Complement is activated in progressive multiple sclerosis cortical grey matter lesions

Watkins, Lewis; Neal, James W.; Loveless, Sam; Michailidou, Iliana; Ramaglia, Valeria; Rees, Mark; Reynolds, Richard; Robertson, Neil P.; Morgan, B. Paul; Howell, Owain

doi:10.1186/s12974-016-0611-x

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Complement is activated in progressive multiple sclerosis cortical grey matter lesions

Lewis Watkins, James W. Neal, Sam Loveless, Iliana Michailidou, Valeria Ramaglia, Mark Rees, Richard Reynolds, Neil P. Robertson, B. Paul Morgan, Owain Howell

Journal of Neuroinflammation, Volume: 13, Issue: 1

Swansea University Authors: Lewis Watkins, Mark Rees, Owain Howell

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DOI (Published version): 10.1186/s12974-016-0611-x

Abstract

The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing neurological disability in progressive MS. Determining...

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Published in:	Journal of Neuroinflammation
ISSN:	1742-2094
Published:	Springer Science and Business Media LLC 2016
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa29210
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first_indexed	2016-07-13T18:17:31Z
last_indexed	2020-08-03T12:45:41Z
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spelling	2020-08-03T11:46:26.5735794 v2 29210 2016-07-13 Complement is activated in progressive multiple sclerosis cortical grey matter lesions 255b8c16eb0ed44b6a3f85f584916bc3 Lewis Watkins Lewis Watkins true false 10f39a4e9c2ee00d453cd84c10667ac8 Mark Rees Mark Rees true false 58c995486fc93a242b987640b692db8c 0000-0003-2157-9157 Owain Howell Owain Howell true false 2016-07-13 PMSC The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing neurological disability in progressive MS. Determining pathological mechanisms at play in MS grey matter is therefore a key to our understanding of disease progression. Journal Article Journal of Neuroinflammation 13 1 Springer Science and Business Media LLC 1742-2094 Complemen; Grey matter lesion; Innate immunity; Multiple sclerosis; Neurodegeneration 1 12 2016 2016-12-01 10.1186/s12974-016-0611-x COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University own funds 2020-08-03T11:46:26.5735794 2016-07-13T14:15:21.0177249 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Lewis Watkins 1 James W. Neal 2 Sam Loveless 3 Iliana Michailidou 4 Valeria Ramaglia 5 Mark Rees 6 Richard Reynolds 7 Neil P. Robertson 8 B. Paul Morgan 9 Owain Howell 0000-0003-2157-9157 10 0029210-16092016151639.pdf Complementisactivated.pdf 2016-09-16T15:16:39.2800000 Output 2551353 application/pdf Version of Record true Released under the terms of a Creative Commons Attribution 4.0 International License (CC-BY). true eng http://creativecommons.org/licenses/by/4.0/
title	Complement is activated in progressive multiple sclerosis cortical grey matter lesions
spellingShingle	Complement is activated in progressive multiple sclerosis cortical grey matter lesions Lewis Watkins Mark Rees Owain Howell
title_short	Complement is activated in progressive multiple sclerosis cortical grey matter lesions
title_full	Complement is activated in progressive multiple sclerosis cortical grey matter lesions
title_fullStr	Complement is activated in progressive multiple sclerosis cortical grey matter lesions
title_full_unstemmed	Complement is activated in progressive multiple sclerosis cortical grey matter lesions
title_sort	Complement is activated in progressive multiple sclerosis cortical grey matter lesions
author_id_str_mv	255b8c16eb0ed44b6a3f85f584916bc3 10f39a4e9c2ee00d453cd84c10667ac8 58c995486fc93a242b987640b692db8c
author_id_fullname_str_mv	255b8c16eb0ed44b6a3f85f584916bc3_*_Lewis Watkins 10f39a4e9c2ee00d453cd84c10667ac8__Mark Rees 58c995486fc93a242b987640b692db8c_**_Owain Howell
author	Lewis Watkins Mark Rees Owain Howell
author2	Lewis Watkins James W. Neal Sam Loveless Iliana Michailidou Valeria Ramaglia Mark Rees Richard Reynolds Neil P. Robertson B. Paul Morgan Owain Howell
format	Journal article
container_title	Journal of Neuroinflammation
container_volume	13
container_issue	1
publishDate	2016
institution	Swansea University
issn	1742-2094
doi_str_mv	10.1186/s12974-016-0611-x
publisher	Springer Science and Business Media LLC
college_str	Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str	1
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description	The symptoms of multiple sclerosis (MS) are caused by damage to myelin and nerve cells in the brain and spinal cord. Inflammation is tightly linked with neurodegeneration, and it is the accumulation of neurodegeneration that underlies increasing neurological disability in progressive MS. Determining pathological mechanisms at play in MS grey matter is therefore a key to our understanding of disease progression.
published_date	2016-12-01T03:35:36Z
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score	11.016235

Complement is activated in progressive multiple sclerosis cortical grey matter lesions

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