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Dorsolateral Prefrontal γ-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity

Frederic Boy Orcid Logo, C. John Evans, Richard A.E. Edden, Andrew D. Lawrence, Krish D. Singh, Masud Husain, Petroc Sumner

Biological Psychiatry, Volume: 70, Issue: 9, Pages: 866 - 872

Swansea University Author: Frederic Boy Orcid Logo

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DOI (Published version): 10.1016/j.biopsych.2011.05.030

Abstract

Background: Impulsivity is a multifaceted personality construct associated with numerous psychiatric disorders. Recent research has characterized four facets of impulsivity: “urgency” (the tendency to act rashly especially in the context of distress or cravings); “lack of premeditation” (not envisag...

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Published in: Biological Psychiatry
ISSN: 0006-3223
Published: 2011
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URI: https://cronfa.swan.ac.uk/Record/cronfa13371
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2015-06-16T12:44:54.4277882</datestamp><bib-version>v2</bib-version><id>13371</id><entry>2012-11-27</entry><title>Dorsolateral Prefrontal &#x3B3;-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity</title><swanseaauthors><author><sid>43e704698d5dbbac3734b7cd0fef60aa</sid><ORCID>0000-0003-1373-6634</ORCID><firstname>Frederic</firstname><surname>Boy</surname><name>Frederic Boy</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2012-11-27</date><deptcode>BBU</deptcode><abstract>Background: Impulsivity is a multifaceted personality construct associated with numerous psychiatric disorders. Recent research has characterized four facets of impulsivity: &#x201C;urgency&#x201D; (the tendency to act rashly especially in the context of distress or cravings); &#x201C;lack of premeditation&#x201D; (not envisaging the consequences of actions); &#x201C;lack of perseverance&#x201D; (not staying focused on a task); and &#x201C;sensation seeking&#x201D; (engaging in exciting activities). Urgency is particularly associated with clinical populations and problematic disinhibited behavior.Methods: We used magnetic resonance spectroscopy to measure concentration of the inhibitory neurotransmitter -aminobutyric acid (GABA) in the dorsolateral prefrontal cortex (DLPFC) in two cohorts of 12 and 13 participants.Results: WefindthatvariationintraiturgencyinhealthymencorrelateswithGABAconcentrationintheDLPFC.Theresultwasreplicated in an independent cohort. More GABA predicted lower urgency scores, consistent with a role in self-control for GABA-mediated inhibitory mechanisms in DLPFC.Conclusions: These findings help account for individual differences in self-control and thus clarify the relationship between GABA and a wide range of psychiatric disorders associated with impaired self-control.</abstract><type>Journal Article</type><journal>Biological Psychiatry</journal><volume>70</volume><journalNumber>9</journalNumber><paginationStart>866</paginationStart><paginationEnd>872</paginationEnd><publisher/><issnPrint>0006-3223</issnPrint><issnElectronic/><keywords>Externalizing, gamma-aminobutyric acid receptor alpha-2 (GABRA2), inhibition, neurochemistry, personality, self-control, stop-signal, urgency</keywords><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2011</publishedYear><publishedDate>2011-12-31</publishedDate><doi>10.1016/j.biopsych.2011.05.030</doi><url/><notes/><college>COLLEGE NANME</college><department>Business</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BBU</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2015-06-16T12:44:54.4277882</lastEdited><Created>2012-11-27T09:58:15.8885114</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">School of Psychology</level></path><authors><author><firstname>Frederic</firstname><surname>Boy</surname><orcid>0000-0003-1373-6634</orcid><order>1</order></author><author><firstname>C. John</firstname><surname>Evans</surname><order>2</order></author><author><firstname>Richard A.E.</firstname><surname>Edden</surname><order>3</order></author><author><firstname>Andrew D.</firstname><surname>Lawrence</surname><order>4</order></author><author><firstname>Krish D.</firstname><surname>Singh</surname><order>5</order></author><author><firstname>Masud</firstname><surname>Husain</surname><order>6</order></author><author><firstname>Petroc</firstname><surname>Sumner</surname><order>7</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2015-06-16T12:44:54.4277882 v2 13371 2012-11-27 Dorsolateral Prefrontal γ-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity 43e704698d5dbbac3734b7cd0fef60aa 0000-0003-1373-6634 Frederic Boy Frederic Boy true false 2012-11-27 BBU Background: Impulsivity is a multifaceted personality construct associated with numerous psychiatric disorders. Recent research has characterized four facets of impulsivity: “urgency” (the tendency to act rashly especially in the context of distress or cravings); “lack of premeditation” (not envisaging the consequences of actions); “lack of perseverance” (not staying focused on a task); and “sensation seeking” (engaging in exciting activities). Urgency is particularly associated with clinical populations and problematic disinhibited behavior.Methods: We used magnetic resonance spectroscopy to measure concentration of the inhibitory neurotransmitter -aminobutyric acid (GABA) in the dorsolateral prefrontal cortex (DLPFC) in two cohorts of 12 and 13 participants.Results: WefindthatvariationintraiturgencyinhealthymencorrelateswithGABAconcentrationintheDLPFC.Theresultwasreplicated in an independent cohort. More GABA predicted lower urgency scores, consistent with a role in self-control for GABA-mediated inhibitory mechanisms in DLPFC.Conclusions: These findings help account for individual differences in self-control and thus clarify the relationship between GABA and a wide range of psychiatric disorders associated with impaired self-control. Journal Article Biological Psychiatry 70 9 866 872 0006-3223 Externalizing, gamma-aminobutyric acid receptor alpha-2 (GABRA2), inhibition, neurochemistry, personality, self-control, stop-signal, urgency 31 12 2011 2011-12-31 10.1016/j.biopsych.2011.05.030 COLLEGE NANME Business COLLEGE CODE BBU Swansea University 2015-06-16T12:44:54.4277882 2012-11-27T09:58:15.8885114 Faculty of Medicine, Health and Life Sciences School of Psychology Frederic Boy 0000-0003-1373-6634 1 C. John Evans 2 Richard A.E. Edden 3 Andrew D. Lawrence 4 Krish D. Singh 5 Masud Husain 6 Petroc Sumner 7
title Dorsolateral Prefrontal γ-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity
spellingShingle Dorsolateral Prefrontal γ-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity
Frederic Boy
title_short Dorsolateral Prefrontal γ-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity
title_full Dorsolateral Prefrontal γ-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity
title_fullStr Dorsolateral Prefrontal γ-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity
title_full_unstemmed Dorsolateral Prefrontal γ-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity
title_sort Dorsolateral Prefrontal γ-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity
author_id_str_mv 43e704698d5dbbac3734b7cd0fef60aa
author_id_fullname_str_mv 43e704698d5dbbac3734b7cd0fef60aa_***_Frederic Boy
author Frederic Boy
author2 Frederic Boy
C. John Evans
Richard A.E. Edden
Andrew D. Lawrence
Krish D. Singh
Masud Husain
Petroc Sumner
format Journal article
container_title Biological Psychiatry
container_volume 70
container_issue 9
container_start_page 866
publishDate 2011
institution Swansea University
issn 0006-3223
doi_str_mv 10.1016/j.biopsych.2011.05.030
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 0
active_str 0
description Background: Impulsivity is a multifaceted personality construct associated with numerous psychiatric disorders. Recent research has characterized four facets of impulsivity: “urgency” (the tendency to act rashly especially in the context of distress or cravings); “lack of premeditation” (not envisaging the consequences of actions); “lack of perseverance” (not staying focused on a task); and “sensation seeking” (engaging in exciting activities). Urgency is particularly associated with clinical populations and problematic disinhibited behavior.Methods: We used magnetic resonance spectroscopy to measure concentration of the inhibitory neurotransmitter -aminobutyric acid (GABA) in the dorsolateral prefrontal cortex (DLPFC) in two cohorts of 12 and 13 participants.Results: WefindthatvariationintraiturgencyinhealthymencorrelateswithGABAconcentrationintheDLPFC.Theresultwasreplicated in an independent cohort. More GABA predicted lower urgency scores, consistent with a role in self-control for GABA-mediated inhibitory mechanisms in DLPFC.Conclusions: These findings help account for individual differences in self-control and thus clarify the relationship between GABA and a wide range of psychiatric disorders associated with impaired self-control.
published_date 2011-12-31T03:15:18Z
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score 11.012678

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