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Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6

William Walker Orcid Logo, Gareth Healey Orcid Logo

PLoS ONE, Volume: 9, Issue: 2, Start page: e90338

Swansea University Authors: William Walker Orcid Logo, Gareth Healey Orcid Logo

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DOI (Published version): 10.1371/journal.pone.0090338

Abstract

As the development of siRNA therapeutics is technically challenging, this study evaluates various pre-clinical models in their ability to suitably test candidate siRNA for respiratory administration. This study shows that use of chemically-modified siRNA was not associated with cellular toxicity, ye...

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Published in: PLoS ONE
Published: 2014
Online Access: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090338
URI: https://cronfa.swan.ac.uk/Record/cronfa17428
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first_indexed 2014-03-05T02:30:03Z
last_indexed 2018-02-09T04:51:02Z
id cronfa17428
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spelling 2016-02-11T11:32:23.4702929 v2 17428 2014-03-04 Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6 1f736d4178747b6082940868d069894f 0000-0002-1940-5329 William Walker William Walker true false 5926519f89187489cfd5e1478aa188b1 0000-0001-9531-1220 Gareth Healey Gareth Healey true false 2014-03-04 BMS As the development of siRNA therapeutics is technically challenging, this study evaluates various pre-clinical models in their ability to suitably test candidate siRNA for respiratory administration. This study shows that use of chemically-modified siRNA was not associated with cellular toxicity, yet enhanced bio-availability without evidence of reduced efficacy. Furthermore, we established a robust, sensitive method for determining siRNA bio-distribution in vivo, and co-developed a novel nasal administration model to further aid evaluation. Journal Article PLoS ONE 9 2 e90338 28 2 2014 2014-02-28 10.1371/journal.pone.0090338 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090338 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2016-02-11T11:32:23.4702929 2014-03-04T10:33:03.1936660 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine William Walker 0000-0002-1940-5329 1 Gareth Healey 0000-0001-9531-1220 2
title Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6
spellingShingle Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6
William Walker
Gareth Healey
title_short Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6
title_full Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6
title_fullStr Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6
title_full_unstemmed Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6
title_sort Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6
author_id_str_mv 1f736d4178747b6082940868d069894f
5926519f89187489cfd5e1478aa188b1
author_id_fullname_str_mv 1f736d4178747b6082940868d069894f_***_William Walker
5926519f89187489cfd5e1478aa188b1_***_Gareth Healey
author William Walker
Gareth Healey
author2 William Walker
Gareth Healey
format Journal article
container_title PLoS ONE
container_volume 9
container_issue 2
container_start_page e90338
publishDate 2014
institution Swansea University
doi_str_mv 10.1371/journal.pone.0090338
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090338
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description As the development of siRNA therapeutics is technically challenging, this study evaluates various pre-clinical models in their ability to suitably test candidate siRNA for respiratory administration. This study shows that use of chemically-modified siRNA was not associated with cellular toxicity, yet enhanced bio-availability without evidence of reduced efficacy. Furthermore, we established a robust, sensitive method for determining siRNA bio-distribution in vivo, and co-developed a novel nasal administration model to further aid evaluation.
published_date 2014-02-28T03:20:06Z
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score 11.012678

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