No Cover Image

Journal article 716 views

Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6 / William, Walker; Gareth, Healey

PLoS ONE, Volume: 9, Issue: 2, Start page: e90338

Swansea University Authors: William, Walker, Gareth, Healey

Full text not available from this repository: check for access using links below.

DOI (Published version): 10.1371/journal.pone.0090338

Abstract

As the development of siRNA therapeutics is technically challenging, this study evaluates various pre-clinical models in their ability to suitably test candidate siRNA for respiratory administration. This study shows that use of chemically-modified siRNA was not associated with cellular toxicity, ye...

Full description

Published in: PLoS ONE
Published: 2014
Online Access: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090338
URI: https://cronfa.swan.ac.uk/Record/cronfa17428
Tags: Add Tag
No Tags, Be the first to tag this record!
first_indexed 2014-03-05T02:30:03Z
last_indexed 2018-02-09T04:51:02Z
id cronfa17428
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2016-02-11T11:32:23.4702929</datestamp><bib-version>v2</bib-version><id>17428</id><entry>2014-03-04</entry><title>Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6</title><swanseaauthors><author><sid>1f736d4178747b6082940868d069894f</sid><ORCID>0000-0002-1940-5329</ORCID><firstname>William</firstname><surname>Walker</surname><name>William Walker</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>5926519f89187489cfd5e1478aa188b1</sid><ORCID>0000-0001-9531-1220</ORCID><firstname>Gareth</firstname><surname>Healey</surname><name>Gareth Healey</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2014-03-04</date><deptcode>BMS</deptcode><abstract>As the development of siRNA therapeutics is technically challenging, this study evaluates various pre-clinical models in their ability to suitably test candidate siRNA for respiratory administration. This study shows that use of chemically-modified siRNA was not associated with cellular toxicity, yet enhanced bio-availability without evidence of reduced efficacy. Furthermore, we established a robust, sensitive method for determining siRNA bio-distribution in vivo, and co-developed a novel nasal administration model to further aid evaluation.</abstract><type>Journal Article</type><journal>PLoS ONE</journal><volume>9</volume><journalNumber>2</journalNumber><paginationStart>e90338</paginationStart><publisher/><keywords/><publishedDay>28</publishedDay><publishedMonth>2</publishedMonth><publishedYear>2014</publishedYear><publishedDate>2014-02-28</publishedDate><doi>10.1371/journal.pone.0090338</doi><url>http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090338</url><notes/><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><lastEdited>2016-02-11T11:32:23.4702929</lastEdited><Created>2014-03-04T10:33:03.1936660</Created><path><level id="1">Swansea University Medical School</level><level id="2">Medicine</level></path><authors><author><firstname>William</firstname><surname>Walker</surname><orcid>0000-0002-1940-5329</orcid><order>1</order></author><author><firstname>Gareth</firstname><surname>Healey</surname><orcid>0000-0001-9531-1220</orcid><order>2</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2016-02-11T11:32:23.4702929 v2 17428 2014-03-04 Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6 1f736d4178747b6082940868d069894f 0000-0002-1940-5329 William Walker William Walker true false 5926519f89187489cfd5e1478aa188b1 0000-0001-9531-1220 Gareth Healey Gareth Healey true false 2014-03-04 BMS As the development of siRNA therapeutics is technically challenging, this study evaluates various pre-clinical models in their ability to suitably test candidate siRNA for respiratory administration. This study shows that use of chemically-modified siRNA was not associated with cellular toxicity, yet enhanced bio-availability without evidence of reduced efficacy. Furthermore, we established a robust, sensitive method for determining siRNA bio-distribution in vivo, and co-developed a novel nasal administration model to further aid evaluation. Journal Article PLoS ONE 9 2 e90338 28 2 2014 2014-02-28 10.1371/journal.pone.0090338 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090338 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2016-02-11T11:32:23.4702929 2014-03-04T10:33:03.1936660 Swansea University Medical School Medicine William Walker 0000-0002-1940-5329 1 Gareth Healey 0000-0001-9531-1220 2
title Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6
spellingShingle Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6
William, Walker
Gareth, Healey
title_short Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6
title_full Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6
title_fullStr Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6
title_full_unstemmed Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6
title_sort Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6
author_id_str_mv 1f736d4178747b6082940868d069894f
5926519f89187489cfd5e1478aa188b1
author_id_fullname_str_mv 1f736d4178747b6082940868d069894f_***_William, Walker
5926519f89187489cfd5e1478aa188b1_***_Gareth, Healey
author William, Walker
Gareth, Healey
format Journal article
container_title PLoS ONE
container_volume 9
container_issue 2
container_start_page e90338
publishDate 2014
institution Swansea University
doi_str_mv 10.1371/journal.pone.0090338
college_str Swansea University Medical School
hierarchytype
hierarchy_top_id swanseauniversitymedicalschool
hierarchy_top_title Swansea University Medical School
hierarchy_parent_id swanseauniversitymedicalschool
hierarchy_parent_title Swansea University Medical School
department_str Medicine{{{_:::_}}}Swansea University Medical School{{{_:::_}}}Medicine
url http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090338
document_store_str 0
active_str 0
description As the development of siRNA therapeutics is technically challenging, this study evaluates various pre-clinical models in their ability to suitably test candidate siRNA for respiratory administration. This study shows that use of chemically-modified siRNA was not associated with cellular toxicity, yet enhanced bio-availability without evidence of reduced efficacy. Furthermore, we established a robust, sensitive method for determining siRNA bio-distribution in vivo, and co-developed a novel nasal administration model to further aid evaluation.
published_date 2014-02-28T03:31:22Z
_version_ 1674422657072758784
score 10.740733