Journal article 3317 views
Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker
Point of Care: The Journal of Near-Patient Testing & Technology, Volume: 13, Issue: 2, Pages: 54 - 65
Swansea University Author: Zari Tehrani
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DOI (Published version): 10.1097/POC.0000000000000011
Abstract
Nanowire-based detection strategies provide promising new routes to rapid bioanalysis and detection of disease. These systems have a high degree of potential toward making developments in the diagnosis of disease. The fabrication of active flow microchannels is an essential component of these future...
Published in: | Point of Care: The Journal of Near-Patient Testing & Technology |
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ISSN: | 1533-029X |
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2014
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URI: | https://cronfa.swan.ac.uk/Record/cronfa31396 |
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2016-12-08T11:25:25.3059876 v2 31396 2016-12-08 Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker fd8e614b01086804c80fbafa6fa6aaf5 0000-0002-5069-7921 Zari Tehrani Zari Tehrani true false 2016-12-08 CHEG Nanowire-based detection strategies provide promising new routes to rapid bioanalysis and detection of disease. These systems have a high degree of potential toward making developments in the diagnosis of disease. The fabrication of active flow microchannels is an essential component of these future noninvasive devices. The present work describes the use of 3-dimensional (3D) printing fabrication techniques for producing a prototype point-of-care system with integrated biochip and active flow microchannels. This microchannel-based device is made from polylactic acid polymer. The reported 3D printed process allowed the fabrication of 400-[mu]m width micochannels, which was integrated with a functionalized silicon nanowire biochip. This technique enabled the production of a combined immunobiosensor with inbuilt flexoprinted contacts. During this research, the biochip was biologically functionalized with antibodies of 8-hydroxydeoxyguanosine (8-OHdG), which is a biomarker linked to several common cancers. The present work describes a fabrication technique for building and testing a 3D printed microchannel-based device that was used to detect 8-OHdG antibodies. Journal Article Point of Care: The Journal of Near-Patient Testing & Technology 13 2 54 65 1533-029X 30 6 2014 2014-06-30 10.1097/POC.0000000000000011 COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University 2016-12-08T11:25:25.3059876 2016-12-08T11:24:15.6980500 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Daniel J. Thomas 1 Mohd Azraie Mohd Azmi 2 Zari Tehrani 0000-0002-5069-7921 3 |
title |
Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker |
spellingShingle |
Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker Zari Tehrani |
title_short |
Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker |
title_full |
Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker |
title_fullStr |
Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker |
title_full_unstemmed |
Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker |
title_sort |
Fabrication of an Integrated 3-Dimensional Printed Polymer Silicon Nanowire–Based Microfluidic Point-of-Care System for Detecting 8-OHdG Cancer Biomarker |
author_id_str_mv |
fd8e614b01086804c80fbafa6fa6aaf5 |
author_id_fullname_str_mv |
fd8e614b01086804c80fbafa6fa6aaf5_***_Zari Tehrani |
author |
Zari Tehrani |
author2 |
Daniel J. Thomas Mohd Azraie Mohd Azmi Zari Tehrani |
format |
Journal article |
container_title |
Point of Care: The Journal of Near-Patient Testing & Technology |
container_volume |
13 |
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54 |
publishDate |
2014 |
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Swansea University |
issn |
1533-029X |
doi_str_mv |
10.1097/POC.0000000000000011 |
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Faculty of Science and Engineering |
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facultyofscienceandengineering |
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Faculty of Science and Engineering |
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facultyofscienceandengineering |
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Faculty of Science and Engineering |
department_str |
School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering |
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description |
Nanowire-based detection strategies provide promising new routes to rapid bioanalysis and detection of disease. These systems have a high degree of potential toward making developments in the diagnosis of disease. The fabrication of active flow microchannels is an essential component of these future noninvasive devices. The present work describes the use of 3-dimensional (3D) printing fabrication techniques for producing a prototype point-of-care system with integrated biochip and active flow microchannels. This microchannel-based device is made from polylactic acid polymer. The reported 3D printed process allowed the fabrication of 400-[mu]m width micochannels, which was integrated with a functionalized silicon nanowire biochip. This technique enabled the production of a combined immunobiosensor with inbuilt flexoprinted contacts. During this research, the biochip was biologically functionalized with antibodies of 8-hydroxydeoxyguanosine (8-OHdG), which is a biomarker linked to several common cancers. The present work describes a fabrication technique for building and testing a 3D printed microchannel-based device that was used to detect 8-OHdG antibodies. |
published_date |
2014-06-30T03:38:21Z |
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1763751705174867968 |
score |
11.028048 |