycetes are fascinating soil bacteria of major economic importance. They produce 70% of antibiotics known to man and numerous other pharmaceuticals for treatment of, for example, cancer, a range of infections, high cholesterol, or have immunosuppressive activity. It is not surprising that the multitude of gene clusters encoding for the biosynthesis of known and unknown secondary metabolites in genome sequences of a wide range of actinomycetes have received much attention in the last few years. In contrast, there is much less understanding of primary metabolism and its control in actinomycetes, despite its importance as supply pathways of precursors for secondary metabolite production. This review describes current information on the central carbon metabolic pathways in streptomycetes, focussing on glycolysis, pentose phosphate pathway, Entner-Doudoroff pathway, gluconeogenesis, and the source of phosphate for phosphorylation reactions. In addition, recent developments providing a greater insight into links with secondary metabolism in Streptomyces are reviewed.
published_date 2011-03-01T03:14:49Z
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score 11.03559

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