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Nucleophilic substitution of propargyl alcohols with aliphatic alcohols, aliphatic amines and heterocycles catalyzed by 4-nitrobenzenesulfonic acid: A scalable and metal-free process / S. Antony Savarimuthu, D.G. Leo Prakash, S. Augustine Thomas, Leo Prakash

Tetrahedron Letters

Swansea University Author: Leo Prakash

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DOI (Published version): 10.1016/j.tetlet.2014.02.086

Abstract

It is aimed to provide a cost effective p-NBSA catalyzed nucleophilic substitution of propargyl alcohols with alcohols, amines and heterocycles, without employing corrosive and costly metal catalysts, toxic solvents and column chromatography for purification. A systematic study of C-C, C-N and C-O b...

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Published in: Tetrahedron Letters
Published: 2014
URI: https://cronfa.swan.ac.uk/Record/cronfa17634
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Abstract: It is aimed to provide a cost effective p-NBSA catalyzed nucleophilic substitution of propargyl alcohols with alcohols, amines and heterocycles, without employing corrosive and costly metal catalysts, toxic solvents and column chromatography for purification. A systematic study of C-C, C-N and C-O bond formation and efficacy of the scalability have also been confirmed.
Keywords: Propargyl alcohol; Propargyl ether; Propargyl amine; Heterocycles; Sulfonic acids
College: College of Engineering