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The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid

Peter J. Crick, Lien Beckers, Myriam Baes, Paul P. Van Veldhoven, Yuqin Wang Orcid Logo, William Griffiths Orcid Logo

Steroids

Swansea University Authors: Yuqin Wang Orcid Logo, William Griffiths Orcid Logo

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DOI (Published version): 10.1016/j.steroids.2015.02.021

Abstract

Oxysterols and cholestenoic acids are oxidised forms of cholesterol with a host of biological functions. The possible roles of oxysterols in various neurological diseases makes the analysis of these metabolites in the central nervous system of particular interest. Here, we report the identification...

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Published in: Steroids
Published: 2015
URI: https://cronfa.swan.ac.uk/Record/cronfa20335
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first_indexed 2015-03-17T03:03:23Z
last_indexed 2018-02-09T04:56:45Z
id cronfa20335
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spelling 2015-12-21T09:58:02.5837644 v2 20335 2015-03-12 The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid c92729b58622f9fdf6a0e7d8f4ce5081 0000-0002-3063-3066 Yuqin Wang Yuqin Wang true false 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false 2015-03-12 BMS Oxysterols and cholestenoic acids are oxidised forms of cholesterol with a host of biological functions. The possible roles of oxysterols in various neurological diseases makes the analysis of these metabolites in the central nervous system of particular interest. Here, we report the identification and quantification of a panel of twelve sterols in mouse cerebrospinal fluid (CSF) using liquid chromatography - mass spectrometry exploiting enzyme assisted derivatisation for sterol analysis technology. We found low levels of oxysterols and cholestenoic acids in CSF the range of 5 pg/mL to 2.6 ng/mL. As found in man, these concentrations are one to two orders of magnitude lower than in plasma. Journal Article Steroids 31 12 2015 2015-12-31 10.1016/j.steroids.2015.02.021 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2015-12-21T09:58:02.5837644 2015-03-12T16:40:50.6709393 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Peter J. Crick 1 Lien Beckers 2 Myriam Baes 3 Paul P. Van Veldhoven 4 Yuqin Wang 0000-0002-3063-3066 5 William Griffiths 0000-0002-4129-6616 6
title The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid
spellingShingle The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid
Yuqin Wang
William Griffiths
title_short The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid
title_full The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid
title_fullStr The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid
title_full_unstemmed The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid
title_sort The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid
author_id_str_mv c92729b58622f9fdf6a0e7d8f4ce5081
3316b1d1b524be1831790933eed1c26e
author_id_fullname_str_mv c92729b58622f9fdf6a0e7d8f4ce5081_***_Yuqin Wang
3316b1d1b524be1831790933eed1c26e_***_William Griffiths
author Yuqin Wang
William Griffiths
author2 Peter J. Crick
Lien Beckers
Myriam Baes
Paul P. Van Veldhoven
Yuqin Wang
William Griffiths
format Journal article
container_title Steroids
publishDate 2015
institution Swansea University
doi_str_mv 10.1016/j.steroids.2015.02.021
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
active_str 0
description Oxysterols and cholestenoic acids are oxidised forms of cholesterol with a host of biological functions. The possible roles of oxysterols in various neurological diseases makes the analysis of these metabolites in the central nervous system of particular interest. Here, we report the identification and quantification of a panel of twelve sterols in mouse cerebrospinal fluid (CSF) using liquid chromatography - mass spectrometry exploiting enzyme assisted derivatisation for sterol analysis technology. We found low levels of oxysterols and cholestenoic acids in CSF the range of 5 pg/mL to 2.6 ng/mL. As found in man, these concentrations are one to two orders of magnitude lower than in plasma.
published_date 2015-12-31T03:23:59Z
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score 11.030869

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