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Microstructural Consequences of Blast Lung Injury Characterized with Digital Volume Correlation

Hari Arora Orcid Logo, Alex Nila, Kalpani Vitharana, Joseph M. Sherwood, Thuy-Tien N. Nguyen, Angelo Karunaratne, Idris K. Mohammed, Andrew J. Bodey, Peter J. Hellyer, Darryl R. Overby, Robert C. Schroter, Dave Hollis

Frontiers in Materials, Volume: 4

Swansea University Author: Hari Arora Orcid Logo

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Abstract

This study focuses on microstructural changes that occur within the mammalian lung when subject to blast and how these changes influence strain distributions within the tissue. Shock tube experiments were performed to generate the blast injured specimens (cadaveric Sprague-Dawley rats). Blast overpr...

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Published in: Frontiers in Materials
ISSN: 2296-8016
Published: 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa37049
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spelling 2020-07-14T11:27:21.2271948 v2 37049 2017-11-24 Microstructural Consequences of Blast Lung Injury Characterized with Digital Volume Correlation ed7371c768e9746008a6807f9f7a1555 0000-0002-9790-0907 Hari Arora Hari Arora true false 2017-11-24 MEDE This study focuses on microstructural changes that occur within the mammalian lung when subject to blast and how these changes influence strain distributions within the tissue. Shock tube experiments were performed to generate the blast injured specimens (cadaveric Sprague-Dawley rats). Blast overpressures of 100 and 180 kPa were studied. Synchrotron tomography imaging was used to capture volumetric image data of lungs. Specimens were ventilated using a custom-built system to study multiple inflation pressures during each tomography scan. These data enabled the first digital volume correlation (DVC) measurements in lung tissue to be performed. Quantitative analysis was performed to describe the damaged architecture of the lung. No clear changes in the microstructure of the tissue morphology were observed due to controlled low- to moderate-level blast exposure. However, significant focal sites of injury were observed using DVC, which allowed the detection of bias and concentration in the patterns of strain level. Morphological analysis corroborated the findings, illustrating that the focal damage caused by a blast can give rise to diffuse influence across the tissue. It is important to characterize the non-instantly fatal doses of blast, given the transient nature of blast lung in the clinical setting. This research has highlighted the need for better understanding of focal injury and its zone of influence (alveolar interdependency and neighboring tissue burden as a result of focal injury). DVC techniques show great promise as a tool to advance this endeavor, providing a new perspective on lung mechanics after blast. Journal Article Frontiers in Materials 4 2296-8016 Digital volume correlation, Blast lung injury, Synchrotron tomography, Lung microstructure, shock tube, Lung biomechanics 13 12 2017 2017-12-13 10.3389/fmats.2017.00041 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2020-07-14T11:27:21.2271948 2017-11-24T12:47:30.9917847 Hari Arora 0000-0002-9790-0907 1 Alex Nila 2 Kalpani Vitharana 3 Joseph M. Sherwood 4 Thuy-Tien N. Nguyen 5 Angelo Karunaratne 6 Idris K. Mohammed 7 Andrew J. Bodey 8 Peter J. Hellyer 9 Darryl R. Overby 10 Robert C. Schroter 11 Dave Hollis 12 0037049-13122017112712.pdf arora2017(2).pdf 2017-12-13T11:27:12.9870000 Output 3640286 application/pdf Version of Record true 2017-12-13T00:00:00.0000000 This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) true eng https://creativecommons.org/licenses/by/4.0/
title Microstructural Consequences of Blast Lung Injury Characterized with Digital Volume Correlation
spellingShingle Microstructural Consequences of Blast Lung Injury Characterized with Digital Volume Correlation
Hari Arora
title_short Microstructural Consequences of Blast Lung Injury Characterized with Digital Volume Correlation
title_full Microstructural Consequences of Blast Lung Injury Characterized with Digital Volume Correlation
title_fullStr Microstructural Consequences of Blast Lung Injury Characterized with Digital Volume Correlation
title_full_unstemmed Microstructural Consequences of Blast Lung Injury Characterized with Digital Volume Correlation
title_sort Microstructural Consequences of Blast Lung Injury Characterized with Digital Volume Correlation
author_id_str_mv ed7371c768e9746008a6807f9f7a1555
author_id_fullname_str_mv ed7371c768e9746008a6807f9f7a1555_***_Hari Arora
author Hari Arora
author2 Hari Arora
Alex Nila
Kalpani Vitharana
Joseph M. Sherwood
Thuy-Tien N. Nguyen
Angelo Karunaratne
Idris K. Mohammed
Andrew J. Bodey
Peter J. Hellyer
Darryl R. Overby
Robert C. Schroter
Dave Hollis
format Journal article
container_title Frontiers in Materials
container_volume 4
publishDate 2017
institution Swansea University
issn 2296-8016
doi_str_mv 10.3389/fmats.2017.00041
document_store_str 1
active_str 0
description This study focuses on microstructural changes that occur within the mammalian lung when subject to blast and how these changes influence strain distributions within the tissue. Shock tube experiments were performed to generate the blast injured specimens (cadaveric Sprague-Dawley rats). Blast overpressures of 100 and 180 kPa were studied. Synchrotron tomography imaging was used to capture volumetric image data of lungs. Specimens were ventilated using a custom-built system to study multiple inflation pressures during each tomography scan. These data enabled the first digital volume correlation (DVC) measurements in lung tissue to be performed. Quantitative analysis was performed to describe the damaged architecture of the lung. No clear changes in the microstructure of the tissue morphology were observed due to controlled low- to moderate-level blast exposure. However, significant focal sites of injury were observed using DVC, which allowed the detection of bias and concentration in the patterns of strain level. Morphological analysis corroborated the findings, illustrating that the focal damage caused by a blast can give rise to diffuse influence across the tissue. It is important to characterize the non-instantly fatal doses of blast, given the transient nature of blast lung in the clinical setting. This research has highlighted the need for better understanding of focal injury and its zone of influence (alveolar interdependency and neighboring tissue burden as a result of focal injury). DVC techniques show great promise as a tool to advance this endeavor, providing a new perspective on lung mechanics after blast.
published_date 2017-12-13T03:50:24Z
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