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Translucent and ductile nanocellulose-PEG bionanocomposites—A novel substrate with potential to be functionalized by printing for wound dressing applications

Zari Tehrani Orcid Logo, Henriette Rogstad Nordli, Brita Pukstad, David Gethin Orcid Logo, Gary Chinga-Carrasco

Industrial Crops and Products, Volume: 93, Pages: 193 - 202

Swansea University Authors: Zari Tehrani Orcid Logo, David Gethin Orcid Logo

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DOI (Published version): 10.1016/j.indcrop.2016.02.024

Abstract

There is potential that nanocellulose structures can act as a substrate for biomedical applications in which printing can expand its use as a functionalized biomaterial. Nanocellulose has a variety of advantages, which make the material suitable for use in biomedical devices that include wound dress...

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Published in: Industrial Crops and Products
ISSN: 0926-6690
Published: 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa30248
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first_indexed 2016-09-28T19:01:14Z
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spelling 2023-02-02T16:04:00.8566810 v2 30248 2016-09-28 Translucent and ductile nanocellulose-PEG bionanocomposites—A novel substrate with potential to be functionalized by printing for wound dressing applications fd8e614b01086804c80fbafa6fa6aaf5 0000-0002-5069-7921 Zari Tehrani Zari Tehrani true false 20b93675a5457203ae87ebc32bd6d155 0000-0002-7142-8253 David Gethin David Gethin true false 2016-09-28 CHEG There is potential that nanocellulose structures can act as a substrate for biomedical applications in which printing can expand its use as a functionalized biomaterial. Nanocellulose has a variety of advantages, which make the material suitable for use in biomedical devices that include wound dressings. The material does not promote bacterial growth, allows for production of translucent films and provides a moist wound-healing environment. However it is intrinsically brittle so research is needed to develop its flexibility and strength through the addition of plasticisers. In this work, we explore the effect of Polyethylene Glycol (PEG 400) as a plasticizer on nanocellulose film formation and performance. The nanocellulose used was prepared with TEMPO mediated oxidation. We also demonstrated different methods such as laser profilometry and atomic force microscopy to observe the topography and morphology of the films. FTIR, UV–vis spectroscopy was used to look at the characteristics of the nanocellulose films. In addition, the mechanical strength of the films with and without plasticizers was assessed. This led to the formulation of films that included PEG400 at 10–40% by weight. These demonstrated properties that are suitable for wound dressings. Additionally, the PEG modification yielded films that showed a surface morphology adequate for surface modification by printing. Importantly, a cytotoxicity test was performed using Human Dermal Fibroblasts and Human Epidermal Keratinocytes. The results showed no effect on the metabolic activity when fibroblasts were incubated in the presence of films containing 10 and 25% PEG. A reduction was measured in the presence of PEG at 40%. However, no significant cell death was detected in any of the cell-types. Hence, the nanocellulose-PEG films are not considered to be cytotoxic against human skin cells at the concentrations applied in this study. Journal Article Industrial Crops and Products 93 193 202 0926-6690 CNF; Nanocellulose; Bionanocomposites; Printing; Plasticizer 25 12 2016 2016-12-25 10.1016/j.indcrop.2016.02.024 COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University 2023-02-02T16:04:00.8566810 2016-09-28T13:31:56.2682372 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering Zari Tehrani 0000-0002-5069-7921 1 Henriette Rogstad Nordli 2 Brita Pukstad 3 David Gethin 0000-0002-7142-8253 4 Gary Chinga-Carrasco 5
title Translucent and ductile nanocellulose-PEG bionanocomposites—A novel substrate with potential to be functionalized by printing for wound dressing applications
spellingShingle Translucent and ductile nanocellulose-PEG bionanocomposites—A novel substrate with potential to be functionalized by printing for wound dressing applications
Zari Tehrani
David Gethin
title_short Translucent and ductile nanocellulose-PEG bionanocomposites—A novel substrate with potential to be functionalized by printing for wound dressing applications
title_full Translucent and ductile nanocellulose-PEG bionanocomposites—A novel substrate with potential to be functionalized by printing for wound dressing applications
title_fullStr Translucent and ductile nanocellulose-PEG bionanocomposites—A novel substrate with potential to be functionalized by printing for wound dressing applications
title_full_unstemmed Translucent and ductile nanocellulose-PEG bionanocomposites—A novel substrate with potential to be functionalized by printing for wound dressing applications
title_sort Translucent and ductile nanocellulose-PEG bionanocomposites—A novel substrate with potential to be functionalized by printing for wound dressing applications
author_id_str_mv fd8e614b01086804c80fbafa6fa6aaf5
20b93675a5457203ae87ebc32bd6d155
author_id_fullname_str_mv fd8e614b01086804c80fbafa6fa6aaf5_***_Zari Tehrani
20b93675a5457203ae87ebc32bd6d155_***_David Gethin
author Zari Tehrani
David Gethin
author2 Zari Tehrani
Henriette Rogstad Nordli
Brita Pukstad
David Gethin
Gary Chinga-Carrasco
format Journal article
container_title Industrial Crops and Products
container_volume 93
container_start_page 193
publishDate 2016
institution Swansea University
issn 0926-6690
doi_str_mv 10.1016/j.indcrop.2016.02.024
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Mechanical Engineering
document_store_str 0
active_str 0
description There is potential that nanocellulose structures can act as a substrate for biomedical applications in which printing can expand its use as a functionalized biomaterial. Nanocellulose has a variety of advantages, which make the material suitable for use in biomedical devices that include wound dressings. The material does not promote bacterial growth, allows for production of translucent films and provides a moist wound-healing environment. However it is intrinsically brittle so research is needed to develop its flexibility and strength through the addition of plasticisers. In this work, we explore the effect of Polyethylene Glycol (PEG 400) as a plasticizer on nanocellulose film formation and performance. The nanocellulose used was prepared with TEMPO mediated oxidation. We also demonstrated different methods such as laser profilometry and atomic force microscopy to observe the topography and morphology of the films. FTIR, UV–vis spectroscopy was used to look at the characteristics of the nanocellulose films. In addition, the mechanical strength of the films with and without plasticizers was assessed. This led to the formulation of films that included PEG400 at 10–40% by weight. These demonstrated properties that are suitable for wound dressings. Additionally, the PEG modification yielded films that showed a surface morphology adequate for surface modification by printing. Importantly, a cytotoxicity test was performed using Human Dermal Fibroblasts and Human Epidermal Keratinocytes. The results showed no effect on the metabolic activity when fibroblasts were incubated in the presence of films containing 10 and 25% PEG. A reduction was measured in the presence of PEG at 40%. However, no significant cell death was detected in any of the cell-types. Hence, the nanocellulose-PEG films are not considered to be cytotoxic against human skin cells at the concentrations applied in this study.
published_date 2016-12-25T03:36:53Z
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