Journal article 659 views
Dorsolateral Prefrontal γ-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity / Frederic Boy; C. John Evans; Richard A.E. Edden; Andrew D. Lawrence; Krish D. Singh; Masud Husain; Petroc Sumner
Biological Psychiatry, Volume: 70, Issue: 9, Pages: 866 - 872
Swansea University Author: Frederic, Boy
Full text not available from this repository: check for access using links below.
Background: Impulsivity is a multifaceted personality construct associated with numerous psychiatric disorders. Recent research has characterized four facets of impulsivity: “urgency” (the tendency to act rashly especially in the context of distress or cravings); “lack of premeditation” (not envisag...
|Published in:||Biological Psychiatry|
Check full text
No Tags, Be the first to tag this record!
Background: Impulsivity is a multifaceted personality construct associated with numerous psychiatric disorders. Recent research has characterized four facets of impulsivity: “urgency” (the tendency to act rashly especially in the context of distress or cravings); “lack of premeditation” (not envisaging the consequences of actions); “lack of perseverance” (not staying focused on a task); and “sensation seeking” (engaging in exciting activities). Urgency is particularly associated with clinical populations and problematic disinhibited behavior.Methods: We used magnetic resonance spectroscopy to measure concentration of the inhibitory neurotransmitter -aminobutyric acid (GABA) in the dorsolateral prefrontal cortex (DLPFC) in two cohorts of 12 and 13 participants.Results: WefindthatvariationintraiturgencyinhealthymencorrelateswithGABAconcentrationintheDLPFC.Theresultwasreplicated in an independent cohort. More GABA predicted lower urgency scores, consistent with a role in self-control for GABA-mediated inhibitory mechanisms in DLPFC.Conclusions: These findings help account for individual differences in self-control and thus clarify the relationship between GABA and a wide range of psychiatric disorders associated with impaired self-control.
Externalizing, gamma-aminobutyric acid receptor alpha-2 (GABRA2), inhibition, neurochemistry, personality, self-control, stop-signal, urgency
College of Human and Health Sciences