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Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker / Daniel J. Thomas; Mohd Azraie Mohd Azmi; Zari Tehrani

Point of Care: The Journal of Near-Patient Testing & Technology, Volume: 13, Issue: 2, Pages: 54 - 65

Swansea University Author: Zari, Tehrani

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Abstract

Nanowire-based detection strategies provide promising new routes to rapid bioanalysis and detection of disease. These systems have a high degree of potential toward making developments in the diagnosis of disease. The fabrication of active flow microchannels is an essential component of these future...

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Published in: Point of Care: The Journal of Near-Patient Testing & Technology
ISSN: 1533-029X
Published: 2014
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa31396
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Abstract: Nanowire-based detection strategies provide promising new routes to rapid bioanalysis and detection of disease. These systems have a high degree of potential toward making developments in the diagnosis of disease. The fabrication of active flow microchannels is an essential component of these future noninvasive devices. The present work describes the use of 3-dimensional (3D) printing fabrication techniques for producing a prototype point-of-care system with integrated biochip and active flow microchannels. This microchannel-based device is made from polylactic acid polymer. The reported 3D printed process allowed the fabrication of 400-[mu]m width micochannels, which was integrated with a functionalized silicon nanowire biochip. This technique enabled the production of a combined immunobiosensor with inbuilt flexoprinted contacts. During this research, the biochip was biologically functionalized with antibodies of 8-hydroxydeoxyguanosine (8-OHdG), which is a biomarker linked to several common cancers. The present work describes a fabrication technique for building and testing a 3D printed microchannel-based device that was used to detect 8-OHdG antibodies.
College: College of Engineering
Issue: 2
Start Page: 54
End Page: 65