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Gene loss and lineage specific restriction-modification systems associated with niche differentiation in the Campylobacter jejuni Sequence Type 403 clonal complex.

Laura Morley, Alan McNally, Konrad Paszkiewicz, Jukka Corander, Guillaume Méric, Samuel K. Sheppard, Jochen Blom, Georgina Manning, Guillaume Meric

Applied and Environmental Microbiology, Start page: AEM.00546-15

Swansea University Author: Guillaume Meric

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DOI (Published version): 10.1128/AEM.00546-15

Abstract

Campylobacter jejuni is a highly diverse species of bacteria commonly associated with infectious intestinal disease of humans and zoonotic carriage in poultry, cattle, pigs, and other animals. The species contains a large number of distinct clonal complexes that vary from host generalist lineages co...

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Published in: Applied and Environmental Microbiology
Published: 2015
URI: https://cronfa.swan.ac.uk/Record/cronfa20805
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first_indexed 2015-04-21T02:07:34Z
last_indexed 2018-02-09T04:57:43Z
id cronfa20805
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spelling 2015-04-20T16:50:30.1264986 v2 20805 2015-04-20 Gene loss and lineage specific restriction-modification systems associated with niche differentiation in the Campylobacter jejuni Sequence Type 403 clonal complex. 9384e450ee619395be7459d6bd7a8f6d Guillaume Meric Guillaume Meric true false 2015-04-20 PMSC Campylobacter jejuni is a highly diverse species of bacteria commonly associated with infectious intestinal disease of humans and zoonotic carriage in poultry, cattle, pigs, and other animals. The species contains a large number of distinct clonal complexes that vary from host generalist lineages commonly found in poultry livestock and human disease cases, to host-adapted specialised lineages primarily associated with livestock or poultry. Here we present novel data on the ST-403 clonal complex of C. jejuni, a lineage that has not been reported in avian hosts. Our data show this lineage exhibits a distinctive pattern of intra-lineage recombination that is accompanied by the presence of lineage specific restriction-modification systems. Furthermore we show that the ST-403 complex has undergone gene decay at a number of loci. Our data provides a putative link between the lack of association with avian hosts of C. jejuni ST403 and with both gene gain and gene loss through non-sense mutations in coding sequences of genes resulting in pseudogene formation. Journal Article Applied and Environmental Microbiology AEM.00546-15 31 12 2015 2015-12-31 10.1128/AEM.00546-15 COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2015-04-20T16:50:30.1264986 2015-04-20T16:50:14.4800998 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Laura Morley 1 Alan McNally 2 Konrad Paszkiewicz 3 Jukka Corander 4 Guillaume Méric 5 Samuel K. Sheppard 6 Jochen Blom 7 Georgina Manning 8 Guillaume Meric 9
title Gene loss and lineage specific restriction-modification systems associated with niche differentiation in the Campylobacter jejuni Sequence Type 403 clonal complex.
spellingShingle Gene loss and lineage specific restriction-modification systems associated with niche differentiation in the Campylobacter jejuni Sequence Type 403 clonal complex.
Guillaume Meric
title_short Gene loss and lineage specific restriction-modification systems associated with niche differentiation in the Campylobacter jejuni Sequence Type 403 clonal complex.
title_full Gene loss and lineage specific restriction-modification systems associated with niche differentiation in the Campylobacter jejuni Sequence Type 403 clonal complex.
title_fullStr Gene loss and lineage specific restriction-modification systems associated with niche differentiation in the Campylobacter jejuni Sequence Type 403 clonal complex.
title_full_unstemmed Gene loss and lineage specific restriction-modification systems associated with niche differentiation in the Campylobacter jejuni Sequence Type 403 clonal complex.
title_sort Gene loss and lineage specific restriction-modification systems associated with niche differentiation in the Campylobacter jejuni Sequence Type 403 clonal complex.
author_id_str_mv 9384e450ee619395be7459d6bd7a8f6d
author_id_fullname_str_mv 9384e450ee619395be7459d6bd7a8f6d_***_Guillaume Meric
author Guillaume Meric
author2 Laura Morley
Alan McNally
Konrad Paszkiewicz
Jukka Corander
Guillaume Méric
Samuel K. Sheppard
Jochen Blom
Georgina Manning
Guillaume Meric
format Journal article
container_title Applied and Environmental Microbiology
container_start_page AEM.00546-15
publishDate 2015
institution Swansea University
doi_str_mv 10.1128/AEM.00546-15
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
active_str 0
description Campylobacter jejuni is a highly diverse species of bacteria commonly associated with infectious intestinal disease of humans and zoonotic carriage in poultry, cattle, pigs, and other animals. The species contains a large number of distinct clonal complexes that vary from host generalist lineages commonly found in poultry livestock and human disease cases, to host-adapted specialised lineages primarily associated with livestock or poultry. Here we present novel data on the ST-403 clonal complex of C. jejuni, a lineage that has not been reported in avian hosts. Our data show this lineage exhibits a distinctive pattern of intra-lineage recombination that is accompanied by the presence of lineage specific restriction-modification systems. Furthermore we show that the ST-403 complex has undergone gene decay at a number of loci. Our data provides a putative link between the lack of association with avian hosts of C. jejuni ST403 and with both gene gain and gene loss through non-sense mutations in coding sequences of genes resulting in pseudogene formation.
published_date 2015-12-31T03:24:38Z
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score 11.036553

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