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Integration of Silicon and Printed Electronics for Rapid Diagnostic Disease Biosensing

Daniel J. Thomas, Zari Tehrani Orcid Logo

Point of Care: The Journal of Near-Patient Testing & Technology, Volume: 15, Issue: 2, Pages: 61 - 71

Swansea University Author: Zari Tehrani Orcid Logo

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DOI (Published version): 10.1097/POC.0000000000000091

Abstract

During this research, we developed a printed point-of-care device that was integrated with a biosensing silicon sensor. This resulted in the detection of a specific biomarker, which indicates the presence of a series of common diseases. The selective detection of biomarkers is an important component...

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Published in: Point of Care: The Journal of Near-Patient Testing & Technology
ISSN: 1533-029X
Published: 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa31388
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first_indexed 2016-12-08T15:06:18Z
last_indexed 2018-02-09T05:18:14Z
id cronfa31388
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spelling 2017-02-03T12:33:25.8497864 v2 31388 2016-12-08 Integration of Silicon and Printed Electronics for Rapid Diagnostic Disease Biosensing fd8e614b01086804c80fbafa6fa6aaf5 0000-0002-5069-7921 Zari Tehrani Zari Tehrani true false 2016-12-08 CHEG During this research, we developed a printed point-of-care device that was integrated with a biosensing silicon sensor. This resulted in the detection of a specific biomarker, which indicates the presence of a series of common diseases. The selective detection of biomarkers is an important component for early diagnosis. We fabricated an integrated device, which has inbuilt 200-[mu]m-wide carbon printed electrical connections to a biosensor. This was found to be an essential component of making a noninvasive device. The present work describes the use of 3-dimensional printing fabrication techniques for producing a prototype point-of-care system made from aliphatic polyurethane polymer. During this research, the biosensor was selectively functionalized with antibodies. These results prove the concept of the specific and selective attachment of bioreceptor antibodies, which can subsequently be used for the detection of particular target biomolecules. The integration of carbon printed electronics as a critical component in the detection of disease provides a promising new route to rapid bioanalysis diagnosis. Journal Article Point of Care: The Journal of Near-Patient Testing & Technology 15 2 61 71 1533-029X 30 6 2016 2016-06-30 10.1097/POC.0000000000000091 COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University 2017-02-03T12:33:25.8497864 2016-12-08T10:49:39.4405335 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Daniel J. Thomas 1 Zari Tehrani 0000-0002-5069-7921 2
title Integration of Silicon and Printed Electronics for Rapid Diagnostic Disease Biosensing
spellingShingle Integration of Silicon and Printed Electronics for Rapid Diagnostic Disease Biosensing
Zari Tehrani
title_short Integration of Silicon and Printed Electronics for Rapid Diagnostic Disease Biosensing
title_full Integration of Silicon and Printed Electronics for Rapid Diagnostic Disease Biosensing
title_fullStr Integration of Silicon and Printed Electronics for Rapid Diagnostic Disease Biosensing
title_full_unstemmed Integration of Silicon and Printed Electronics for Rapid Diagnostic Disease Biosensing
title_sort Integration of Silicon and Printed Electronics for Rapid Diagnostic Disease Biosensing
author_id_str_mv fd8e614b01086804c80fbafa6fa6aaf5
author_id_fullname_str_mv fd8e614b01086804c80fbafa6fa6aaf5_***_Zari Tehrani
author Zari Tehrani
author2 Daniel J. Thomas
Zari Tehrani
format Journal article
container_title Point of Care: The Journal of Near-Patient Testing & Technology
container_volume 15
container_issue 2
container_start_page 61
publishDate 2016
institution Swansea University
issn 1533-029X
doi_str_mv 10.1097/POC.0000000000000091
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
document_store_str 0
active_str 0
description During this research, we developed a printed point-of-care device that was integrated with a biosensing silicon sensor. This resulted in the detection of a specific biomarker, which indicates the presence of a series of common diseases. The selective detection of biomarkers is an important component for early diagnosis. We fabricated an integrated device, which has inbuilt 200-[mu]m-wide carbon printed electrical connections to a biosensor. This was found to be an essential component of making a noninvasive device. The present work describes the use of 3-dimensional printing fabrication techniques for producing a prototype point-of-care system made from aliphatic polyurethane polymer. During this research, the biosensor was selectively functionalized with antibodies. These results prove the concept of the specific and selective attachment of bioreceptor antibodies, which can subsequently be used for the detection of particular target biomolecules. The integration of carbon printed electronics as a critical component in the detection of disease provides a promising new route to rapid bioanalysis diagnosis.
published_date 2016-06-30T03:38:21Z
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score 11.036706

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