Journal article 1112 views
The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid
Steroids
Swansea University Authors:
Yuqin Wang , William Griffiths
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DOI (Published version): 10.1016/j.steroids.2015.02.021
Abstract
Oxysterols and cholestenoic acids are oxidised forms of cholesterol with a host of biological functions. The possible roles of oxysterols in various neurological diseases makes the analysis of these metabolites in the central nervous system of particular interest. Here, we report the identification...
Published in: | Steroids |
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2015
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URI: | https://cronfa.swan.ac.uk/Record/cronfa20335 |
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2015-12-21T09:58:02.5837644 v2 20335 2015-03-12 The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid c92729b58622f9fdf6a0e7d8f4ce5081 0000-0002-3063-3066 Yuqin Wang Yuqin Wang true false 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2015-03-12 BMS Oxysterols and cholestenoic acids are oxidised forms of cholesterol with a host of biological functions. The possible roles of oxysterols in various neurological diseases makes the analysis of these metabolites in the central nervous system of particular interest. Here, we report the identification and quantification of a panel of twelve sterols in mouse cerebrospinal fluid (CSF) using liquid chromatography - mass spectrometry exploiting enzyme assisted derivatisation for sterol analysis technology. We found low levels of oxysterols and cholestenoic acids in CSF the range of 5 pg/mL to 2.6 ng/mL. As found in man, these concentrations are one to two orders of magnitude lower than in plasma. Journal Article Steroids 31 12 2015 2015-12-31 10.1016/j.steroids.2015.02.021 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2015-12-21T09:58:02.5837644 2015-03-12T16:40:50.6709393 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Peter J. Crick 1 Lien Beckers 2 Myriam Baes 3 Paul P. Van Veldhoven 4 Yuqin Wang 0000-0002-3063-3066 5 William Griffiths 0000-0002-4129-6616 6 |
title |
The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid |
spellingShingle |
The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid Yuqin Wang William Griffiths |
title_short |
The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid |
title_full |
The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid |
title_fullStr |
The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid |
title_full_unstemmed |
The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid |
title_sort |
The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid |
author_id_str_mv |
c92729b58622f9fdf6a0e7d8f4ce5081 3316b1d1b524be1831790933eed1c26e |
author_id_fullname_str_mv |
c92729b58622f9fdf6a0e7d8f4ce5081_***_Yuqin Wang 3316b1d1b524be1831790933eed1c26e_***_William Griffiths |
author |
Yuqin Wang William Griffiths |
author2 |
Peter J. Crick Lien Beckers Myriam Baes Paul P. Van Veldhoven Yuqin Wang William Griffiths |
format |
Journal article |
container_title |
Steroids |
publishDate |
2015 |
institution |
Swansea University |
doi_str_mv |
10.1016/j.steroids.2015.02.021 |
college_str |
Faculty of Medicine, Health and Life Sciences |
hierarchytype |
|
hierarchy_top_id |
facultyofmedicinehealthandlifesciences |
hierarchy_top_title |
Faculty of Medicine, Health and Life Sciences |
hierarchy_parent_id |
facultyofmedicinehealthandlifesciences |
hierarchy_parent_title |
Faculty of Medicine, Health and Life Sciences |
department_str |
Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
document_store_str |
0 |
active_str |
0 |
description |
Oxysterols and cholestenoic acids are oxidised forms of cholesterol with a host of biological functions. The possible roles of oxysterols in various neurological diseases makes the analysis of these metabolites in the central nervous system of particular interest. Here, we report the identification and quantification of a panel of twelve sterols in mouse cerebrospinal fluid (CSF) using liquid chromatography - mass spectrometry exploiting enzyme assisted derivatisation for sterol analysis technology. We found low levels of oxysterols and cholestenoic acids in CSF the range of 5 pg/mL to 2.6 ng/mL. As found in man, these concentrations are one to two orders of magnitude lower than in plasma. |
published_date |
2015-12-31T03:23:59Z |
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1763750801269850112 |
score |
11.021648 |