Journal article 1264 views
Nucleophilic substitution of propargyl alcohols with aliphatic alcohols, aliphatic amines and heterocycles catalyzed by 4-nitrobenzenesulfonic acid: A scalable and metal-free process
S. Antony Savarimuthu,
D.G. Leo Prakash,
S. Augustine Thomas,
Leo Prakash 
Tetrahedron Letters
Swansea University Author:
Leo Prakash
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DOI (Published version): 10.1016/j.tetlet.2014.02.086
Abstract
It is aimed to provide a cost effective p-NBSA catalyzed nucleophilic substitution of propargyl alcohols with alcohols, amines and heterocycles, without employing corrosive and costly metal catalysts, toxic solvents and column chromatography for purification. A systematic study of C-C, C-N and C-O b...
| Published in: | Tetrahedron Letters |
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| Published: |
2014
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa17634 |
| Abstract: |
It is aimed to provide a cost effective p-NBSA catalyzed nucleophilic substitution of propargyl alcohols with alcohols, amines and heterocycles, without employing corrosive and costly metal catalysts, toxic solvents and column chromatography for purification. A systematic study of C-C, C-N and C-O bond formation and efficacy of the scalability have also been confirmed. |
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| Keywords: |
Propargyl alcohol; Propargyl ether; Propargyl amine; Heterocycles; Sulfonic acids |
| College: |
Faculty of Science and Engineering |