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Validation of Optimal Fourier Rheometry for rapidly gelling materials and its application in the study of collagen gelation / Daniel Curtis; A. Holder; N. Badiei; J. Claypole; M. Walters; B. Thomas; Matthew Barrow; Davide Deganello; Rowan Brown; Rhodri Williams; Karl Hawkins
Journal of Non-Newtonian Fluid Mechanics, Volume: 222, Pages: 253 - 259
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Rheological Gel Point measurements may incur errors in the case of rapid gelling systemsdue to the limitations of multiple frequency oscillatory shear techniques such as frequency sweeps and Fourier Transform Mechanical Spectroscopy, FTMS. These limitations are associated with sample mutation and da...
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Rheological Gel Point measurements may incur errors in the case of rapid gelling systemsdue to the limitations of multiple frequency oscillatory shear techniques such as frequency sweeps and Fourier Transform Mechanical Spectroscopy, FTMS. These limitations are associated with sample mutation and data interpolation. In the present paper we consider how an alternative rapid characterisation technique known as Optimal Fourier Rheometry, OFR, can be used to study a rapidly gelling material, namely collagen at near physiological temperatures. The OFR technique is validated using a model reference gelling system whose GP characteristics have been widely reported. An analysis of the susceptibility of OFR measurements to rheometrical artefacts is made prior to its use in study of rapid gelling collagen gels formed over a range of physiologically relevant collagen concentrations. The results of this OFR are the first measurements of the stress relaxation characteristics of collagen gels in a single rheological experiment.
2017 Reporting the first characterisation of complex biogel materials undergoing rapid rheological transitions using a technique known as Optimal Fourier Rheometry, this paper was presented at an international conference (British Society of Rheology, Durham) and initiated collaboration with UK (University of Glasgow, J. Rheology, DOI 10.1122/1.4953443) and international institutions (Faculty of Engineering, MIT). The technique is currently being exploited under the EPSRC Centre for Innovative Manufacturing in Large Area Electronics (EP/K03099X/1, £5.6M) and underpins an invited proposal (£5.4M) to the National Formulation Centre (CPI) supported by international industrial investment totalling £2.3M. IF = 2.172
Gel Point; Mutation Number; OFR; FTMS; Collagen.
College of Engineering