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Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring / Sanjiv Sharma; Zhenyi Huang; Michelle Rogers; Martyn Boutelle; Anthony E. G. Cass

Analytical and Bioanalytical Chemistry, Volume: 408, Issue: 29, Pages: 8427 - 8435

Swansea University Author: Sanjiv, Sharma

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Abstract

We describe here a minimally invasive glucose biosensor based on a microneedle array electrode fabricated from an epoxy-based negative photoresist (SU8 50) and designed for continuous measurement in the dermal compartment with minimal pain. These minimally invasive, continuous monitoring sensor devi...

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Published in: Analytical and Bioanalytical Chemistry
ISSN: 1618-2642 1618-2650
Published: Springer Nature 2016
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa36255
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Abstract: We describe here a minimally invasive glucose biosensor based on a microneedle array electrode fabricated from an epoxy-based negative photoresist (SU8 50) and designed for continuous measurement in the dermal compartment with minimal pain. These minimally invasive, continuous monitoring sensor devices (MICoMS) were produced by casting the structures in SU8 50, crosslinking and then metallising them with platinum or silver to obtain the working and reference electrodes, respectively. The metallised microneedle array electrodes were subsequently functionalised by entrapping glucose oxidase in electropolymerised polyphenol (PP) film. Sensor performance in vitro showed that glucose concentrations down to 0.5 mM could be measured with a response times (T90) of 15 s. The effect of sterilisation by Co60 irradiation was evaluated. In preparation for further clinical studies, these sensors were tested in vivo in a healthy volunteer for a period of 3–6 h. The sensor currents were compared against point measurements obtained with a commercial capillary blood glucometer. The epoxy MICoMS devices showed currents values that could be correlated with these.
Keywords: Microneedles, Electrochemical sensor, Continuous glucose monitoring (CGM)
College: College of Engineering
Issue: 29
Start Page: 8427
End Page: 8435