No Cover Image

Journal article 612 views 97 downloads

Complement is activated in progressive multiple sclerosis cortical grey matter lesions / Lewis Watkins; James W. Neal; Sam Loveless; Iliana Michailidou; Valeria Ramaglia; Mark Rees; Richard Reynolds; Neil P. Robertson; B. Paul Morgan; Owain Howell

Journal of Neuroinflammation, Volume: 13, Issue: 1

Swansea University Authors: Lewis, Watkins, Mark, Rees, Owain, Howell

  • Complementisactivated.pdf

    PDF | Version of Record

    Released under the terms of a Creative Commons Attribution 4.0 International License (CC-BY).

    Download (2.36MB)

Abstract

The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing neurological disability in progressive MS. Determining...

Full description

Published in: Journal of Neuroinflammation
ISSN: 1742-2094
Published: Springer Science and Business Media LLC 2016
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa29210
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing neurological disability in progressive MS. Determining pathological mechanisms at play in MS grey matter is therefore a key to our understanding of disease progression.
Keywords: Complemen; Grey matter lesion; Innate immunity; Multiple sclerosis; Neurodegeneration
College: Swansea University Medical School
Issue: 1