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Production of Specialized Metabolites by Streptomyces coelicolor A3(2) / Geertje van Keulen; Paul J. Dyson

Volume: 89, Pages: 217 - 266

Swansea University Author: Van Keulen, Geertje

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DOI (Published version): 10.1016/B978-0-12-800259-9.00006-8

Abstract

The actinomycetes are well-known bioactive natural product producers, comprising the Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic compounds for the areas of infection, cancer, circulation, and immunity. Completion and annotation of many actinomycete genomes...

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Published: Elsevier Inc 2014
Online Access: http://www.sciencedirect.com/science/article/pii/B9780128002599000068
URI: https://cronfa.swan.ac.uk/Record/cronfa18259
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spelling 2014-08-20T14:05:25Z v2 18259 2014-08-20 Production of Specialized Metabolites by Streptomyces coelicolor A3(2) Geertje Van Keulen Geertje Van Keulen true 0000-0002-6044-1575 false 6b2c798924ac19de63e2168d50b99425 9a9b1f5c7e5730932420ba55c1b56679 TMTpzy2phXvI6/CEdMyl7X2HZhUyFASdV1DFdgIIhKs= 2014-08-20 PMSC The actinomycetes are well-known bioactive natural product producers, comprising the Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic compounds for the areas of infection, cancer, circulation, and immunity. Completion and annotation of many actinomycete genomes has highlighted further how proficient these bacteria are in specialized metabolism, which have been largely underexploited in traditional screening programs. The genome sequence of the model strain Streptomyces coelicolor A3(2), and subsequent development of genomics-driven approaches to understand its large specialized metabolome, has been key in unlocking the high potential of specialized metabolites for natural product genomics-based drug discovery. This review discusses systematically the biochemistry and genetics of each of the specialized metabolites of S. coelicolor and describes metabolite transport processes for excretion and complex regulatory patterns controlling biosynthesis.© 2014 Elsevier Inc. All rights reserved. Chapter in book 89 217 266 Elsevier Inc Streptomyces coelicolor, specialized metabolism, natural products, biosynthesis, gene clusters, antibiotics, regulation, modulation, host, secondary metabolism 14 8 2014 2014-08-14 10.1016/B978-0-12-800259-9.00006-8 http://www.sciencedirect.com/science/article/pii/B9780128002599000068 - Swansea University Medical School Medicine CMED PMSC Sima Sariaslani and Geoffrey Michael Gadd None 2014-08-20T14:05:25Z 2014-08-20T14:01:52Z Swansea University Medical School Medicine Geertje van Keulen 1 Paul J. Dyson 2
title Production of Specialized Metabolites by Streptomyces coelicolor A3(2)
spellingShingle Production of Specialized Metabolites by Streptomyces coelicolor A3(2)
Van Keulen, Geertje
title_short Production of Specialized Metabolites by Streptomyces coelicolor A3(2)
title_full Production of Specialized Metabolites by Streptomyces coelicolor A3(2)
title_fullStr Production of Specialized Metabolites by Streptomyces coelicolor A3(2)
title_full_unstemmed Production of Specialized Metabolites by Streptomyces coelicolor A3(2)
title_sort Production of Specialized Metabolites by Streptomyces coelicolor A3(2)
author_id_str_mv 6b2c798924ac19de63e2168d50b99425
author_id_fullname_str_mv 6b2c798924ac19de63e2168d50b99425_***_Van Keulen, Geertje
author Van Keulen, Geertje
author2 Geertje van Keulen
Paul J. Dyson
format Book Chapter
container_volume 89
container_start_page 217
publishDate 2014
institution Swansea University
doi_str_mv 10.1016/B978-0-12-800259-9.00006-8
publisher Elsevier Inc
college_str Swansea University Medical School
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hierarchy_top_id swanseauniversitymedicalschool
hierarchy_top_title Swansea University Medical School
hierarchy_parent_id swanseauniversitymedicalschool
hierarchy_parent_title Swansea University Medical School
department_str Medicine{{{_:::_}}}Swansea University Medical School{{{_:::_}}}Medicine
url http://www.sciencedirect.com/science/article/pii/B9780128002599000068
document_store_str 0
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description The actinomycetes are well-known bioactive natural product producers, comprising the Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic compounds for the areas of infection, cancer, circulation, and immunity. Completion and annotation of many actinomycete genomes has highlighted further how proficient these bacteria are in specialized metabolism, which have been largely underexploited in traditional screening programs. The genome sequence of the model strain Streptomyces coelicolor A3(2), and subsequent development of genomics-driven approaches to understand its large specialized metabolome, has been key in unlocking the high potential of specialized metabolites for natural product genomics-based drug discovery. This review discusses systematically the biochemistry and genetics of each of the specialized metabolites of S. coelicolor and describes metabolite transport processes for excretion and complex regulatory patterns controlling biosynthesis.© 2014 Elsevier Inc. All rights reserved.
published_date 2014-08-14T21:09:48Z
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