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Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring

Sanjiv Sharma Orcid Logo, Zhenyi Huang, Michelle Rogers, Martyn Boutelle, Anthony E. G. Cass

Analytical and Bioanalytical Chemistry, Volume: 408, Issue: 29, Pages: 8427 - 8435

Swansea University Author: Sanjiv Sharma Orcid Logo

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DOI (Published version): 10.1007/s00216-016-9961-6

Abstract

We describe here a minimally invasive glucose biosensor based on a microneedle array electrode fabricated from an epoxy-based negative photoresist (SU8 50) and designed for continuous measurement in the dermal compartment with minimal pain. These minimally invasive, continuous monitoring sensor devi...

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Published in: Analytical and Bioanalytical Chemistry
ISSN: 1618-2642 1618-2650
Published: Springer Nature 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa36255
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spelling 2020-07-14T12:12:38.1884733 v2 36255 2017-10-25 Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring b6b7506358522f607b171ec9c94757b7 0000-0003-3828-737X Sanjiv Sharma Sanjiv Sharma true false 2017-10-25 MEDE We describe here a minimally invasive glucose biosensor based on a microneedle array electrode fabricated from an epoxy-based negative photoresist (SU8 50) and designed for continuous measurement in the dermal compartment with minimal pain. These minimally invasive, continuous monitoring sensor devices (MICoMS) were produced by casting the structures in SU8 50, crosslinking and then metallising them with platinum or silver to obtain the working and reference electrodes, respectively. The metallised microneedle array electrodes were subsequently functionalised by entrapping glucose oxidase in electropolymerised polyphenol (PP) film. Sensor performance in vitro showed that glucose concentrations down to 0.5 mM could be measured with a response times (T90) of 15 s. The effect of sterilisation by Co60 irradiation was evaluated. In preparation for further clinical studies, these sensors were tested in vivo in a healthy volunteer for a period of 3–6 h. The sensor currents were compared against point measurements obtained with a commercial capillary blood glucometer. The epoxy MICoMS devices showed currents values that could be correlated with these. Journal Article Analytical and Bioanalytical Chemistry 408 29 8427 8435 Springer Nature 1618-2642 1618-2650 Microneedles, Electrochemical sensor, Continuous glucose monitoring (CGM) 15 11 2016 2016-11-15 10.1007/s00216-016-9961-6 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2020-07-14T12:12:38.1884733 2017-10-25T14:06:22.6321492 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Sanjiv Sharma 0000-0003-3828-737X 1 Zhenyi Huang 2 Michelle Rogers 3 Martyn Boutelle 4 Anthony E. G. Cass 5 0036255-26102017090251.pdf sharma2017(2).pdf 2017-10-26T09:02:51.1070000 Output 1420967 application/pdf Version of Record true 2017-10-26T00:00:00.0000000 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring
spellingShingle Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring
Sanjiv Sharma
title_short Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring
title_full Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring
title_fullStr Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring
title_full_unstemmed Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring
title_sort Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring
author_id_str_mv b6b7506358522f607b171ec9c94757b7
author_id_fullname_str_mv b6b7506358522f607b171ec9c94757b7_***_Sanjiv Sharma
author Sanjiv Sharma
author2 Sanjiv Sharma
Zhenyi Huang
Michelle Rogers
Martyn Boutelle
Anthony E. G. Cass
format Journal article
container_title Analytical and Bioanalytical Chemistry
container_volume 408
container_issue 29
container_start_page 8427
publishDate 2016
institution Swansea University
issn 1618-2642
1618-2650
doi_str_mv 10.1007/s00216-016-9961-6
publisher Springer Nature
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
active_str 0
description We describe here a minimally invasive glucose biosensor based on a microneedle array electrode fabricated from an epoxy-based negative photoresist (SU8 50) and designed for continuous measurement in the dermal compartment with minimal pain. These minimally invasive, continuous monitoring sensor devices (MICoMS) were produced by casting the structures in SU8 50, crosslinking and then metallising them with platinum or silver to obtain the working and reference electrodes, respectively. The metallised microneedle array electrodes were subsequently functionalised by entrapping glucose oxidase in electropolymerised polyphenol (PP) film. Sensor performance in vitro showed that glucose concentrations down to 0.5 mM could be measured with a response times (T90) of 15 s. The effect of sterilisation by Co60 irradiation was evaluated. In preparation for further clinical studies, these sensors were tested in vivo in a healthy volunteer for a period of 3–6 h. The sensor currents were compared against point measurements obtained with a commercial capillary blood glucometer. The epoxy MICoMS devices showed currents values that could be correlated with these.
published_date 2016-11-15T03:45:16Z
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score 11.016235

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