Journal article 1038 views
Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6
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Gareth Healey
PLoS ONE, Volume: 9, Issue: 2, Start page: e90338
Swansea University Authors:
William Walker , Gareth Healey
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DOI (Published version): 10.1371/journal.pone.0090338
Abstract
As the development of siRNA therapeutics is technically challenging, this study evaluates various pre-clinical models in their ability to suitably test candidate siRNA for respiratory administration. This study shows that use of chemically-modified siRNA was not associated with cellular toxicity, ye...
| Published in: | PLoS ONE |
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| Published: |
2014
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| Online Access: |
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090338 |
| URI: | https://cronfa.swan.ac.uk/Record/cronfa17428 |
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| Abstract: |
As the development of siRNA therapeutics is technically challenging, this study evaluates various pre-clinical models in their ability to suitably test candidate siRNA for respiratory administration. This study shows that use of chemically-modified siRNA was not associated with cellular toxicity, yet enhanced bio-availability without evidence of reduced efficacy. Furthermore, we established a robust, sensitive method for determining siRNA bio-distribution in vivo, and co-developed a novel nasal administration model to further aid evaluation. |
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| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
2 |
| Start Page: |
e90338 |