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A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial / C Foster; C Grimmett; CM May; S Ewings; M Myall; C Hulme; PW Smith; C Powers; L Calman; J Armes; M Breckons; J Corner; D Fenlon; L Batehup; E Lennan; May R; C Morris; A Neylon; E Ream; L Turner; L Yardley; A Richardson

Supportive Care in Cancer, Volume: 24, Issue: 6, Pages: 2445 - 2453

Swansea University Author: Fenlon, Deborah

Abstract

Purpose Cancer-related fatigue (CRF) is a frequent anddistressing symptom experienced after cancer treatment.RESTORE is the first web-based resource designed to enhanceself-efficacy to manage CRF following curative-intenttreatment. The aim of this study is to test the proof of conceptand inform the...

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Published in: Supportive Care in Cancer
ISSN: 0941-4355 1433-7339
Published: 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa32823
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2019-05-08T11:49:11Z</datestamp><bib-version>v2</bib-version><id>32823</id><entry>2017-03-30</entry><title>A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial</title><alternativeTitle></alternativeTitle><author>Deborah Fenlon</author><firstname>Deborah</firstname><surname>Fenlon</surname><active>true</active><ORCID>0000-0001-7347-8919</ORCID><ethesisStudent>false</ethesisStudent><sid>efa6c181fe0a6e5c923b1126ce469186</sid><email>193d2e73f6d44dd4bd37f0225750617c</email><emailaddr>BPvsf/cpSzjDDuDc/DuUoMjwe531u+mO/3IG3xe5jMg=</emailaddr><date>2017-03-30</date><deptcode>HNU</deptcode><abstract>Purpose Cancer-related fatigue (CRF) is a frequent anddistressing symptom experienced after cancer treatment.RESTORE is the first web-based resource designed to enhanceself-efficacy to manage CRF following curative-intenttreatment. The aim of this study is to test the proof of conceptand inform the design of an effectiveness trial.Methods A multi-centre parallel-group two-armed (1:1) exploratoryrandomised controlled trial (RCT) with qualitativeprocess evaluation was employed in the study. Participants(&#x2265;18 years; &#x2264;5 years post treatment with moderate to severefatigue) were recruited and randomly assigned to RESTOREor a leaflet. Feasibility and acceptability were measured byrecruitment, attrition, intervention adherence, completion ofoutcome measures and process evaluation. Change in selfefficacyto manage CRF was also explored. Outcome measureswere completed at baseline (T0), 6 weeks (T1) and12 weeks (T2). Data were analysed using mixed-effects linearregression and directed content analysis.Results One hundred and sixty-three people participated inthe trial and 19 in the process evaluation. The interventionwas feasible (39 % of eligible patients consented) and acceptable(attrition rate 36 %). There was evidence of higher fatigueself-efficacy at T1 in the intervention group vs comparator(mean difference 0.51 [&#x2212;0.08 to 1.11]), though the differencein groups decreased by 12 weeks. Time since diagnosis influencedperceived usefulness of the intervention. Modificationswere suggested.Conclusion Proof of concept was achieved. The RESTOREintervention should be subject to a definitive trial with some adjustments.Provision of an effective supportive resource would empower cancersurvivors to manage CRF after treatment completion.</abstract><type>Journal article</type><journal>Supportive Care in Cancer</journal><volume>24</volume><journalNumber>6</journalNumber><paginationStart>2445</paginationStart><paginationEnd>2453</paginationEnd><publisher></publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0941-4355</issnPrint><issnElectronic>1433-7339</issnElectronic><keywords></keywords><publishedDay>0</publishedDay><publishedMonth>6</publishedMonth><publishedYear>2016</publishedYear><publishedDate>2016-06-01</publishedDate><doi>10.1007/s00520-015-3044-7</doi><url>http://europepmc.org/abstract/med/26643072</url><notes></notes><college>College of Human and Health Sciences</college><department>Nursing</department><CollegeCode>CHHS</CollegeCode><DepartmentCode>HNU</DepartmentCode><institution/><researchGroup>None</researchGroup><supervisor/><sponsorsfunders/><grantnumber/><degreelevel/><degreename/><lastEdited>2019-05-08T11:49:11Z</lastEdited><Created>2017-03-30T14:26:09Z</Created><path><level id="1">College of Human and Health Sciences</level><level id="2">Nursing</level></path><authors><author><firstname>C</firstname><surname>Foster</surname><orcid/><order>1</order></author><author><firstname>C</firstname><surname>Grimmett</surname><orcid/><order>2</order></author><author><firstname>CM</firstname><surname>May</surname><orcid/><order>3</order></author><author><firstname>S</firstname><surname>Ewings</surname><orcid/><order>4</order></author><author><firstname>M</firstname><surname>Myall</surname><orcid/><order>5</order></author><author><firstname>C</firstname><surname>Hulme</surname><orcid/><order>6</order></author><author><firstname>PW</firstname><surname>Smith</surname><orcid/><order>7</order></author><author><firstname>C</firstname><surname>Powers</surname><orcid/><order>8</order></author><author><firstname>L</firstname><surname>Calman</surname><orcid/><order>9</order></author><author><firstname>J</firstname><surname>Armes</surname><orcid/><order>10</order></author><author><firstname>M</firstname><surname>Breckons</surname><orcid/><order>11</order></author><author><firstname>J</firstname><surname>Corner</surname><orcid/><order>12</order></author><author><firstname>D</firstname><surname>Fenlon</surname><orcid/><order>13</order></author><author><firstname>L</firstname><surname>Batehup</surname><orcid/><order>14</order></author><author><firstname>E</firstname><surname>Lennan</surname><orcid/><order>15</order></author><author><firstname>May</firstname><surname>R</surname><orcid/><order>16</order></author><author><firstname>C</firstname><surname>Morris</surname><orcid/><order>17</order></author><author><firstname>A</firstname><surname>Neylon</surname><orcid/><order>18</order></author><author><firstname>E</firstname><surname>Ream</surname><orcid/><order>19</order></author><author><firstname>L</firstname><surname>Turner</surname><orcid/><order>20</order></author><author><firstname>L</firstname><surname>Yardley</surname><orcid/><order>21</order></author><author><firstname>A</firstname><surname>Richardson</surname><orcid/><order>22</order></author></authors><documents><document><filename>0032823-30032017155706.pdf</filename><originalFilename>foster2016.pdf</originalFilename><uploaded>2017-03-30T15:57:06Z</uploaded><type>Output</type><contentLength>493220</contentLength><contentType>application/pdf</contentType><version>AM</version><cronfaStatus>true</cronfaStatus><action>Published to Cronfa</action><actionDate>31/03/2017</actionDate><embargoDate>2017-03-30T00:00:00</embargoDate><documentNotes/><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents></rfc1807>
spelling 2019-05-08T11:49:11Z v2 32823 2017-03-30 A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial Deborah Fenlon Deborah Fenlon true 0000-0001-7347-8919 false efa6c181fe0a6e5c923b1126ce469186 193d2e73f6d44dd4bd37f0225750617c BPvsf/cpSzjDDuDc/DuUoMjwe531u+mO/3IG3xe5jMg= 2017-03-30 HNU Purpose Cancer-related fatigue (CRF) is a frequent anddistressing symptom experienced after cancer treatment.RESTORE is the first web-based resource designed to enhanceself-efficacy to manage CRF following curative-intenttreatment. The aim of this study is to test the proof of conceptand inform the design of an effectiveness trial.Methods A multi-centre parallel-group two-armed (1:1) exploratoryrandomised controlled trial (RCT) with qualitativeprocess evaluation was employed in the study. Participants(≥18 years; ≤5 years post treatment with moderate to severefatigue) were recruited and randomly assigned to RESTOREor a leaflet. Feasibility and acceptability were measured byrecruitment, attrition, intervention adherence, completion ofoutcome measures and process evaluation. Change in selfefficacyto manage CRF was also explored. Outcome measureswere completed at baseline (T0), 6 weeks (T1) and12 weeks (T2). Data were analysed using mixed-effects linearregression and directed content analysis.Results One hundred and sixty-three people participated inthe trial and 19 in the process evaluation. The interventionwas feasible (39 % of eligible patients consented) and acceptable(attrition rate 36 %). There was evidence of higher fatigueself-efficacy at T1 in the intervention group vs comparator(mean difference 0.51 [−0.08 to 1.11]), though the differencein groups decreased by 12 weeks. Time since diagnosis influencedperceived usefulness of the intervention. Modificationswere suggested.Conclusion Proof of concept was achieved. The RESTOREintervention should be subject to a definitive trial with some adjustments.Provision of an effective supportive resource would empower cancersurvivors to manage CRF after treatment completion. Journal article Supportive Care in Cancer 24 6 2445 2453 0941-4355 1433-7339 0 6 2016 2016-06-01 10.1007/s00520-015-3044-7 http://europepmc.org/abstract/med/26643072 College of Human and Health Sciences Nursing CHHS HNU None 2019-05-08T11:49:11Z 2017-03-30T14:26:09Z College of Human and Health Sciences Nursing C Foster 1 C Grimmett 2 CM May 3 S Ewings 4 M Myall 5 C Hulme 6 PW Smith 7 C Powers 8 L Calman 9 J Armes 10 M Breckons 11 J Corner 12 D Fenlon 13 L Batehup 14 E Lennan 15 May R 16 C Morris 17 A Neylon 18 E Ream 19 L Turner 20 L Yardley 21 A Richardson 22 0032823-30032017155706.pdf foster2016.pdf 2017-03-30T15:57:06Z Output 493220 application/pdf AM true Published to Cronfa 31/03/2017 2017-03-30T00:00:00 true eng
title A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial
spellingShingle A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial
Fenlon, Deborah
title_short A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial
title_full A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial
title_fullStr A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial
title_full_unstemmed A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial
title_sort A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial
author_id_str_mv efa6c181fe0a6e5c923b1126ce469186
author_id_fullname_str_mv efa6c181fe0a6e5c923b1126ce469186_***_Fenlon, Deborah
author Fenlon, Deborah
author2 C Foster
C Grimmett
CM May
S Ewings
M Myall
C Hulme
PW Smith
C Powers
L Calman
J Armes
M Breckons
J Corner
D Fenlon
L Batehup
E Lennan
May R
C Morris
A Neylon
E Ream
L Turner
L Yardley
A Richardson
format Journal article
container_title Supportive Care in Cancer
container_volume 24
container_issue 6
container_start_page 2445
publishDate 2016
institution Swansea University
issn 0941-4355
1433-7339
doi_str_mv 10.1007/s00520-015-3044-7
college_str College of Human and Health Sciences
hierarchytype
hierarchy_top_id collegeofhumanandhealthsciences
hierarchy_top_title College of Human and Health Sciences
hierarchy_parent_id collegeofhumanandhealthsciences
hierarchy_parent_title College of Human and Health Sciences
department_str Nursing{{{_:::_}}}College of Human and Health Sciences{{{_:::_}}}Nursing
url http://europepmc.org/abstract/med/26643072
document_store_str 1
active_str 1
description Purpose Cancer-related fatigue (CRF) is a frequent anddistressing symptom experienced after cancer treatment.RESTORE is the first web-based resource designed to enhanceself-efficacy to manage CRF following curative-intenttreatment. The aim of this study is to test the proof of conceptand inform the design of an effectiveness trial.Methods A multi-centre parallel-group two-armed (1:1) exploratoryrandomised controlled trial (RCT) with qualitativeprocess evaluation was employed in the study. Participants(≥18 years; ≤5 years post treatment with moderate to severefatigue) were recruited and randomly assigned to RESTOREor a leaflet. Feasibility and acceptability were measured byrecruitment, attrition, intervention adherence, completion ofoutcome measures and process evaluation. Change in selfefficacyto manage CRF was also explored. Outcome measureswere completed at baseline (T0), 6 weeks (T1) and12 weeks (T2). Data were analysed using mixed-effects linearregression and directed content analysis.Results One hundred and sixty-three people participated inthe trial and 19 in the process evaluation. The interventionwas feasible (39 % of eligible patients consented) and acceptable(attrition rate 36 %). There was evidence of higher fatigueself-efficacy at T1 in the intervention group vs comparator(mean difference 0.51 [−0.08 to 1.11]), though the differencein groups decreased by 12 weeks. Time since diagnosis influencedperceived usefulness of the intervention. Modificationswere suggested.Conclusion Proof of concept was achieved. The RESTOREintervention should be subject to a definitive trial with some adjustments.Provision of an effective supportive resource would empower cancersurvivors to manage CRF after treatment completion.
published_date 2016-06-01T04:46:04Z
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