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Contributions of cellular and humoral immunity of Galleria mellonella larvae in defence against oral infection by Bacillus thuringiensis / Miranda, Walker (neeWhitten)

Journal of Invertebrate Pathology, Volume: 119, Pages: 40 - 46

Swansea University Author: Miranda, Walker (neeWhitten)

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DOI (Published version): 10.1016/j.jip.2014.04.003

Abstract

The Greater wax moth Galleria mellonella was used as a model organism to elucidate the underlying mechanisms of host-pathogen interactions following challenge by the bacterial bio-pesticide Bacillus thuringiensis. This bacterium is a vital tool in integrated pest management and it is thought that it...

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Published in: Journal of Invertebrate Pathology
Published: 2014
URI: https://cronfa.swan.ac.uk/Record/cronfa17945
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Abstract: The Greater wax moth Galleria mellonella was used as a model organism to elucidate the underlying mechanisms of host-pathogen interactions following challenge by the bacterial bio-pesticide Bacillus thuringiensis. This bacterium is a vital tool in integrated pest management and it is thought that it elicits insect killing via a combination of toxin production, dysbiosis and / or septicaemia. However, the nature of the immune & stress responses triggered in host insects has not yet been fully evaluated, nor has the nature of possible resistance or tolerance mechanisms. This paper addresses these issues, and proposes possible tolerance mechanisms that will help inform future biocontrol strategies.
Keywords: biocontrol, insect, Bacillus thuringiensis, immunology
College: Swansea University Medical School
Start Page: 40
End Page: 46