Journal article 3350 views
Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker
Point of Care: The Journal of Near-Patient Testing & Technology, Volume: 13, Issue: 2, Pages: 54 - 65
Swansea University Author:
Zari Tehrani
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DOI (Published version): 10.1097/POC.0000000000000011
Abstract
Nanowire-based detection strategies provide promising new routes to rapid bioanalysis and detection of disease. These systems have a high degree of potential toward making developments in the diagnosis of disease. The fabrication of active flow microchannels is an essential component of these future...
| Published in: | Point of Care: The Journal of Near-Patient Testing & Technology |
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| ISSN: | 1533-029X |
| Published: |
2014
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa31396 |
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| Abstract: |
Nanowire-based detection strategies provide promising new routes to rapid bioanalysis and detection of disease. These systems have a high degree of potential toward making developments in the diagnosis of disease. The fabrication of active flow microchannels is an essential component of these future noninvasive devices. The present work describes the use of 3-dimensional (3D) printing fabrication techniques for producing a prototype point-of-care system with integrated biochip and active flow microchannels. This microchannel-based device is made from polylactic acid polymer. The reported 3D printed process allowed the fabrication of 400-[mu]m width micochannels, which was integrated with a functionalized silicon nanowire biochip. This technique enabled the production of a combined immunobiosensor with inbuilt flexoprinted contacts. During this research, the biochip was biologically functionalized with antibodies of 8-hydroxydeoxyguanosine (8-OHdG), which is a biomarker linked to several common cancers. The present work describes a fabrication technique for building and testing a 3D printed microchannel-based device that was used to detect 8-OHdG antibodies. |
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| College: |
Faculty of Science and Engineering |
| Issue: |
2 |
| Start Page: |
54 |
| End Page: |
65 |