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A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial

C Foster, C Grimmett, CM May, S Ewings, M Myall, C Hulme, PW Smith, C Powers, L Calman, J Armes, M Breckons, J Corner, D Fenlon, L Batehup, E Lennan, May R, C Morris, A Neylon, E Ream, L Turner, L Yardley, A Richardson, Deborah Fenlon

Supportive Care in Cancer, Volume: 24, Issue: 6, Pages: 2445 - 2453

Swansea University Author: Deborah Fenlon

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DOI (Published version): 10.1007/s00520-015-3044-7

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Purpose Cancer-related fatigue (CRF) is a frequent anddistressing symptom experienced after cancer treatment.RESTORE is the first web-based resource designed to enhanceself-efficacy to manage CRF following curative-intenttreatment. The aim of this study is to test the proof of conceptand inform the...

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Published in: Supportive Care in Cancer
ISSN: 0941-4355 1433-7339
Published: 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa32823
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2020-10-06T13:43:54.0532314</datestamp><bib-version>v2</bib-version><id>32823</id><entry>2017-03-30</entry><title>A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial</title><swanseaauthors><author><sid>efa6c181fe0a6e5c923b1126ce469186</sid><firstname>Deborah</firstname><surname>Fenlon</surname><name>Deborah Fenlon</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2017-03-30</date><deptcode>FGMHL</deptcode><abstract>Purpose Cancer-related fatigue (CRF) is a frequent anddistressing symptom experienced after cancer treatment.RESTORE is the first web-based resource designed to enhanceself-efficacy to manage CRF following curative-intenttreatment. The aim of this study is to test the proof of conceptand inform the design of an effectiveness trial.Methods A multi-centre parallel-group two-armed (1:1) exploratoryrandomised controlled trial (RCT) with qualitativeprocess evaluation was employed in the study. Participants(&#x2265;18 years; &#x2264;5 years post treatment with moderate to severefatigue) were recruited and randomly assigned to RESTOREor a leaflet. Feasibility and acceptability were measured byrecruitment, attrition, intervention adherence, completion ofoutcome measures and process evaluation. Change in selfefficacyto manage CRF was also explored. Outcome measureswere completed at baseline (T0), 6 weeks (T1) and12 weeks (T2). Data were analysed using mixed-effects linearregression and directed content analysis.Results One hundred and sixty-three people participated inthe trial and 19 in the process evaluation. The interventionwas feasible (39 % of eligible patients consented) and acceptable(attrition rate 36 %). There was evidence of higher fatigueself-efficacy at T1 in the intervention group vs comparator(mean difference 0.51 [&#x2212;0.08 to 1.11]), though the differencein groups decreased by 12 weeks. Time since diagnosis influencedperceived usefulness of the intervention. Modificationswere suggested.Conclusion Proof of concept was achieved. The RESTOREintervention should be subject to a definitive trial with some adjustments.Provision of an effective supportive resource would empower cancersurvivors to manage CRF after treatment completion.</abstract><type>Journal Article</type><journal>Supportive Care in Cancer</journal><volume>24</volume><journalNumber>6</journalNumber><paginationStart>2445</paginationStart><paginationEnd>2453</paginationEnd><publisher/><issnPrint>0941-4355</issnPrint><issnElectronic>1433-7339</issnElectronic><keywords/><publishedDay>30</publishedDay><publishedMonth>6</publishedMonth><publishedYear>2016</publishedYear><publishedDate>2016-06-30</publishedDate><doi>10.1007/s00520-015-3044-7</doi><url>http://europepmc.org/abstract/med/26643072</url><notes/><college>COLLEGE NANME</college><department>Medicine, Health and Life Science - Faculty</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>FGMHL</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2020-10-06T13:43:54.0532314</lastEdited><Created>2017-03-30T14:26:09.8773701</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">School of Health and Social Care - Nursing</level></path><authors><author><firstname>C</firstname><surname>Foster</surname><order>1</order></author><author><firstname>C</firstname><surname>Grimmett</surname><order>2</order></author><author><firstname>CM</firstname><surname>May</surname><order>3</order></author><author><firstname>S</firstname><surname>Ewings</surname><order>4</order></author><author><firstname>M</firstname><surname>Myall</surname><order>5</order></author><author><firstname>C</firstname><surname>Hulme</surname><order>6</order></author><author><firstname>PW</firstname><surname>Smith</surname><order>7</order></author><author><firstname>C</firstname><surname>Powers</surname><order>8</order></author><author><firstname>L</firstname><surname>Calman</surname><order>9</order></author><author><firstname>J</firstname><surname>Armes</surname><order>10</order></author><author><firstname>M</firstname><surname>Breckons</surname><order>11</order></author><author><firstname>J</firstname><surname>Corner</surname><order>12</order></author><author><firstname>D</firstname><surname>Fenlon</surname><order>13</order></author><author><firstname>L</firstname><surname>Batehup</surname><order>14</order></author><author><firstname>E</firstname><surname>Lennan</surname><order>15</order></author><author><firstname>May</firstname><surname>R</surname><order>16</order></author><author><firstname>C</firstname><surname>Morris</surname><order>17</order></author><author><firstname>A</firstname><surname>Neylon</surname><order>18</order></author><author><firstname>E</firstname><surname>Ream</surname><order>19</order></author><author><firstname>L</firstname><surname>Turner</surname><order>20</order></author><author><firstname>L</firstname><surname>Yardley</surname><order>21</order></author><author><firstname>A</firstname><surname>Richardson</surname><order>22</order></author><author><firstname>Deborah</firstname><surname>Fenlon</surname><order>23</order></author></authors><documents><document><filename>0032823-30032017155706.pdf</filename><originalFilename>foster2016.pdf</originalFilename><uploaded>2017-03-30T15:57:06.4270000</uploaded><type>Output</type><contentLength>493220</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2017-03-30T00:00:00.0000000</embargoDate><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2020-10-06T13:43:54.0532314 v2 32823 2017-03-30 A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial efa6c181fe0a6e5c923b1126ce469186 Deborah Fenlon Deborah Fenlon true false 2017-03-30 FGMHL Purpose Cancer-related fatigue (CRF) is a frequent anddistressing symptom experienced after cancer treatment.RESTORE is the first web-based resource designed to enhanceself-efficacy to manage CRF following curative-intenttreatment. The aim of this study is to test the proof of conceptand inform the design of an effectiveness trial.Methods A multi-centre parallel-group two-armed (1:1) exploratoryrandomised controlled trial (RCT) with qualitativeprocess evaluation was employed in the study. Participants(≥18 years; ≤5 years post treatment with moderate to severefatigue) were recruited and randomly assigned to RESTOREor a leaflet. Feasibility and acceptability were measured byrecruitment, attrition, intervention adherence, completion ofoutcome measures and process evaluation. Change in selfefficacyto manage CRF was also explored. Outcome measureswere completed at baseline (T0), 6 weeks (T1) and12 weeks (T2). Data were analysed using mixed-effects linearregression and directed content analysis.Results One hundred and sixty-three people participated inthe trial and 19 in the process evaluation. The interventionwas feasible (39 % of eligible patients consented) and acceptable(attrition rate 36 %). There was evidence of higher fatigueself-efficacy at T1 in the intervention group vs comparator(mean difference 0.51 [−0.08 to 1.11]), though the differencein groups decreased by 12 weeks. Time since diagnosis influencedperceived usefulness of the intervention. Modificationswere suggested.Conclusion Proof of concept was achieved. The RESTOREintervention should be subject to a definitive trial with some adjustments.Provision of an effective supportive resource would empower cancersurvivors to manage CRF after treatment completion. Journal Article Supportive Care in Cancer 24 6 2445 2453 0941-4355 1433-7339 30 6 2016 2016-06-30 10.1007/s00520-015-3044-7 http://europepmc.org/abstract/med/26643072 COLLEGE NANME Medicine, Health and Life Science - Faculty COLLEGE CODE FGMHL Swansea University 2020-10-06T13:43:54.0532314 2017-03-30T14:26:09.8773701 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Nursing C Foster 1 C Grimmett 2 CM May 3 S Ewings 4 M Myall 5 C Hulme 6 PW Smith 7 C Powers 8 L Calman 9 J Armes 10 M Breckons 11 J Corner 12 D Fenlon 13 L Batehup 14 E Lennan 15 May R 16 C Morris 17 A Neylon 18 E Ream 19 L Turner 20 L Yardley 21 A Richardson 22 Deborah Fenlon 23 0032823-30032017155706.pdf foster2016.pdf 2017-03-30T15:57:06.4270000 Output 493220 application/pdf Accepted Manuscript true 2017-03-30T00:00:00.0000000 true eng
title A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial
spellingShingle A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial
Deborah Fenlon
title_short A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial
title_full A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial
title_fullStr A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial
title_full_unstemmed A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial
title_sort A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial
author_id_str_mv efa6c181fe0a6e5c923b1126ce469186
author_id_fullname_str_mv efa6c181fe0a6e5c923b1126ce469186_***_Deborah Fenlon
author Deborah Fenlon
author2 C Foster
C Grimmett
CM May
S Ewings
M Myall
C Hulme
PW Smith
C Powers
L Calman
J Armes
M Breckons
J Corner
D Fenlon
L Batehup
E Lennan
May R
C Morris
A Neylon
E Ream
L Turner
L Yardley
A Richardson
Deborah Fenlon
format Journal article
container_title Supportive Care in Cancer
container_volume 24
container_issue 6
container_start_page 2445
publishDate 2016
institution Swansea University
issn 0941-4355
1433-7339
doi_str_mv 10.1007/s00520-015-3044-7
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Nursing{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Nursing
url http://europepmc.org/abstract/med/26643072
document_store_str 1
active_str 0
description Purpose Cancer-related fatigue (CRF) is a frequent anddistressing symptom experienced after cancer treatment.RESTORE is the first web-based resource designed to enhanceself-efficacy to manage CRF following curative-intenttreatment. The aim of this study is to test the proof of conceptand inform the design of an effectiveness trial.Methods A multi-centre parallel-group two-armed (1:1) exploratoryrandomised controlled trial (RCT) with qualitativeprocess evaluation was employed in the study. Participants(≥18 years; ≤5 years post treatment with moderate to severefatigue) were recruited and randomly assigned to RESTOREor a leaflet. Feasibility and acceptability were measured byrecruitment, attrition, intervention adherence, completion ofoutcome measures and process evaluation. Change in selfefficacyto manage CRF was also explored. Outcome measureswere completed at baseline (T0), 6 weeks (T1) and12 weeks (T2). Data were analysed using mixed-effects linearregression and directed content analysis.Results One hundred and sixty-three people participated inthe trial and 19 in the process evaluation. The interventionwas feasible (39 % of eligible patients consented) and acceptable(attrition rate 36 %). There was evidence of higher fatigueself-efficacy at T1 in the intervention group vs comparator(mean difference 0.51 [−0.08 to 1.11]), though the differencein groups decreased by 12 weeks. Time since diagnosis influencedperceived usefulness of the intervention. Modificationswere suggested.Conclusion Proof of concept was achieved. The RESTOREintervention should be subject to a definitive trial with some adjustments.Provision of an effective supportive resource would empower cancersurvivors to manage CRF after treatment completion.
published_date 2016-06-30T03:40:21Z
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score 11.036706

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