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Individual Differences in Subconscious Motor Control Predicted by GABA Concentration in SMA

Frederic Boy Orcid Logo, C. John Evans, Richard A.E. Edden, Krish D. Singh, Masud Husain, Petroc Sumner

Current Biology, Volume: 20, Issue: 19, Pages: 1779 - 1785

Swansea University Author: Frederic Boy Orcid Logo

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DOI (Published version): 10.1016/j.cub.2010.09.003

Abstract

Subliminal visual stimuli affect motor planning [1], but the size of such effects differs greatly between individuals [2, 3]. Here, we investigated whether such variation may be related to neurochemical differences between people. Cortical responsiveness is expected to be lower under the influence o...

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Published in: Current Biology
ISSN: 0960-9822
Published: 2010
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa13373
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last_indexed 2018-02-09T04:44:04Z
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spelling 2015-06-16T12:44:47.4858772 v2 13373 2012-11-27 Individual Differences in Subconscious Motor Control Predicted by GABA Concentration in SMA 43e704698d5dbbac3734b7cd0fef60aa 0000-0003-1373-6634 Frederic Boy Frederic Boy true false 2012-11-27 BBU Subliminal visual stimuli affect motor planning [1], but the size of such effects differs greatly between individuals [2, 3]. Here, we investigated whether such variation may be related to neurochemical differences between people. Cortical responsiveness is expected to be lower under the influence of more of the main inhibitory neurotransmitter, GABA [4]. Thus, we hypothesized that, if an individual has more GABA in the supplementary motor area (SMA)—a region previously associated with automatic motor control [5]—this would result in smaller subliminal effects. We measured the reversed masked prime—or negative compat- ibility—effect, and found that it correlated strongly with GABA concentration, measured with magnetic resonance spectroscopy. This occurred specifically in the SMA region, and not in other regions from which spectroscopy measure- ments were taken. We replicated these results in an inde- pendent cohort: more GABA in the SMA region is reliably associated with smaller effect size. These findings suggest that, across individuals, the responsiveness of subcon- scious motor mechanisms is related to GABA concentration in the SMA. Journal Article Current Biology 20 19 1779 1785 0960-9822 GABA, Supplementary Motor Area, Individual differences 31 12 2010 2010-12-31 10.1016/j.cub.2010.09.003 COLLEGE NANME Business COLLEGE CODE BBU Swansea University 2015-06-16T12:44:47.4858772 2012-11-27T10:00:34.6516522 Faculty of Medicine, Health and Life Sciences School of Psychology Frederic Boy 0000-0003-1373-6634 1 C. John Evans 2 Richard A.E. Edden 3 Krish D. Singh 4 Masud Husain 5 Petroc Sumner 6
title Individual Differences in Subconscious Motor Control Predicted by GABA Concentration in SMA
spellingShingle Individual Differences in Subconscious Motor Control Predicted by GABA Concentration in SMA
Frederic Boy
title_short Individual Differences in Subconscious Motor Control Predicted by GABA Concentration in SMA
title_full Individual Differences in Subconscious Motor Control Predicted by GABA Concentration in SMA
title_fullStr Individual Differences in Subconscious Motor Control Predicted by GABA Concentration in SMA
title_full_unstemmed Individual Differences in Subconscious Motor Control Predicted by GABA Concentration in SMA
title_sort Individual Differences in Subconscious Motor Control Predicted by GABA Concentration in SMA
author_id_str_mv 43e704698d5dbbac3734b7cd0fef60aa
author_id_fullname_str_mv 43e704698d5dbbac3734b7cd0fef60aa_***_Frederic Boy
author Frederic Boy
author2 Frederic Boy
C. John Evans
Richard A.E. Edden
Krish D. Singh
Masud Husain
Petroc Sumner
format Journal article
container_title Current Biology
container_volume 20
container_issue 19
container_start_page 1779
publishDate 2010
institution Swansea University
issn 0960-9822
doi_str_mv 10.1016/j.cub.2010.09.003
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 0
active_str 0
description Subliminal visual stimuli affect motor planning [1], but the size of such effects differs greatly between individuals [2, 3]. Here, we investigated whether such variation may be related to neurochemical differences between people. Cortical responsiveness is expected to be lower under the influence of more of the main inhibitory neurotransmitter, GABA [4]. Thus, we hypothesized that, if an individual has more GABA in the supplementary motor area (SMA)—a region previously associated with automatic motor control [5]—this would result in smaller subliminal effects. We measured the reversed masked prime—or negative compat- ibility—effect, and found that it correlated strongly with GABA concentration, measured with magnetic resonance spectroscopy. This occurred specifically in the SMA region, and not in other regions from which spectroscopy measure- ments were taken. We replicated these results in an inde- pendent cohort: more GABA in the SMA region is reliably associated with smaller effect size. These findings suggest that, across individuals, the responsiveness of subcon- scious motor mechanisms is related to GABA concentration in the SMA.
published_date 2010-12-31T03:15:18Z
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score 11.012678

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