Journal article 889 views
The Feasibility of Using a Portable Xenon Delivery Device to Permit Earlier Xenon Ventilation with Therapeutic Cooling of Neonates During Ambulance Retrieval
John Dingley,
Xun Liu,
Hannah Gill,
Elisa Smit,
Hemmen Sabir,
James Tooley,
Ela Chakkarapani,
David Windsor,
Marianne Thoresen
Anesthesia & Analgesia, Volume: 120, Issue: 6, Pages: 1331 - 1336
Swansea University Author: John Dingley
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DOI (Published version): 10.1213/ANE.0000000000000693
Abstract
BACKGROUND:Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early.METHODS:During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval us...
| Published in: | Anesthesia & Analgesia |
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| ISSN: | 0003-2999 |
| Published: |
2015
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa27451 |
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| Abstract: |
BACKGROUND:Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early.METHODS:During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system.RESULTS:Without xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5-193.2) (median [interquartile range]), after circuit priming (1300 mL).CONCLUSIONS:Xenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.TRIAL REGISTRATION:ClinicalTrials.gov NCT01545271. |
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| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
6 |
| Start Page: |
1331 |
| End Page: |
1336 |