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Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker

Daniel J. Thomas, Mohd Azraie Mohd Azmi, Zari Tehrani Orcid Logo

Point of Care: The Journal of Near-Patient Testing & Technology, Volume: 13, Issue: 2, Pages: 54 - 65

Swansea University Author: Zari Tehrani Orcid Logo

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DOI (Published version): 10.1097/POC.0000000000000011

Abstract

Nanowire-based detection strategies provide promising new routes to rapid bioanalysis and detection of disease. These systems have a high degree of potential toward making developments in the diagnosis of disease. The fabrication of active flow microchannels is an essential component of these future...

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Published in: Point of Care: The Journal of Near-Patient Testing & Technology
ISSN: 1533-029X
Published: 2014
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URI: https://cronfa.swan.ac.uk/Record/cronfa31396
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first_indexed 2016-12-08T15:06:21Z
last_indexed 2018-02-09T05:18:16Z
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spelling 2016-12-08T11:25:25.3059876 v2 31396 2016-12-08 Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker fd8e614b01086804c80fbafa6fa6aaf5 0000-0002-5069-7921 Zari Tehrani Zari Tehrani true false 2016-12-08 CHEG Nanowire-based detection strategies provide promising new routes to rapid bioanalysis and detection of disease. These systems have a high degree of potential toward making developments in the diagnosis of disease. The fabrication of active flow microchannels is an essential component of these future noninvasive devices. The present work describes the use of 3-dimensional (3D) printing fabrication techniques for producing a prototype point-of-care system with integrated biochip and active flow microchannels. This microchannel-based device is made from polylactic acid polymer. The reported 3D printed process allowed the fabrication of 400-[mu]m width micochannels, which was integrated with a functionalized silicon nanowire biochip. This technique enabled the production of a combined immunobiosensor with inbuilt flexoprinted contacts. During this research, the biochip was biologically functionalized with antibodies of 8-hydroxydeoxyguanosine (8-OHdG), which is a biomarker linked to several common cancers. The present work describes a fabrication technique for building and testing a 3D printed microchannel-based device that was used to detect 8-OHdG antibodies. Journal Article Point of Care: The Journal of Near-Patient Testing & Technology 13 2 54 65 1533-029X 30 6 2014 2014-06-30 10.1097/POC.0000000000000011 COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University 2016-12-08T11:25:25.3059876 2016-12-08T11:24:15.6980500 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Daniel J. Thomas 1 Mohd Azraie Mohd Azmi 2 Zari Tehrani 0000-0002-5069-7921 3
title Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker
spellingShingle Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker
Zari Tehrani
title_short Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker
title_full Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker
title_fullStr Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker
title_full_unstemmed Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker
title_sort Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker
author_id_str_mv fd8e614b01086804c80fbafa6fa6aaf5
author_id_fullname_str_mv fd8e614b01086804c80fbafa6fa6aaf5_***_Zari Tehrani
author Zari Tehrani
author2 Daniel J. Thomas
Mohd Azraie Mohd Azmi
Zari Tehrani
format Journal article
container_title Point of Care: The Journal of Near-Patient Testing & Technology
container_volume 13
container_issue 2
container_start_page 54
publishDate 2014
institution Swansea University
issn 1533-029X
doi_str_mv 10.1097/POC.0000000000000011
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
document_store_str 0
active_str 0
description Nanowire-based detection strategies provide promising new routes to rapid bioanalysis and detection of disease. These systems have a high degree of potential toward making developments in the diagnosis of disease. The fabrication of active flow microchannels is an essential component of these future noninvasive devices. The present work describes the use of 3-dimensional (3D) printing fabrication techniques for producing a prototype point-of-care system with integrated biochip and active flow microchannels. This microchannel-based device is made from polylactic acid polymer. The reported 3D printed process allowed the fabrication of 400-[mu]m width micochannels, which was integrated with a functionalized silicon nanowire biochip. This technique enabled the production of a combined immunobiosensor with inbuilt flexoprinted contacts. During this research, the biochip was biologically functionalized with antibodies of 8-hydroxydeoxyguanosine (8-OHdG), which is a biomarker linked to several common cancers. The present work describes a fabrication technique for building and testing a 3D printed microchannel-based device that was used to detect 8-OHdG antibodies.
published_date 2014-06-30T03:38:21Z
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score 11.012678

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