Journal article 541 views
Gene loss and lineage specific restriction-modification systems associated with niche differentiation in the Campylobacter jejuni Sequence Type 403 clonal complex.
Laura Morley,
Alan McNally,
Konrad Paszkiewicz,
Jukka Corander,
Guillaume Méric,
Samuel K. Sheppard,
Jochen Blom,
Georgina Manning,
Guillaume Meric
Applied and Environmental Microbiology, Start page: AEM.00546-15
Swansea University Author: Guillaume Meric
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DOI (Published version): 10.1128/AEM.00546-15
Abstract
Campylobacter jejuni is a highly diverse species of bacteria commonly associated with infectious intestinal disease of humans and zoonotic carriage in poultry, cattle, pigs, and other animals. The species contains a large number of distinct clonal complexes that vary from host generalist lineages co...
| Published in: | Applied and Environmental Microbiology |
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| Published: |
2015
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa20805 |
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| Abstract: |
Campylobacter jejuni is a highly diverse species of bacteria commonly associated with infectious intestinal disease of humans and zoonotic carriage in poultry, cattle, pigs, and other animals. The species contains a large number of distinct clonal complexes that vary from host generalist lineages commonly found in poultry livestock and human disease cases, to host-adapted specialised lineages primarily associated with livestock or poultry. Here we present novel data on the ST-403 clonal complex of C. jejuni, a lineage that has not been reported in avian hosts. Our data show this lineage exhibits a distinctive pattern of intra-lineage recombination that is accompanied by the presence of lineage specific restriction-modification systems. Furthermore we show that the ST-403 complex has undergone gene decay at a number of loci. Our data provides a putative link between the lack of association with avian hosts of C. jejuni ST403 and with both gene gain and gene loss through non-sense mutations in coding sequences of genes resulting in pseudogene formation. |
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| College: |
Faculty of Medicine, Health and Life Sciences |
| Start Page: |
AEM.00546-15 |