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Conference Paper/Proceeding/Abstract 1156 views 168 downloads

Minimally Invasive Microneedle Array Electrodes Employing Direct Electron Transfer Type Glucose Dehydrogenase for the Development of Continuous Glucose Monitoring Sensors

Sanjiv Sharma Orcid Logo, Eri Takagi, Tony Cass, Wakako Tsugawa, Koji Sode

Procedia Technology, Volume: 27, Pages: 208 - 209

Swansea University Author: Sanjiv Sharma Orcid Logo

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DOI (Published version): 10.1016/j.protcy.2017.04.087

Abstract

Closed loop systems hinge on the accuracy and precision of the continuous glucose monitoring sensors. Most of the commercially available continuous glucose monitoring sensors is implanted subcutaneously for a period of 7-14 days. The subsequent biofouling effects have implications on the performance...

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Published in: Procedia Technology
ISSN: 2212-0173
Published: 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa36438
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first_indexed 2017-11-01T19:54:03Z
last_indexed 2018-02-09T05:28:43Z
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spelling 2017-11-09T14:15:59.7454209 v2 36438 2017-11-01 Minimally Invasive Microneedle Array Electrodes Employing Direct Electron Transfer Type Glucose Dehydrogenase for the Development of Continuous Glucose Monitoring Sensors b6b7506358522f607b171ec9c94757b7 0000-0003-3828-737X Sanjiv Sharma Sanjiv Sharma true false 2017-11-01 MEDE Closed loop systems hinge on the accuracy and precision of the continuous glucose monitoring sensors. Most of the commercially available continuous glucose monitoring sensors is implanted subcutaneously for a period of 7-14 days. The subsequent biofouling effects have implications on the performance of the sensors over time especially at low glucose concentrations. In addition, the commercially available sensors are sensitive to the presence of interfering species such as acetaminophen in the skin compartment. We report here on the marriage of minimally invasive, continuous glucose sensors and a direct electron transfer type glucose dehydrogenase enzymatic system. Whilst the microneedles here are designed to sit in the dermal interstitial fluid over a 24-48 hour period to minimize the biofouling effect, the direct electron transfer enzyme allows operation of the electrochemical sensor at lower potentials to minimize the effect of interference. The microneedle structure design also enables the use of compensation electrodes for background subtraction to further nullify the effects of interference. Conference Paper/Proceeding/Abstract Procedia Technology 27 208 209 2212-0173 continuous glucose monitoring, minimally invasive sensors, direct electron transfer, microneedles 1 1 2017 2017-01-01 10.1016/j.protcy.2017.04.087 http://www.sciencedirect.com/science/article/pii/S2212017317300889 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2017-11-09T14:15:59.7454209 2017-11-01T16:25:02.2145214 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Sanjiv Sharma 0000-0003-3828-737X 1 Eri Takagi 2 Tony Cass 3 Wakako Tsugawa 4 Koji Sode 5 0036438-09112017141011.pdf sharma2017(3).pdf 2017-11-09T14:10:11.3000000 Output 385999 application/pdf Version of Record true 2017-11-09T00:00:00.0000000 false eng
title Minimally Invasive Microneedle Array Electrodes Employing Direct Electron Transfer Type Glucose Dehydrogenase for the Development of Continuous Glucose Monitoring Sensors
spellingShingle Minimally Invasive Microneedle Array Electrodes Employing Direct Electron Transfer Type Glucose Dehydrogenase for the Development of Continuous Glucose Monitoring Sensors
Sanjiv Sharma
title_short Minimally Invasive Microneedle Array Electrodes Employing Direct Electron Transfer Type Glucose Dehydrogenase for the Development of Continuous Glucose Monitoring Sensors
title_full Minimally Invasive Microneedle Array Electrodes Employing Direct Electron Transfer Type Glucose Dehydrogenase for the Development of Continuous Glucose Monitoring Sensors
title_fullStr Minimally Invasive Microneedle Array Electrodes Employing Direct Electron Transfer Type Glucose Dehydrogenase for the Development of Continuous Glucose Monitoring Sensors
title_full_unstemmed Minimally Invasive Microneedle Array Electrodes Employing Direct Electron Transfer Type Glucose Dehydrogenase for the Development of Continuous Glucose Monitoring Sensors
title_sort Minimally Invasive Microneedle Array Electrodes Employing Direct Electron Transfer Type Glucose Dehydrogenase for the Development of Continuous Glucose Monitoring Sensors
author_id_str_mv b6b7506358522f607b171ec9c94757b7
author_id_fullname_str_mv b6b7506358522f607b171ec9c94757b7_***_Sanjiv Sharma
author Sanjiv Sharma
author2 Sanjiv Sharma
Eri Takagi
Tony Cass
Wakako Tsugawa
Koji Sode
format Conference Paper/Proceeding/Abstract
container_title Procedia Technology
container_volume 27
container_start_page 208
publishDate 2017
institution Swansea University
issn 2212-0173
doi_str_mv 10.1016/j.protcy.2017.04.087
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
url http://www.sciencedirect.com/science/article/pii/S2212017317300889
document_store_str 1
active_str 0
description Closed loop systems hinge on the accuracy and precision of the continuous glucose monitoring sensors. Most of the commercially available continuous glucose monitoring sensors is implanted subcutaneously for a period of 7-14 days. The subsequent biofouling effects have implications on the performance of the sensors over time especially at low glucose concentrations. In addition, the commercially available sensors are sensitive to the presence of interfering species such as acetaminophen in the skin compartment. We report here on the marriage of minimally invasive, continuous glucose sensors and a direct electron transfer type glucose dehydrogenase enzymatic system. Whilst the microneedles here are designed to sit in the dermal interstitial fluid over a 24-48 hour period to minimize the biofouling effect, the direct electron transfer enzyme allows operation of the electrochemical sensor at lower potentials to minimize the effect of interference. The microneedle structure design also enables the use of compensation electrodes for background subtraction to further nullify the effects of interference.
published_date 2017-01-01T03:45:34Z
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score 11.012678

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