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The Feasibility of Using a Portable Xenon Delivery Device to Permit Earlier Xenon Ventilation with Therapeutic Cooling of Neonates During Ambulance Retrieval

John Dingley, Xun Liu, Hannah Gill, Elisa Smit, Hemmen Sabir, James Tooley, Ela Chakkarapani, David Windsor, Marianne Thoresen

Anesthesia & Analgesia, Volume: 120, Issue: 6, Pages: 1331 - 1336

Swansea University Author: John Dingley

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DOI (Published version): 10.1213/ANE.0000000000000693

Abstract

BACKGROUND:Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early.METHODS:During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval us...

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Published in: Anesthesia & Analgesia
ISSN: 0003-2999
Published: 2015
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URI: https://cronfa.swan.ac.uk/Record/cronfa27451
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first_indexed 2016-04-27T01:14:55Z
last_indexed 2018-06-30T04:06:31Z
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spelling 2018-06-29T19:35:39.9762146 v2 27451 2016-04-26 The Feasibility of Using a Portable Xenon Delivery Device to Permit Earlier Xenon Ventilation with Therapeutic Cooling of Neonates During Ambulance Retrieval 1283ffdd09b091ec57ec3e235a48cfcc John Dingley John Dingley true false 2016-04-26 PMSC BACKGROUND:Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early.METHODS:During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system.RESULTS:Without xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5-193.2) (median [interquartile range]), after circuit priming (1300 mL).CONCLUSIONS:Xenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.TRIAL REGISTRATION:ClinicalTrials.gov NCT01545271. Journal Article Anesthesia & Analgesia 120 6 1331 1336 0003-2999 31 12 2015 2015-12-31 10.1213/ANE.0000000000000693 COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2018-06-29T19:35:39.9762146 2016-04-26T22:23:24.2351503 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine John Dingley 1 Xun Liu 2 Hannah Gill 3 Elisa Smit 4 Hemmen Sabir 5 James Tooley 6 Ela Chakkarapani 7 David Windsor 8 Marianne Thoresen 9
title The Feasibility of Using a Portable Xenon Delivery Device to Permit Earlier Xenon Ventilation with Therapeutic Cooling of Neonates During Ambulance Retrieval
spellingShingle The Feasibility of Using a Portable Xenon Delivery Device to Permit Earlier Xenon Ventilation with Therapeutic Cooling of Neonates During Ambulance Retrieval
John Dingley
title_short The Feasibility of Using a Portable Xenon Delivery Device to Permit Earlier Xenon Ventilation with Therapeutic Cooling of Neonates During Ambulance Retrieval
title_full The Feasibility of Using a Portable Xenon Delivery Device to Permit Earlier Xenon Ventilation with Therapeutic Cooling of Neonates During Ambulance Retrieval
title_fullStr The Feasibility of Using a Portable Xenon Delivery Device to Permit Earlier Xenon Ventilation with Therapeutic Cooling of Neonates During Ambulance Retrieval
title_full_unstemmed The Feasibility of Using a Portable Xenon Delivery Device to Permit Earlier Xenon Ventilation with Therapeutic Cooling of Neonates During Ambulance Retrieval
title_sort The Feasibility of Using a Portable Xenon Delivery Device to Permit Earlier Xenon Ventilation with Therapeutic Cooling of Neonates During Ambulance Retrieval
author_id_str_mv 1283ffdd09b091ec57ec3e235a48cfcc
author_id_fullname_str_mv 1283ffdd09b091ec57ec3e235a48cfcc_***_John Dingley
author John Dingley
author2 John Dingley
Xun Liu
Hannah Gill
Elisa Smit
Hemmen Sabir
James Tooley
Ela Chakkarapani
David Windsor
Marianne Thoresen
format Journal article
container_title Anesthesia & Analgesia
container_volume 120
container_issue 6
container_start_page 1331
publishDate 2015
institution Swansea University
issn 0003-2999
doi_str_mv 10.1213/ANE.0000000000000693
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 0
active_str 0
description BACKGROUND:Therapeutic hypothermia is the standard of care after perinatal asphyxia. Preclinical studies show 50% xenon improves outcome, if started early.METHODS:During a 32-patient study randomized between hypothermia only and hypothermia with xenon, 5 neonates were given xenon during retrieval using a closed-circuit incubator-mounted system.RESULTS:Without xenon availability during retrieval, 50% of eligible infants exceeded the 5-hour treatment window. With the transportable system, 100% were recruited. Xenon delivery lasted 55 to 120 minutes, using 174 mL/h (117.5-193.2) (median [interquartile range]), after circuit priming (1300 mL).CONCLUSIONS:Xenon delivery during ambulance retrieval was feasible, reduced starting delays, and used very little gas.TRIAL REGISTRATION:ClinicalTrials.gov NCT01545271.
published_date 2015-12-31T03:33:17Z
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score 11.012678

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