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Aerobic Function and Muscle Deoxygenation Dynamics during Ramp Exercise in Children

Melitta McNarry Orcid Logo, COLIN FARR, ANDREW MIDDLEBROOKE, DEBORAH WELFORD, BRYNMOR BREESE, NEIL ARMSTRONG, ALAN R. BARKER

Medicine & Science in Sports & Exercise, Volume: 47, Issue: 9, Pages: 1877 - 1884

Swansea University Author: Melitta McNarry Orcid Logo

Abstract

PURPOSE:To characterise changes in deoxyhemoglobin ([HHb]) response dynamics in boys and girls during ramp incremental exercise to investigate whether the reduced peak oxygen uptake (peakV˙O2) in girls is associated with a poorer matching of muscle O2 delivery to muscle O2 utilisation, as evidenced...

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Published in: Medicine & Science in Sports & Exercise
ISSN: 0195-9131
Published: 2015
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URI: https://cronfa.swan.ac.uk/Record/cronfa21415
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2019-03-29T16:35:06.6542568</datestamp><bib-version>v2</bib-version><id>21415</id><entry>2015-05-14</entry><title>Aerobic Function and Muscle Deoxygenation Dynamics during Ramp Exercise in Children</title><swanseaauthors><author><sid>062f5697ff59f004bc8c713955988398</sid><ORCID>0000-0003-0813-7477</ORCID><firstname>Melitta</firstname><surname>McNarry</surname><name>Melitta McNarry</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2015-05-14</date><deptcode>STSC</deptcode><abstract>PURPOSE:To characterise changes in deoxyhemoglobin ([HHb]) response dynamics in boys and girls during ramp incremental exercise to investigate whether the reduced peak oxygen uptake (peakV&#x2D9;O2) in girls is associated with a poorer matching of muscle O2 delivery to muscle O2 utilisation, as evidenced by a more rapid increase in [HHb].METHODS:52 children (31 boys, 9.9 &#xB1; 0.6 years, 1.38 &#xB1; 0.07 m, 31.70 &#xB1; 5.78 kg) completed ramp incremental exercise on a cycle ergometer during which pulmonary gas exchange and muscle oxygenation parameters were measured.RESULTS:When muscle [HHb] was expressed against absolute work rate and V&#x2D9;O2, girls had an earlier change in [HHb] as evidenced by the lower c/d parameter (Girls: 54 &#xB1; 20 W vs Boys: 67 &#xB1; 19 W, P=0.023; Girls: 0.82 &#xB1; 0.28 L&#xB7;min vs. Boys: 0.95 &#xB1; 0.19 L&#xB7;min, P=0.055) and plateau (Girls: 85 &#xB1; 12 W vs. Boys: 99 &#xB1; 18 W, P=0.031; Girls: 1.02 &#xB1; 0.25 L&#xB7;min vs. Boys: 1.22 &#xB1; 0.28 L&#xB7;min, P=0.014). However, when expressed against relative work-rate or V&#x2D9;O2, there were no sex differences in [HHb] response dynamics (all P&amp;#62;0.20). Significant correlations were observed between absolute and fat-free mass normalised peak V&#x2D9;O2 and the HHb c/d and plateau parameters when expressed against absolute work-rate or V&#x2D9;O2. Furthermore, when entered into a multiple regression model, the [HHb] plateau against absolute V&#x2D9;O2 contributed 12% of the variance in peak V&#x2D9;O2 after adjusting for fat-free mass, gas exchange threshold, and body fatness (model R =0.81, P&amp;#60;0.001).CONCLUSION:The sex-difference in peak V&#x2D9;O2 in 9-10 year old children is, in part, related to sex-specific changes in muscle O2 extraction dynamics during incremental exercise.</abstract><type>Journal Article</type><journal>Medicine &amp; Science in Sports &amp; Exercise</journal><volume>47</volume><journalNumber>9</journalNumber><paginationStart>1877</paginationStart><paginationEnd>1884</paginationEnd><publisher/><issnPrint>0195-9131</issnPrint><keywords>NIRS; O2 delivery; O2 utilization; peak V&#xF026; O2; pre-pubertal; sex</keywords><publishedDay>30</publishedDay><publishedMonth>9</publishedMonth><publishedYear>2015</publishedYear><publishedDate>2015-09-30</publishedDate><doi>10.1249/MSS.0000000000000609</doi><url/><notes/><college>COLLEGE NANME</college><department>Sport and Exercise Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2019-03-29T16:35:06.6542568</lastEdited><Created>2015-05-14T18:43:08.6574816</Created><path><level id="1">College of Engineering</level><level id="2">Engineering</level></path><authors><author><firstname>Melitta</firstname><surname>McNarry</surname><orcid>0000-0003-0813-7477</orcid><order>1</order></author><author><firstname>COLIN</firstname><surname>FARR</surname><order>2</order></author><author><firstname>ANDREW</firstname><surname>MIDDLEBROOKE</surname><order>3</order></author><author><firstname>DEBORAH</firstname><surname>WELFORD</surname><order>4</order></author><author><firstname>BRYNMOR</firstname><surname>BREESE</surname><order>5</order></author><author><firstname>NEIL</firstname><surname>ARMSTRONG</surname><order>6</order></author><author><firstname>ALAN R.</firstname><surname>BARKER</surname><order>7</order></author></authors><documents><document><filename>0021415-14032016171904.pdf</filename><originalFilename>Finalv2.pdf</originalFilename><uploaded>2016-03-14T17:19:04.0600000</uploaded><type>Output</type><contentLength>299653</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2016-09-01T00:00:00.0000000</embargoDate><copyrightCorrect>false</copyrightCorrect></document></documents><OutputDurs/></rfc1807>
spelling 2019-03-29T16:35:06.6542568 v2 21415 2015-05-14 Aerobic Function and Muscle Deoxygenation Dynamics during Ramp Exercise in Children 062f5697ff59f004bc8c713955988398 0000-0003-0813-7477 Melitta McNarry Melitta McNarry true false 2015-05-14 STSC PURPOSE:To characterise changes in deoxyhemoglobin ([HHb]) response dynamics in boys and girls during ramp incremental exercise to investigate whether the reduced peak oxygen uptake (peakV˙O2) in girls is associated with a poorer matching of muscle O2 delivery to muscle O2 utilisation, as evidenced by a more rapid increase in [HHb].METHODS:52 children (31 boys, 9.9 ± 0.6 years, 1.38 ± 0.07 m, 31.70 ± 5.78 kg) completed ramp incremental exercise on a cycle ergometer during which pulmonary gas exchange and muscle oxygenation parameters were measured.RESULTS:When muscle [HHb] was expressed against absolute work rate and V˙O2, girls had an earlier change in [HHb] as evidenced by the lower c/d parameter (Girls: 54 ± 20 W vs Boys: 67 ± 19 W, P=0.023; Girls: 0.82 ± 0.28 L·min vs. Boys: 0.95 ± 0.19 L·min, P=0.055) and plateau (Girls: 85 ± 12 W vs. Boys: 99 ± 18 W, P=0.031; Girls: 1.02 ± 0.25 L·min vs. Boys: 1.22 ± 0.28 L·min, P=0.014). However, when expressed against relative work-rate or V˙O2, there were no sex differences in [HHb] response dynamics (all P&#62;0.20). Significant correlations were observed between absolute and fat-free mass normalised peak V˙O2 and the HHb c/d and plateau parameters when expressed against absolute work-rate or V˙O2. Furthermore, when entered into a multiple regression model, the [HHb] plateau against absolute V˙O2 contributed 12% of the variance in peak V˙O2 after adjusting for fat-free mass, gas exchange threshold, and body fatness (model R =0.81, P&#60;0.001).CONCLUSION:The sex-difference in peak V˙O2 in 9-10 year old children is, in part, related to sex-specific changes in muscle O2 extraction dynamics during incremental exercise. Journal Article Medicine & Science in Sports & Exercise 47 9 1877 1884 0195-9131 NIRS; O2 delivery; O2 utilization; peak V O2; pre-pubertal; sex 30 9 2015 2015-09-30 10.1249/MSS.0000000000000609 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2019-03-29T16:35:06.6542568 2015-05-14T18:43:08.6574816 College of Engineering Engineering Melitta McNarry 0000-0003-0813-7477 1 COLIN FARR 2 ANDREW MIDDLEBROOKE 3 DEBORAH WELFORD 4 BRYNMOR BREESE 5 NEIL ARMSTRONG 6 ALAN R. BARKER 7 0021415-14032016171904.pdf Finalv2.pdf 2016-03-14T17:19:04.0600000 Output 299653 application/pdf Accepted Manuscript true 2016-09-01T00:00:00.0000000 false
title Aerobic Function and Muscle Deoxygenation Dynamics during Ramp Exercise in Children
spellingShingle Aerobic Function and Muscle Deoxygenation Dynamics during Ramp Exercise in Children
Melitta McNarry
title_short Aerobic Function and Muscle Deoxygenation Dynamics during Ramp Exercise in Children
title_full Aerobic Function and Muscle Deoxygenation Dynamics during Ramp Exercise in Children
title_fullStr Aerobic Function and Muscle Deoxygenation Dynamics during Ramp Exercise in Children
title_full_unstemmed Aerobic Function and Muscle Deoxygenation Dynamics during Ramp Exercise in Children
title_sort Aerobic Function and Muscle Deoxygenation Dynamics during Ramp Exercise in Children
author_id_str_mv 062f5697ff59f004bc8c713955988398
author_id_fullname_str_mv 062f5697ff59f004bc8c713955988398_***_Melitta McNarry
author Melitta McNarry
author2 Melitta McNarry
COLIN FARR
ANDREW MIDDLEBROOKE
DEBORAH WELFORD
BRYNMOR BREESE
NEIL ARMSTRONG
ALAN R. BARKER
format Journal article
container_title Medicine & Science in Sports & Exercise
container_volume 47
container_issue 9
container_start_page 1877
publishDate 2015
institution Swansea University
issn 0195-9131
doi_str_mv 10.1249/MSS.0000000000000609
college_str College of Engineering
hierarchytype
hierarchy_top_id collegeofengineering
hierarchy_top_title College of Engineering
hierarchy_parent_id collegeofengineering
hierarchy_parent_title College of Engineering
department_str Engineering{{{_:::_}}}College of Engineering{{{_:::_}}}Engineering
document_store_str 1
active_str 0
description PURPOSE:To characterise changes in deoxyhemoglobin ([HHb]) response dynamics in boys and girls during ramp incremental exercise to investigate whether the reduced peak oxygen uptake (peakV˙O2) in girls is associated with a poorer matching of muscle O2 delivery to muscle O2 utilisation, as evidenced by a more rapid increase in [HHb].METHODS:52 children (31 boys, 9.9 ± 0.6 years, 1.38 ± 0.07 m, 31.70 ± 5.78 kg) completed ramp incremental exercise on a cycle ergometer during which pulmonary gas exchange and muscle oxygenation parameters were measured.RESULTS:When muscle [HHb] was expressed against absolute work rate and V˙O2, girls had an earlier change in [HHb] as evidenced by the lower c/d parameter (Girls: 54 ± 20 W vs Boys: 67 ± 19 W, P=0.023; Girls: 0.82 ± 0.28 L·min vs. Boys: 0.95 ± 0.19 L·min, P=0.055) and plateau (Girls: 85 ± 12 W vs. Boys: 99 ± 18 W, P=0.031; Girls: 1.02 ± 0.25 L·min vs. Boys: 1.22 ± 0.28 L·min, P=0.014). However, when expressed against relative work-rate or V˙O2, there were no sex differences in [HHb] response dynamics (all P&#62;0.20). Significant correlations were observed between absolute and fat-free mass normalised peak V˙O2 and the HHb c/d and plateau parameters when expressed against absolute work-rate or V˙O2. Furthermore, when entered into a multiple regression model, the [HHb] plateau against absolute V˙O2 contributed 12% of the variance in peak V˙O2 after adjusting for fat-free mass, gas exchange threshold, and body fatness (model R =0.81, P&#60;0.001).CONCLUSION:The sex-difference in peak V˙O2 in 9-10 year old children is, in part, related to sex-specific changes in muscle O2 extraction dynamics during incremental exercise.
published_date 2015-09-30T03:31:50Z
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