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Production of Specialized Metabolites by Streptomyces coelicolor A3(2) / Geertje van Keulen; Paul J. Dyson

Volume: 89, Pages: 217 - 266

Swansea University Author: Van Keulen, Geertje

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DOI (Published version): 10.1016/B978-0-12-800259-9.00006-8

Abstract

The actinomycetes are well-known bioactive natural product producers, comprising the Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic compounds for the areas of infection, cancer, circulation, and immunity. Completion and annotation of many actinomycete genomes...

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ISBN: 9780128002599
Published: Elsevier Inc 2014
Online Access: http://www.sciencedirect.com/science/article/pii/B9780128002599000068
URI: https://cronfa.swan.ac.uk/Record/cronfa18259
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Abstract: The actinomycetes are well-known bioactive natural product producers, comprising the Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic compounds for the areas of infection, cancer, circulation, and immunity. Completion and annotation of many actinomycete genomes has highlighted further how proficient these bacteria are in specialized metabolism, which have been largely underexploited in traditional screening programs. The genome sequence of the model strain Streptomyces coelicolor A3(2), and subsequent development of genomics-driven approaches to understand its large specialized metabolome, has been key in unlocking the high potential of specialized metabolites for natural product genomics-based drug discovery. This review discusses systematically the biochemistry and genetics of each of the specialized metabolites of S. coelicolor and describes metabolite transport processes for excretion and complex regulatory patterns controlling biosynthesis.© 2014 Elsevier Inc. All rights reserved.
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Keywords: Streptomyces coelicolor, specialized metabolism, natural products, biosynthesis, gene clusters, antibiotics, regulation, modulation, host, secondary metabolism
College: College of Medicine
Start Page: 217
End Page: 266