No Cover Image

Journal article 465 views

Synthesis and biological activity of (24E)- and (24Z)-26-hydroxydesmosterol / Yuqin, Wang; William, Griffiths

Bioorganic & Medicinal Chemistry

Swansesa University Authors: Yuqin, Wang, William, Griffiths

Full text not available from this repository: check for access using links below.

Abstract

Using 3b-hydroxychol-5-en-24-oic acid (4) as starting material, the diastereoisomeric allylic alcohols (24E)-26-hydroxydesmosterol (2) and (24Z)-26-hydroxydesmosterol (3) have been synthesised in six steps with 67% and 12% overall yield, respectively. Both of these isomers are found in newborn mouse...

Full description

Published in: Bioorganic & Medicinal Chemistry
ISSN: 0968-0896
Published: 2013
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa15364
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: Using 3b-hydroxychol-5-en-24-oic acid (4) as starting material, the diastereoisomeric allylic alcohols (24E)-26-hydroxydesmosterol (2) and (24Z)-26-hydroxydesmosterol (3) have been synthesised in six steps with 67% and 12% overall yield, respectively. Both of these isomers are found in newborn mouse brain where sterol synthesis is high. Unlike desmosterol (1), neither of these isomers is a ligand to the liver x receptors and thus represents a novel biological deactivation mechanism avoiding cholesterol synthesis.
College: Swansea University Medical School