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Systematic Review and Meta-Analysis: Infliximab or Cyclosporine as Rescue Therapy in Patients With Severe Ulcerative Colitis Refractory to Steroids

Neeraj Narula, John K Marshall, Jean-Frederic Colombel, Grigorios I Leontiadis, John Williams, Zack Muqtadir, Walter Reinisch

The American Journal of Gastroenterology, Volume: 111, Issue: 4, Pages: 477 - 491

Swansea University Author: John Williams

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DOI (Published version): 10.1038/ajg.2016.7

Abstract

Systematic review and meta-analysis of eight observational studies and three RCTs comparing infliximab and ciclosporin in the treatment of steroid resistant acute severe colitis. While non-randomised studies consistently favour infliximab, this is not supported by RCTs which show no difference betwe...

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Published in: The American Journal of Gastroenterology
Published: 2016
URI: https://cronfa.swan.ac.uk/Record/cronfa27782
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first_indexed 2016-05-10T15:56:49Z
last_indexed 2018-02-09T05:11:14Z
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spelling 2017-10-18T12:24:22.1702696 v2 27782 2016-05-10 Systematic Review and Meta-Analysis: Infliximab or Cyclosporine as Rescue Therapy in Patients With Severe Ulcerative Colitis Refractory to Steroids 911a5c03419acf47eab0844e2cd5ab7f John Williams John Williams true false 2016-05-10 SGMED Systematic review and meta-analysis of eight observational studies and three RCTs comparing infliximab and ciclosporin in the treatment of steroid resistant acute severe colitis. While non-randomised studies consistently favour infliximab, this is not supported by RCTs which show no difference between the two drugs in clinical outcomes. Journal Article The American Journal of Gastroenterology 111 4 477 491 9 2 2016 2016-02-09 10.1038/ajg.2016.7 COLLEGE NANME Medical School - School COLLEGE CODE SGMED Swansea University 2017-10-18T12:24:22.1702696 2016-05-10T10:03:28.9426639 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Neeraj Narula 1 John K Marshall 2 Jean-Frederic Colombel 3 Grigorios I Leontiadis 4 John Williams 5 Zack Muqtadir 6 Walter Reinisch 7
title Systematic Review and Meta-Analysis: Infliximab or Cyclosporine as Rescue Therapy in Patients With Severe Ulcerative Colitis Refractory to Steroids
spellingShingle Systematic Review and Meta-Analysis: Infliximab or Cyclosporine as Rescue Therapy in Patients With Severe Ulcerative Colitis Refractory to Steroids
John Williams
title_short Systematic Review and Meta-Analysis: Infliximab or Cyclosporine as Rescue Therapy in Patients With Severe Ulcerative Colitis Refractory to Steroids
title_full Systematic Review and Meta-Analysis: Infliximab or Cyclosporine as Rescue Therapy in Patients With Severe Ulcerative Colitis Refractory to Steroids
title_fullStr Systematic Review and Meta-Analysis: Infliximab or Cyclosporine as Rescue Therapy in Patients With Severe Ulcerative Colitis Refractory to Steroids
title_full_unstemmed Systematic Review and Meta-Analysis: Infliximab or Cyclosporine as Rescue Therapy in Patients With Severe Ulcerative Colitis Refractory to Steroids
title_sort Systematic Review and Meta-Analysis: Infliximab or Cyclosporine as Rescue Therapy in Patients With Severe Ulcerative Colitis Refractory to Steroids
author_id_str_mv 911a5c03419acf47eab0844e2cd5ab7f
author_id_fullname_str_mv 911a5c03419acf47eab0844e2cd5ab7f_***_John Williams
author John Williams
author2 Neeraj Narula
John K Marshall
Jean-Frederic Colombel
Grigorios I Leontiadis
John Williams
Zack Muqtadir
Walter Reinisch
format Journal article
container_title The American Journal of Gastroenterology
container_volume 111
container_issue 4
container_start_page 477
publishDate 2016
institution Swansea University
doi_str_mv 10.1038/ajg.2016.7
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
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description Systematic review and meta-analysis of eight observational studies and three RCTs comparing infliximab and ciclosporin in the treatment of steroid resistant acute severe colitis. While non-randomised studies consistently favour infliximab, this is not supported by RCTs which show no difference between the two drugs in clinical outcomes.
published_date 2016-02-09T03:33:45Z
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